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Modeling of Cellular Systems: Application in Stem Cell Research and Computational Disease Modeling

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Book cover Theoretical and Applied Aspects of Systems Biology

Part of the book series: Computational Biology ((COBO,volume 27))

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Abstract

The large-scale development of high-throughput sequencing technologies has allowed the generation of reliable omics data at different regulatory levels. Integrative computational models enable the disentangling of complex interplay between these interconnected levels of regulation by interpreting these large quantities of biomedical information in a systematic way. In the context of human diseases, network modeling of complex gene-gene interactions has been successfully used for understanding disease-related dysregulations and for predicting novel drug targets to revert the diseased phenotype. Furthermore, these computational network models have emerged as a promising tool to dissect the mechanisms of developmental processes such as cellular differentiation, transdifferentiation, and reprogramming. In this chapter, we provide an overview of recent advances in the field of computational modeling of cellular systems and known limitations. A particular attention is paid to highlight the impact of computational modeling on our understanding of stem cell biology and complex multifactorial nature of human diseases and their treatment.

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Authors and Affiliations

  1. Computational Biology Group, Luxembourg Centre for System Biomedicine (LCSB), University of Luxembourg, Luxembourg City, Luxembourg

    Muhammad Ali & Antonio del Sol

  2. Moscow Institute of Physics and Technology, Dolgoprudny, Moscow, Russian Federation

    Antonio del Sol

Authors
  1. Muhammad Ali
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  2. Antonio del Sol
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Corresponding author

Correspondence to Antonio del Sol .

Editor information

Editors and Affiliations

  1. Graduate Program in Computational Biology, Oswaldo Cruz Foundation, Rio de Janeiro, Rio de Janeiro, Brazil

    Fabricio Alves Barbosa da Silva

  2. Graduate Program in Computational Biology, Oswaldo Cruz Foundation, Rio de Janeiro, Rio de Janeiro, Brazil

    Nicolas Carels

  3. Graduate Program in Computational Biology, Oswaldo Cruz Foundation, Rio de Janeiro, Rio de Janeiro, Brazil

    Floriano Paes Silva Junior

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Ali, M., del Sol, A. (2018). Modeling of Cellular Systems: Application in Stem Cell Research and Computational Disease Modeling. In: Alves Barbosa da Silva, F., Carels, N., Paes Silva Junior, F. (eds) Theoretical and Applied Aspects of Systems Biology. Computational Biology, vol 27. Springer, Cham. https://doi.org/10.1007/978-3-319-74974-7_7

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  • DOI: https://doi.org/10.1007/978-3-319-74974-7_7

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-74973-0

  • Online ISBN: 978-3-319-74974-7

  • eBook Packages: Computer ScienceComputer Science (R0)

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