Modification of Nano-sized Materials for Drug Delivery

Xu, Tao; Nichols, Heather L.; Zhang, Ning; Wen, Xuejun

doi:10.1007/978-3-540-49661-8_15

Modification of Nano-sized Materials for Drug Delivery

Tao Xu^4,5,
Heather L. Nichols⁴,
Ning Zhang^4,6 &
…
Xuejun Wen^4,6,7

Chapter

1576 Accesses

Abstract

As the field of nanotechnology advances, many nano-sized materials have been successfully used in drug delivery systems. However, recent practices in offering drugs with long circulation time and efficient targeting, and/or developing new therapeutic strategies are challenging nano-sized drug delivery carriers with more defined biological properties and functionalities. Most nano-sized delivery vehicles and materials currently being used cannot completely fulfill these requirements. To address these issues, syntheses of new carrier materials and modification of existing nano-sized materials with tunable properties are considered to be two effective strategies thus far. In this review article, we will focus on the latter. It is thought that through modification one can control and tailor the properties of nano-sized materials in a predictable manner, as well as provide them with precise properties and functionalities. These modifications can bring new and unique capabilities to many drug delivery systems. Recent progress on drug delivery applications for modified and functionalized nano-sized materials will be highlighted, after the methods used to modify nano-sized materials are discussed briefly.

This is a preview of subscription content, log in via an institution.

Chapter: USD 29.95; Price excludes VAT (USA)

eBook: USD 169.00; Price excludes VAT (USA)

Hardcover Book: USD 219.99; Price excludes VAT (USA)

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

References

Alyautdin, R., D. Gothier et al. European Journal of Pharmaceutics and Biopharmaceutics 41: 44–48 (1995).
CAS Google Scholar
Antony, A. C. Blood 79: 2807–2820 (1992).
PubMed CAS Google Scholar
Artyukhin, A. B., O. Bakajin et al. Langmuir 20: 1442–1448 (2004).
Article PubMed CAS Google Scholar
Bauer, L. A., N. S. Birenbaum et al. Journal of Materials Chemistry 14: 517–526 (2004).
Article CAS Google Scholar
Begley, D. J. Pharmacology & Therapeutics 104: 29–45 (2004).
Article CAS Google Scholar
Bergey, E. J., L. Levy et al. Biomedical Microdevices 4: 293–299 (2002).
Article CAS Google Scholar
Brigger, I., J. Morizet et al. Journal of Pharmacology and Experimental Therapeutics 303: 928–936 (2002).
Article PubMed CAS Google Scholar
Cai, H., Y. Xu et al. Electroanalysis 15: 1864–1870 (2003).
Article CAS Google Scholar
Calvo, P., B. Gouritin et al. European Journal of Neuroscience 15: 1317–1326 (2002).
Article PubMed Google Scholar
Chang, M. C., T. Ikoma et al. Journal of Materials Science-Materials in Medicine 13: 993 997 (2002).
PubMed Google Scholar
Chen, W. and J. Zhang. Journal of Nanoscience and Nanotechnology 6: 1159–1166 (2006).
Article PubMed CAS Google Scholar
Cho, C. S., K. Y. Cho et al. Journal of Controlled Release 77: 7–15 (2001a).
Article PubMed CAS Google Scholar
Cho, C. S., A. Kobayashi et al. Biomaterials 22: 45–51 (2001b).
Article PubMed CAS Google Scholar
Coombes, A. G. A., S. Tasker et al. Biomaterials 18: 1153–1161 (1997).
Article PubMed CAS Google Scholar
Cui, D. X. and H. J. Gao. Biotechnology Progress 19: 683–692 (2003).
Article PubMed CAS Google Scholar
Cui, Z. R., C. H. Hsu et al. Drug Development and Industrial Pharmacy 29: 689–700 (2003).
Article PubMed CAS Google Scholar
Davis, J. J., K. S. Coleman et al. Chemistry-a European Journal 9: 3732–3739 (2003).
Article CAS Google Scholar
Dunn, S. E., A. G. A. Coombes et al. Journal of Controlled Release 44: 65–76 (1997).
Article CAS Google Scholar
Garcia-Garcia, E., K. Andrieux et al. International Journal of Pharmaceutics 298: 274–292 (2005).
Article PubMed CAS Google Scholar
Gref, R., M. Luck et al. Colloids and Surfaces B-Biointerfaces 18: 301–313 (2000).
Article CAS Google Scholar
Gref, R., Y. Minamitake et al. Science 263: 1600–1603 (1994).
Article PubMed CAS Google Scholar
Gref, R., P. Quellec et al. European Journal of Pharmaceutics and Biopharmaceutics 51: 111–118 (2001).
Article PubMed CAS Google Scholar
Gulyaev, A. E., S. E. Gelperina et al. Pharmaceutical Research 16: 1564–1569 (1999).
Article PubMed CAS Google Scholar
Haes, A. J., W. P. Hall et al. Nano Letters 4: 1029–1034 (2004).
Article CAS Google Scholar
Hirabayashi, H., M. Nishikawa et al. Pharmaceutical Research 13: 880–884 (1996).
Article PubMed CAS Google Scholar
Hood, J. D., M. Bednarski et al. Science 296: 2404–2407 (2002).
Article PubMed CAS Google Scholar
Hrapovic, S., Y. L. Liu et al. Analytical Chemistry 76: 1083–1088 (2004).
Article PubMed CAS Google Scholar
Hu, H., Y. C. Ni et al. Nano Letters 4: 507–511 (2004).
Article CAS Google Scholar
Islam, M. F., E. Rojas et al. Nano Letters 3: 269–273 (2003).
Article CAS Google Scholar
K.S. Murthy, Q. M., C.G. Clark Jr. E.E. Remsen, K.L. Wooley. Chem. Commun. 773: 74 (2001).
Google Scholar
Kawashima, Y. Advanced Drug Delivery Reviews 47: 1–2 (2001).
Article PubMed CAS Google Scholar
Kikuchi, M., H. N. Matsumoto et al. Biomaterials 25: 63–69 (2004).
Article PubMed CAS Google Scholar
Kikuchi, M., T. Taguchi et al. In: Bioceramics 14, ed., 449–452 (2002).
Google Scholar
Kobayashi, A., T. Akaike et al. Makromolekulare Chemie-Rapid Communications 7: 645–650 (1986).
Article CAS Google Scholar
Kohler, N., G. E. Fryxell et al. Journal of the American Chemical Society 126: 7206–7211 (2004).
Article PubMed CAS Google Scholar
Kreuter, J. Advanced Drug Delivery Reviews 47: 65–81 (2001).
Article PubMed CAS Google Scholar
Kreuter, J., R. N. Alyautdin et al. Brain Research 674: 171–174 (1995).
Article PubMed CAS Google Scholar
Kreuter, J., V. E. Petrov et al. Journal of Controlled Release 49: 81–87 (1997).
Article CAS Google Scholar
Kreuter, J., P. Ramge et al. Pharmaceutical Research 20: 409–416 (2003).
Article PubMed CAS Google Scholar
Langer, K., C. Coester et al. European Journal of Pharmaceutics and Biopharmaceutics 49: 303–307 (2000).
Article PubMed CAS Google Scholar
Laval, J. M., P. E. Mazeran et al. Analyst 125: 29–33 (1999).
Article Google Scholar
Lee, R. J. and L. Huang. Journal of Biological Chemistry 271: 8481–8487 (1996).
Article PubMed CAS Google Scholar
Lee, R. J. and P. S. Low. Biochimica Et Biophysica Acta-Biomembranes 1233: 134–144 (1995).
Article Google Scholar
Lemieux, P., S. V. Vinogradov et al. Journal of Drug Targeting 8: 91–105 (2000).
Article PubMed CAS Google Scholar
Lin, W., M. C. Garnett et al. Biomaterials 18: 559–565 (1997).
Article PubMed CAS Google Scholar
Lin, W., M. C. Garnett et al. Journal of Controlled Release 71: 117–126 (2001).
Article PubMed CAS Google Scholar
Lin, W., M. C. Garnett et al. International Journal of Pharmaceutics 189: 161–170 (1999).
Article PubMed CAS Google Scholar
Lin, Y., S. Taylor et al. Journal of Materials Chemistry 14: 527–541 (2004).
Article CAS Google Scholar
Lin, Y. H., F. Lu et al. Nano Letters 4: 191–195 (2004).
Article CAS Google Scholar
Mazzola, L. Nature Biotechnology 21: 1137–1143 (2003).
Article PubMed CAS Google Scholar
Moghaddam, M. J., S. Taylor et al. Nano Letters 4: 89–93 (2004).
Article CAS Google Scholar
Moghimi, S. M., A. C. Hunter et al. Pharmacological Reviews 53: 283–318 (2001).
PubMed CAS Google Scholar
Moghimi, S. M. and J. Szebeni. Progress in Lipid Research 42: 463–478 (2003).
Article PubMed CAS Google Scholar
Mosqueira, V. C. F., P. Legrand et al. Biomaterials 22: 2967–2979 (2001b).
Article PubMed CAS Google Scholar
Mosqueira, V. C. F., P. Legrand et al. Pharmaceutical Research 18: 1411–1419 (2001a).
Article PubMed CAS Google Scholar
Muller, R. H., C. Jacobs et al. Advanced Drug Delivery Reviews 47: 3–19 (2001).
Article PubMed CAS Google Scholar
Nakashima, N., Y. Tomonari et al. Chemistry Letters, 638–639 (2002).
Google Scholar
Neal, J. C., S. Stolnik et al. Pharmaceutical Research 15: 318–324 (1998).
Article PubMed CAS Google Scholar
Niemeyer, C. M. Angewandte Chemie-International Edition 40: 4128–4158 (2001).
Article CAS Google Scholar
Olivier, J. C., L. Fenart et al. Pharmaceutical Research 16: 1836–1842 (1999).
Article PubMed CAS Google Scholar
Otsuka, H., Y. Akiyama et al. Journal of the American Chemical Society 123: 8226–8230 (2001).
Article PubMed CAS Google Scholar
Otsuka, H., Y. Nagasaki et al. Advanced Drug Delivery Reviews 55: 403–419 (2003).
Article PubMed CAS Google Scholar
Owens, D. E. and N. A. Peppas. International Journal of Pharmaceutics 307: 93–102 (2006).
Article PubMed CAS Google Scholar
Oyewumi, M. O. and R. J. Mumper. International Journal of Pharmaceutics 251: 85–97 (2003).
Article PubMed CAS Google Scholar
Oyewumi, M. O., R. A. Yokel et al. Journal of Controlled Release 95: 613–626 (2004).
Article PubMed CAS Google Scholar
Pankhurst, Q. A., J. Connolly et al. Journal of Physics D-Applied Physics 36: R167–R181 (2003).
Article CAS Google Scholar
Pardridge, W. M. In: Molecular and Cellular Biology of Neuroprotection in the Cns, A. Christian ed. New York: Plenum, 2002 397–430.
Google Scholar
Park, Y. J., S. H. Nah et al. Journal of Biomedical Materials Research Part A 67A: 751–760 (2003).
CAS Google Scholar
Peracchia, M. T., C. Vauthier et al. Life Sciences 61: 749–761 (1997).
Article PubMed CAS Google Scholar
Q. Zhang, K. L. W. Polym. Prepr. 42: 986–987 (1999).
Google Scholar
Qhobosheane, M., S. Santra et al. Analyst 126: 1274–1278 (2001).
Article PubMed CAS Google Scholar
Quellec, P., R. Gref et al. Journal of Biomedical Materials Research 42: 45–54 (1998).
Article PubMed CAS Google Scholar
Redhead, H. M., S. S. Davis et al. Journal of Controlled Release 70: 353–363 (2001).
Article PubMed CAS Google Scholar
Rouzes, C., R. Gref et al. Journal of Biomedical Materials Research 50: 557–565 (2000).
Article PubMed CAS Google Scholar
Schroder, U. and B. A. Sabel. Brain Research 710: 121–124 (1996).
Article PubMed CAS Google Scholar
Sengupta, S., D. Eavarone et al. Nature 436: 568–572 (2005).
Article PubMed CAS Google Scholar
Sun, W. Q., C. S. Xie et al. Biomaterials 25: 3065–3071 (2004).
Article PubMed CAS Google Scholar
Sun, Y. P., K. F. Fu et al. Accounts of Chemical Research 35: 1096–1104 (2002).
Article PubMed CAS Google Scholar
Takeuchi, H., H. Yamamoto et al. Advanced Drug Delivery Reviews 47: 39–54 (2001).
Article PubMed CAS Google Scholar
Taylor, S., L. W. Qu et al. Biomacromolecules 5: 245–248 (2004).
Article PubMed CAS Google Scholar
Vandorpe, J., E. Schacht et al. Biomaterials 18: 1147–1152 (1997).
Article PubMed CAS Google Scholar
Vinogradov, S. V., E. V. Batrakova et al. Bioconjugate Chemistry 15: 50–60 (2004).
Article PubMed CAS Google Scholar
Vinogradov, S. V., T. K. Bronich et al. Advanced Drug Delivery Reviews 54: 135–147 (2002).
Article PubMed CAS Google Scholar
Wang, S. and P. S. Low. Journal of Controlled Release 53: 39–48 (1998).
Article PubMed CAS Google Scholar
Weitman, S. D., R. H. Lark et al. Cancer Research 52: 3396–3401 (1992).
PubMed CAS Google Scholar
Whitesides, G. M. Nature Biotechnology 21: 1161–1165 (2003).
Article PubMed CAS Google Scholar
Wust, P., B. Hildebrandt et al. Lancet Oncology 3: 487–497 (2002).
Article PubMed CAS Google Scholar
Xu, H., F. Yan et al. Journal of Biomedical Materials Research. Part A 66A: 870–879 (2003).
Article CAS Google Scholar
Younghoon Kim, P. D., David A Christian and D. E. Discher. Nanotechnology 16: S484–491 (2005).
Article CAS Google Scholar
Zambaux, M. F., F. Bonneaux et al. International Journal of Pharmaceutics 212: 1–9 (2001).
Article PubMed CAS Google Scholar
Zhang, C. X., Y. Zhang et al. Analytical Biochemistry 320: 136–140 (2003).
Article PubMed CAS Google Scholar
Zhang, Y., N. Kohler et al. Biomaterials 23: 1553–1561 (2002).
Article PubMed CAS Google Scholar

Download references

Author information

Authors and Affiliations

Department of Bioengineering, Clemson University, Charleston, SC, 29425, USA
Tao Xu, Heather L. Nichols, Ning Zhang & Xuejun Wen
Wake Forest Institute for Regenerative Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, 27157, USA
Tao Xu
Department of Cell Biology and Anatomy, Medical University of South Carolina, Charleston, SC, 29425, USA
Ning Zhang & Xuejun Wen
Department of Orthopedic Surgery, Medical University of South Carolina, Charleston, SC, 29425, USA
Xuejun Wen

Authors

Tao Xu
View author publications
You can also search for this author in PubMed Google Scholar
Heather L. Nichols
View author publications
You can also search for this author in PubMed Google Scholar
Ning Zhang
View author publications
You can also search for this author in PubMed Google Scholar
Xuejun Wen
View author publications
You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Xuejun Wen .

Editor information

Editors and Affiliations

Department of Chemical and Materials Engineering, College of Engineering, University of Cincinnati, Cincinnati, OH, 45221, USA
Donglu Shi
The Institute for Advanced Materials and Nano Biomedicine, Tongji University, Shanghai, 200092, China
Donglu Shi
Research Institute of Micro/Nano Science and Technology, Shanghai Jiao Tong University, Shanghai, 200240, China
Donglu Shi

Rights and permissions

Reprints and permissions

Copyright information

About this chapter

Cite this chapter

Xu, T., Nichols, H.L., Zhang, N., Wen, X. (2009). Modification of Nano-sized Materials for Drug Delivery. In: Shi, D. (eds) NanoScience in Biomedicine. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-49661-8_15

Download citation

DOI: https://doi.org/10.1007/978-3-540-49661-8_15
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-49660-1
Online ISBN: 978-3-540-49661-8
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)

Publish with us

Policies and ethics