Zusammenfassung
In den letzten Jahren ist die Anzahl von fMRT-Studien, die die neuralen Effekte von Psychopharmaka untersuchen, enorm gestiegen. Das Kapitel erklärt Sinn und Nutzen solcher pharmakologischen fMRT-Studien und gibt einen Überblick über die wichtigsten Arbeiten.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
10.8 Literatur
Abel KM, Allin MP, Kucharska-Pietura K, David A, Andrew C, Williams S, Brammer MJ, Phillips ML (2003) Ketamine alters neural processing of facial emotion recognition in healthy men: an fMRI study. Neuroreport 14:387–391
Anderson IM, Clark L, Elliott R, Kulkarni B, Williams SR, Deakin JF (2002) 5-HT(2C) receptor activation by m-chlorophenylpiperazine detected in humans with fMRI. Neuroreport 13:1547–1551
Bentley P, Vuilleumier P, Thiel CM, Driver J, Dolan RJ (2003) Cholinergic enhancement modulates neural correlates of selective attention and emotional processing. NeuroImage 20:58–70
Bentley P, Husain M, Dolan RJ (2004) Effects of cholinergic enhancement on visual stimulation, spatial attention, and spatial working memory. Neuron 41:969–982
Bloom AS, Hoffmann RG, Fuller SA, Pankiewicz J, Harsch HH, Stein EA (1999) Determination of drug-induced changes in functional MRI signal using a pharmacokinetic model. Hum Brain Mapp 8:235–244
Bullmore E, Suckling J, Zelaya F, Long C, Honey G, Reed L, Routledge C, Ng V, Fletcher P, Brown J, Williams SC (2003) Practice and difficulty evoke anatomically and pharmacologically dissociable brain activation dynamics. Cereb Cortex 13:144–154
Coull JT, Nobre AC, Frith CD (2001) The noradrenergic alpha2 agonist clonidine modulates behavioural and neuroanatomical correlates of human attentional orienting and alerting. Cereb Cortex 11:73–84
Coull JT, Jones M, Egan T, Frith CD, Maze M (2004) Noradrenergic a2 attentional effects vary with arousal level: modulation of the thalamic pulvinar in healthy humans. Neuroimage 22:315–322
Furey ML, Pietrini P, Haxby JV (2000) Cholinergic enhancement and increased selectivity of perceptual processing during working memory. Science 290:2315–2319
Hariri AR, Mattay VS, Tessitore A, Fera F, Smith WG, Weinberger DR (2002) Dextroamphetamine modulates the response of the human amygdala. Neuropsychopharmacol 27:1036–1040
Honey G, Bullmore E (2004) Human pharmacological MRI. Trends Pharmacol Sci 25:366–374
Honey RA, Honey GD, O’Loughlin C, Sharar SR, Kumaran D, Bullmore ET, Menon DK, Donovan T, Lupson VC, Bisbrown-Chippendale R, Fletcher PC (2004) Acute ketamine administration alters the brain responses to executive demands in a verbal working memory task: an FMRI study. Neuropsychopharmacol 29:1203–1214
Kimberg DY, Aguirre GK, Lease J, D’Esposito M (2001) Cortical effects of bromocriptine, a D-2 dopamine receptor agonist, in human subjects, revealed by fMRI. Hum Brain Mapp 12:246–257
Lawrence NS, Ross TJ, Stein EA (2002) Cognitive mechanisms of nicotine on visual attention. Neuron 36:539–548
Leslie RA, James MF (2000) Pharmacological magnetic resonance imaging: a new application for functional MRI. Trends Pharmacol Sci 21:314–318
Loubinoux I, Pariente J, Boulanouar K, Carel C, Manelfe C, Rascol O, Celsis P, Chollet F (2002) A single dose of the serotonin neurotransmission agonist paroxetine enhances motor output: double-blind, plazebo-controlled, fMRI study in healthy subjects. NeuroImage 15:26–36
Mattay VS, Callicott JH, Bertolino A, Heaton I, Frank JA, Coppola R, Berman KF, Goldberg TE, Weinberger DR (2000) Effects of dextroamphetamine on cognitive performance and cortical activation. NeuroImage 12:268–275
Mehta MA, Owen AM, Sahakian BJ, Mavaddat N, Pickard JD, Robbins TW (2000) Methylphenidate enhances working memory by modulating discrete frontal and parietal lobe regions in the human brain. J Neurosci 20:RC65
Northoff G, Witzel T, Richter A, Gessner M, Schlagenhauf F, Fell J, Baumgart F, Kaulisch T, Tempelmann C, Heinzel A, Kotter R, Hagner T, Bargel B, Hinrichs H, Bogerts B, Scheich H, Heinze HJ (2002) GABA-ergic modulation of prefrontal spatio-temporal activation pattern during emotional processing: a combined fMRI/MEG study with Plazebo and lorazepam. J Cogn Neurosci 14:348–370
Pariente J, Loubinoux I, Carel C, Albucher JF, Leger A, Manelfe C, Rascol O, Chollet F (2001) Fluoxetine modulates motor performance and cerebral activation of patients recovering from stroke. Ann Neurol 50:718–729
Sperling R, Greve D, Dale A, Killiany R, Holmes J, Rosas HD, Cocchiarella A, Firth P, Rosen B, Lake S, Lange N, Routledge C, Albert M (2002) Functional MRI detection of pharmacologically induced memory impairment. Proc Natl Acad Sci USA 99:455–460
Stein EA, Pankiewicz J, Harsch HH, Cho JK, Fuller SA, Hoffmann RG, Hawkins M, Rao SM, Bandettini PA, Bloom AS (1998) Nicotine-induced limbic cortical activation in the human brain: a functional MRI study. Am J Psychiatry 155:1009–1015
Stephenson CM, Suckling J, Dirckx SG, Ooi C, McKenna PJ, Bisbrown-Chippendale R, Kerwin RW, Pickard JD, Bullmore ET (2003) GABAergic inhibitory mechanisms for repetition-adaptivity in large-scale brain systems. NeuroImage 19:1578–1588
Strange BA, Dolan RJ (2004) Beta-adrenergic modulation of emotional memory-evoked human amygdala and hippocampal responses. Proc Natl Acad Sci USA 101:11454–11458
Thiel CM, Henson RA, Morris JS, Friston KJ, Dolan RJ (2001) Pharmacological modulation of behavioural and neuronal correlates of repetition priming. J Neurosci 21:6846–6852
Thiel CM, Bentley P, Dolan RJ (2002a) Effects of cholinergic enhancement on conditioning-related responses in human auditory cortex. Eur J Neurosci 16:2199–2206
Thiel CM, Friston KJ, Dolan RJ (2002b) Cholinergic modulation of experience-dependent plasticity in human auditory cortex. Neuron 35:567–574
Thiel CM, Henson RN, Dolan RJ (2002c) Scopolamine but not lorazepam modulates face repetition priming: a psychopharmacological fMRI study. Neuropsychopharmacol 27:282–292
Thiel CM, Zilles K, Fink GR (2005) Nicotine modulates reorienting of visuospatial attention and neural activity in parietal cortex. Neuropsychopharmacol 30:810–820
Wise RG, Rogers R, Painter D, Bantick S, Ploghaus A, Williams P, Rapeport G, Tracey I (2002) Combining fMRI with a pharmacokinetic model to determine which brain areas activated by painful stimulation are specifically modulated by remifentanil. NeuroImage 16:999–1014
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2007 Springer Medizin Verlag Heidelberg
About this chapter
Cite this chapter
Thiel, C., Fink, G.R. (2007). Neuropharmakologische funktionelle Bildgebung. In: Schneider, F., Fink, G.R. (eds) Funktionelle MRT in Psychiatrie und Neurologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-68558-6_11
Download citation
DOI: https://doi.org/10.1007/978-3-540-68558-6_11
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-20474-9
Online ISBN: 978-3-540-68558-6
eBook Packages: Medicine (German Language)