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History of Histamine-Releasing Factor (HRF)/Translationally Controlled Tumor Protein (TCTP) Including a Potential Therapeutic Target in Asthma and Allergy

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TCTP/tpt1 - Remodeling Signaling from Stem Cell to Disease

Part of the book series: Results and Problems in Cell Differentiation ((RESULTS,volume 64))

Abstract

Histamine-releasing factor (HRF) also known as translationally controlled tumor protein (TCTP) is a highly conserved, ubiquitous protein that has both intracellular and extracellular functions. Here we will highlight the subcloning of the molecule, its clinical implications, as well as an inducible-transgenic mouse. Particular attention will be paid to its extracellular functioning and its potential role as a therapeutic target in asthma and allergy. The cells and the cytokines that are produced when stimulated or primed by HRF/TCTP will be detailed as well as the downstream signaling pathway that HRF/TCTP elicits. While it was originally thought that HRF/TCTP interacted with IgE, the finding that cells not binding IgE also respond to HRF/TCTP called this interaction into question. HRF/TCTP or at least its mouse counterpart appears to interact with some, but not all IgE and IgG molecules. HRF/TCTP has been shown to activate multiple human cells including basophils, eosinophils, T cells, and B cells. Since many of the cells that are activated by HRF/TCTP participate in the allergic response, the extracellular functions of HRF/TCTP could exacerbate the allergic, inflammatory cascade. Particularly exciting is that small molecule agonists of the phosphatase SHIP-1 have been shown to modulate the P13 kinase/AKT pathway and may control inflammatory disorders. This review discusses this possibility in light of HRF/TCTP.

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References

  • Alam R, Rozniecki J (1985) A mononuclear cell-derived histamine releasing factor in asthmatic patients.II. Activity in vivo. Allergy 40:124–129

    Article  CAS  PubMed  Google Scholar 

  • Alam R, Rozniecki J, Salmaj K (1984) A mononuclear cell derived histamine releasing factor (HRF) in asthmatic patients. Histamine release from basophils in vitro. Ann Allergy 53:66–69

    CAS  PubMed  Google Scholar 

  • Alam R, Kuna P, Rozniecki J, Kuzminska B (1987) The magnitude of the spontaneous production of histamine-releasing factor (HRF) by lymphocytes in vitro correlates with the state of bronchial hyperreactivity in patients with asthma. J Allergy Clin Immunol 79:103–108

    Article  CAS  PubMed  Google Scholar 

  • Amson R, Pece S, Lespagnol A, Vyas R, Mazzarol G, Tosoni D, Colaluca I, Viale G, Rodrigues-Ferreira S, Wynendaele J, Chaloin O, Hoebeke J, Marine JC, Di Fiore PP, Telerman A (2011) Reciprocal repression between P53 and TCTP. Nat Med 18(1):91–99

    Article  PubMed  Google Scholar 

  • Amzallag N, Passer BJ, Allanic D, Segura E, Théry C, Goud B, Amson R, Telerman A (2004) TSAP6 facilitates the secretion of translationally controlled tumor protein/histamine-releasing factor via a nonclassical pathway. J Biol Chem 279:46104–46112

    Article  CAS  PubMed  Google Scholar 

  • Ando T, Kashiwakura J, Kawakami Y, Kawakami T (2012) Histamine releasing factor (HRF) in asthma and atopic dermatitis. J Immunol 188:177.16 (Abstract)

    Google Scholar 

  • Arcuri F, Papa S, Carducci A, Romagnoli R, Liberatori S, Riparbelli MG, Sanchez JC, Tosi P, del Vecchio MT (2004) Translationally controlled tumor protein (TCTP) in the human prostate and prostate cancer cells: expression, distribution, and calcium binding activity. Prostate 60:130–140

    Article  CAS  PubMed  Google Scholar 

  • Bheekha-Escura R, Chance SR, Langdon JM, MacGlashan DW Jr, MacDonald SM (1999) Pharmacologic regulation of histamine release by the human recombinant histamine-releasing factor. J Allergy Clin Immunol 103:937–943

    Article  CAS  PubMed  Google Scholar 

  • Bheekha-Escura R, MacGlashan DW Jr, Langdon JM, MacDonald SM (2000) Human recombinant histamine-releasing factor activates human eosinophils and the eosinophilic cell line, AML14-3D10. Blood 96:2191–2198

    CAS  PubMed  Google Scholar 

  • Bohm H, Benndorf R, Gaestel M, Gross B, Nurnberg P, Kraft R, Otto A, Bielka H (1989) The growth-related protein P23 of the Ehrlich ascites tumor: translational control, cloning and primary structure. Biochem Int 19:277; Bohm H et al (1991) Biomed. Biochim Acta 12:1193

    Google Scholar 

  • Brauweiler AM, Tamir I, Cambier JC (2000) Bilevel control of B-cell activation by the inositol 5-phosphatase SHIP. Immunol Rev 176:69–74

    Article  CAS  PubMed  Google Scholar 

  • Brunet C, Bédard PM, Lavoie A, Jobin M, Hébert J (1992) Allergic rhinitis to ragweed pollen. II. Modulation of histamine-releasing factor production by specific immunotherapy. J Allergy Clin Immunol 89:87–94

    Article  CAS  PubMed  Google Scholar 

  • Cans C, Passer BJ, Shalak V, Nancy-Portebois V, Crible V, Amzallag N, Allanic D, Tufino R, Argentini M, Moras D, Fiucci G, Goud B, Mirande M, Amson R, Telerman A (2003) Translationally controlled tumor protein acts as a guanine nucleotide dissociation inhibitor on the translation elongation factor eEF1A. Proc Natl Acad Sci U S A 100:13892–13897

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Chen SH, Wu PS, Chou CH, Yan YT, Liu H, Weng SY, Yang-Yen HF (2007) A knockout mouse approach reveals that TCTP functions as an essential factor for cell proliferation and survival in a tissue-or cell type-specific manner. Mol Biol Cell 18:2525–2533

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Chitpatima ST, Makrides S, Bandyopadhyay R, Brawerman G (1988) Nucleotide sequence of a major messenger RNA for a 21 kilodalton polypeptide that is under translational control in mouse tumor cells. Nucleic Acids Res 16:2350

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Chung S, Kim M, Choi W, Chung J, Lee K (2000) Expression of translationally controlled tumor protein mRNA in human colon cancer. Cancer Lett 156:185–190

    Article  CAS  PubMed  Google Scholar 

  • Didichenko SA, Spiegl N, Brunner T, Dahinden CA (2008) IL-3 induces a Pim1-dependent antiapototic pathway in primary human basophils. Blood 112:3949–3958

    Article  CAS  PubMed  Google Scholar 

  • Dombrowicz D, Flamand V, Brigman KK, Koller BH, Kinet JP (1993) Abolition of anaphylaxis by targeted disruption of the high affinity immunoglobulin E receptor alpha chain gene. Cell 75:969–976

    Article  CAS  PubMed  Google Scholar 

  • Fenner BJ, Scannell M, Prehn JH (2010) Expanding the substantial interactome of NEMO using protein microarrays. PLoS One 5:e8799

    Article  PubMed  PubMed Central  Google Scholar 

  • Gachet Y, Tournier S, Lee M, Lazaris-Karatzas A, Poulton T, Bommer UA (1999) The growth-related, translationally controlled protein P23 has properties of a tubulin binding protein and associates transiently with microtubules during the cell cycle. J Cell Sci 112:1257–1271

    CAS  PubMed  Google Scholar 

  • Gnanasekar M, Rao KV, Chen L, Narayanan RB, Geetha M, Scott AL, Ramaswamy K, Kaliraj P (2002) Molecular characterization of a calcium binding translationally controlled tumor protein homologue from the filarial parasites Brugia malayi and Wuchereria bancrofti. Mol Biochem Parasitol 121:107–118

    Article  CAS  PubMed  Google Scholar 

  • Huber M, Helgason CD, Damen JE, Liu L, Humphries K, Krustal G (1998) The src homology 2 containing inositol phosphatase (SHIP) is the gatekeeper of mast cell degranulation. Proc Natl Acad Sci U S A 95:11330–11335

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Jacobsen EA, Ochkur SI, Pero RS, Taranova AG, Protheroe CA, Colbert DC, Lee NA, Lee JJ (2008) Allergic pulmonary inflammation in mice is dependent on eosinophil-induced recruitment of effector T cells. J Exp Med 205:699–710

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kang HS, Lee MJ, Song H, Han SH, Kim YM, Im JY, Choi I (2001) Molecular identification of IgE-dependent histamine-releasing factor as a B cell growth factor. J Immunol 166:6545–6554

    Article  CAS  PubMed  Google Scholar 

  • Kashiwakura J, Ando T, Matsumoto K, Kimura M, Kitaura J, Matho MH, Zajonc DM, Ozeki T, Ra C, MacDonald SM, Siraganian RP, Broide DH, Kawakami Y, Kawakami T (2012) Proinflammatory role of histamine-releasing factor in mouse models of asthma and allergy. J Clin Invest 122:218–228

    Article  CAS  PubMed  Google Scholar 

  • Kepley CL, Youssef L, Andrews RP, Wilson BS, Oliver JM (1999) Syk deficiency in nonreleaser basophils. J Allergy Clin Immunol 104:279–284

    Article  CAS  PubMed  Google Scholar 

  • Korkmaz KS, Elbi C, Korkmaz CG, Loda M, Hager GL, Saatcioglu F (2002) Molecular cloning and characterization of STAMP1, a highly prostate-specific six transmembrane protein that is overexpressed in prostate cancer. J Biol Chem 277:36689–36696

    Article  CAS  PubMed  Google Scholar 

  • Krystal G (2000) Lipid phosphatases in the immune system. Immunology 12:397–403

    CAS  Google Scholar 

  • Kuna P, Alam R, Kuzminska B, Rozniecki J (1989) The effect of preseasonal immunotherapy on the production of histamine-releasing factor (HRF) by mononuclear cells from patients with seasonal asthma: results of a double-blind, placebo-controlled, randomized study. J Allergy Clin Immunol 83:816–882

    Article  CAS  PubMed  Google Scholar 

  • Langdon J, Anders K, Lichtenstein LM, MacDonald SM (1995) Atopics translate mRNA for the IgE-dependent histamine releasing factor (HRF) more effectively than normal. J Allergy Clin Immunol 95:336 (Abstract)

    Google Scholar 

  • Langdon JM, Vonakis BM, MacDonald SM (2004) Identification of the interaction between the human recombinant histamine releasing factor/translationally controlled tumor protein and elongation factor-1 delta (also known as elongation factor-1B beta). Biochem Biophys Acta 1688:232–236

    CAS  PubMed  Google Scholar 

  • Langdon JM, Schroeder JT, Vonakis BM, Bieneman AP, Chichester K, MacDonald SM (2008) Histamine-releasing factor/translationally controlled tumor protein (HRF/TCTP)-induced histamine release is enhanced with SHIP-1 knockdown in cultured human mast cell and basophil models. J Leukoc Biol 84:1151–1158

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Lavens-Phillips SE, MacGlashan DW Jr (2000) The tyrosine kinases p563/56lyn and p72syk are differentially expressed at the protein level but not at the messenger RNA level in nonreleasing human basophils. Am J Respir Cell Mol Biol 23:566–571

    Article  CAS  PubMed  Google Scholar 

  • Leaker BR, Barnes PJ, O’Connor BJ, Ali FY, Tam P, Neville J, Mackenzie LF, MacRury T (2014) The effects of the novel SHIP1 activator AQX-1125 on allergen-induced responses in mild-to-moderate asthma. Clin Exp Allergy 44(9):1146–1153

    Article  CAS  PubMed  Google Scholar 

  • Lee JJ, Dimina D, Macias MP, Ochkur SI, McGarry MP, O’Neill KR, Protheroe C, Pero R, Nguyen T, Cormier SA, Lenkiewicz E, Colbert D, Rinaldi L, Ackerman SJ, Irvin CG, Lee NA (2004) Defining a link with asthma in mice congenitally deficient in eosinophils. Science 305:1773–1776

    Article  CAS  PubMed  Google Scholar 

  • Li F, Zhang D, Fujise K (2001) Characterization of fortilin, a novel antiapoptotic protein. J Biol Chem 276:47542–47549

    Article  CAS  PubMed  Google Scholar 

  • Lioubin MN, Algate PA, Tsai S, Carlberg K, Aebersold A, Rohrschneider LR (1996) p150Ship, a signal transduction molecule with inositol polyphosphate-5-phosphatase activity. Genes Dev 10:1084–1095

    Article  CAS  PubMed  Google Scholar 

  • MacDonald SM (1993) Histamine releasing factors and IgE heterogeneity. In: Middleton E, Reed CE, Ellis EF, Adkinson NF, Yunginger JW, Buss WW (eds) Allergy: principles and practice, 4th edn. Mosby-Year Book, St. Louis, MO, pp 1–11

    Google Scholar 

  • MacDonald SM (1996) Histamine-releasing factors. Curr Opin Immunol 8:778–783

    Article  CAS  PubMed  Google Scholar 

  • MacDonald SM, Kagey-Sobotk A, Proud D, Naclerio RM, Lichtenstein LM (1987a) Histamine-releasing factor: release mechanism and responding population. J Allergy Clin Immunol 79:248

    Google Scholar 

  • MacDonald SM, Lichtenstein LM, Proud D, Plaut M, Kagey-Sobotka A (1987b) Studies of IgE-dependent histamine releasing factors: heterogeneity of IgE. J Immunol 139:506–512

    CAS  PubMed  Google Scholar 

  • MacDonald SM, Rafnar T, Langdon J, Lichtenstein LM (1995) Molecular identification of an IgE-dependent histamine releasing factor. Science 269:688–690

    Article  CAS  PubMed  Google Scholar 

  • MacDonald SM, Schleimer RP, Kagey-Sobotka A, Gillis S, Lichtenstein LM (1989) Recombinant IL-3 induces histamine release from human basophils. J Immunol 142:3527–3532

    CAS  PubMed  Google Scholar 

  • MacDonald SM, White JM, Kagey-Sobotka A, MacGlashan DW Jr, Lichtenstein LM (1991) The heterogeneity of human IgE exemplified by the passive transfer of D2O sensitivity. Clin Exp Allergy 21:133–138

    Article  CAS  PubMed  Google Scholar 

  • MacDonald SM, Bhisutthibhan J, Shapiro TA, Rogerson SJ, Taylor TE, Tembo M, Langdon JM, Meshnick SR (2001) Immune mimicry in malaria: Plasmodium falciparum secretes a functional histamine-releasing factor homolog in vitro and in vivo. Proc Natl Acad Sci U S A 98:10829–10832

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Mayr SI, Zuberi RI, Zhang M, de Sousa-Hitzler J, Ngo K, Kuwabara Y, Yu L, Fung-Leung WP, Liu FT (2002) IgE-dependent mast cell activation potentiates airway responses in murine asthma models. J Immunol 169:2061–2068

    Article  CAS  PubMed  Google Scholar 

  • Min B, Paul W (2008) Basophils and type 2 immunity. Curr Opin Hematol 15:59–63

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Miura K, Lavens-Phillips S, MacGlashan DW Jr (2001) Localizing a control region in the pathway to LTC4 secretion following stimulation of human basophils with anti-IgE antibody. J Immunol 167:7027–7037

    Article  CAS  PubMed  Google Scholar 

  • Miura K, Schroeder JT, Hubbard WC, MacGlashan DW Jr (1999) Extracellular signal-regulated kinases regulate leukotriene C4 generation, but not histamine release or IL-4 production from human basophils. J Immunol 162:4198–4206

    CAS  PubMed  Google Scholar 

  • Moldes M, Lasnier F, Gauthereau X, Klein C, Pairault J, Fève B, Chambaut-Guérin AM (2001) Tumor necrosis factor-alpha-induced adipose-related protein (TIARP), a cell-surface that is highly induced by tumor necrosis factor-alpha and adipose conversion. J Biol Chem 276:33938–33946

    Article  CAS  PubMed  Google Scholar 

  • Obata K, Mukai K, Tsujimura Y, Ishiwata K, Kawano Y, Minegishi Y, Watanabe N, Karasuyama H (2007) Basophils are essential initiators of a novel type of chronic allergic inflammation. Blood 110:913–920

    Article  CAS  PubMed  Google Scholar 

  • Oettgen HC, Martin TR, Wynshaw-Boris A, Deng C, Drazen JM, Leder P (1994) Active anaphylaxis in IgE-deficient mice. Nature 370:367–370

    Article  CAS  PubMed  Google Scholar 

  • Ong CJ, Ming-Lum A, Nodwell M, Ghanipour A, Yang L, Williams DE, Kim J, Demirjian L, Qasimi P, Ruschmann J, Cao LP, Ma K, Chung SW, Duronio V, Andersen RJ, Krystal G, Mui AL (2007) Small-molecule agonists of SHIP1 inhibit the phosphoinositide 3-kinase pathway in hematopoietic cells. Blood 110:1942–1949

    Article  CAS  PubMed  Google Scholar 

  • Rao KV, Chen L, Gnanasekar M, Ramaswamy K (2002) Cloning and characterization of a calcium-binding histamine-releasing protein from Schistosoma mansoni. J Biol Chem 277:31207–31213

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Rho SB, Lee JH, Park MS, Byun HJ, Kang S, Seo SS, Kim JY, Park SY (2011) Anti-apoptotic protein TCTP controls the stability of the tumor suppressor p53. FEBS Lett 585:29–35

    Article  CAS  PubMed  Google Scholar 

  • Rid R, Onder K, Trost A, Bauer J, Hintner H, Ritter M, Jakab M, Costa I, Reischl W, Richter K, MacDonald S, Jendrach M, Bereiter-Hahn J, Breitenbach M (2010) H2O2-dependent translocation of TCTP into the nucleus enables its interaction with VDR in human keratinocytes: TCTP as a further module in calcitriol signalling. J Steroid Biochem Mol Biol 118:29–40

    Article  CAS  PubMed  Google Scholar 

  • Rohrschneider LR, Fuller JF, Wolf I, Liu Y, Lucas DM (2000) Structure, function and biology of SHIP proteins. Genes Dev 14:505–520

    CAS  PubMed  Google Scholar 

  • Ruschmann J, Antignano F, Lam V, Snyder K, Kim C, Essak M, Zhang A, Lin AH, Mali RS, Kapur R, Krystal G (2012) The role of SHIP in the development and activation of mouse mucosal and connective tissue mast cells. J Immunol 188:3839–3850

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Sampson HA, Broadbent KR, Bernhisel-Broadbent J (1989) Spontaneous release of histamine from basophils and histamine-releasing factor in patients with atopic dermatitis and food hypersensitivity. N Engl J Med 321:228–232

    Article  CAS  PubMed  Google Scholar 

  • Scharenberg AM, Kinet J-P (1998) PtdIns-3,4,5-P3: a regulatory nexus between tyrosine kinases and sustained calcium signals. Cell 94:5–8

    Article  CAS  PubMed  Google Scholar 

  • Schroeder JT (2009) Basophils: beyond effector cells of allergic inflammation. Adv Immunol 101:123–161

    Article  CAS  PubMed  Google Scholar 

  • Schroeder JT, Lichtenstein LM, MacDonald SM (1996) An immunoglobulin E-dependent recombinant histamine releasing factor induces IL-4 secretion from human basophils. J Exp Med 183:1265–1270

    Article  CAS  PubMed  Google Scholar 

  • Schroeder JT, Lichtenstein LM, MacDonald SM (1997) Recombinant histamine-releasing factor enhances IgE dependent IL-4 and IL-13 secretion by human basophils. J Immunol 159:447–452

    CAS  PubMed  Google Scholar 

  • Seder RA, Paul WE, Dvorak AM, Sharkis SJ, Kagey-Sobotka A, Niv Y, Finkelman FD, Barbieri SA, Galli SJ, Plaut M (1991) Mouse splenic and bone marrow cell populations that express high-affinity Fc epsilon receptors and produce interleukin 4 are highly enriched in basophils. Proc Natl Acad Sci U S A 88:2835–2839

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Smith DB, Johnson KS (1988) Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase. Gene 67:31–40

    Article  CAS  PubMed  Google Scholar 

  • Stenton GR, Mackenzie LF, Tam P, Cross JL, Harwig C, Raymond J, Toews J, Chernoff D, MacRury T, Szabo C (2013a) Characterization of AQX-1125, a small-molecule SHIP1 activator: part 2. Efficacy studies in allergic and pulmonary inflammation models in vivo. Br J Pharmacol 168(6):1519–1529

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Stenton GR, Mackenzie LF, Tam P, Cross JL, Harwig C, Raymond J, Toews J, Wu J, Ogden N, MacRury T, Szabo C (2013b) Characterization of AQX-1125, a small-molecule SHIP1 activator: part 1. Effects on inflammatory cell activation and chemotaxis in vitro and pharmacokinetic characterization in vivo. Br J Pharmacol 168(6):1506–1518

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Sundstrom C, Nilsson K (1976) Establishment and characterization of a human histiocytic lymphoma cell line (U-937). Int J Cancer 17:565–577

    Article  CAS  PubMed  Google Scholar 

  • Susini L, Besse S, Duflaut D, Lespagnol A, Beekman C, Fiucci G, Atkinson AR, Busso D, Poussin P, Marine JC, Martinou JC, Cavarelli J, Moras D, Amson R, Telerman A (2008) TCTP protects from apoptotic cell death by antagonizing bax function. Cell Death Differ 15:1211–1220

    Article  CAS  PubMed  Google Scholar 

  • Tam P, Mackenzie LF, Toews J, Stenton GR, Harwig C, Raymond J, Szabo C, MacRury T, Chernoff D (2012) Absorption, pharmacokinetics, metabolism, distribution and tolerability of AQX-1125, a SHIP1 activator clinical development candidate, in healthy humans volunteers: comparison with dogs and rats. ATS Abstract, May

    Google Scholar 

  • Telerman A, Amson R (2009) The molecular programme of tumour reversion: the steps beyond malignant transformation. Nat Rev Cancer 9(3):206–215

    Article  CAS  PubMed  Google Scholar 

  • Thébault S, Agez M, Chi X, Stojko J, Cura V, Telerman SB, Maillet L, Gautier F, Billas-Massobrio I, Birck C, Troffer-Charlier N, Karafin T, Honoré J, Senff-Ribeiro A, Montessuit S, Johnson CM, Juin P, Cianférani S, Martinou JC, Andrews DW, Amson R, Telerman A, Cavarelli J (2016) TCTP contains a BH3-like domain, which instead of inhibiting, activates Bcl-xL. Sci Rep 6(19725):1–11

    Google Scholar 

  • Thueson DO, Speck LS, Lett-Brown MA, Grant JA (1979) Histamine releasing activity (HRA). I. Production by mitogen- or antigen-stimulated human mononuclear cells. J Immunol 123:628–631

    Google Scholar 

  • Tuynder M, Fiucci G, Prieur S, Lespagnol A, Géant A, Beaucourt S, Duflaut D, Besse S, Susini L, Cavarelli J, Moras D, Amson R, Telerman A (2004) Translationally controlled tumor protein is a target of tumor reversion. Proc Natl Acad Sci U S A 101:15364–15369

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Vercoutter-Edouart AS, Czeszak X, Crépin M, Lemoine J, Boilly B, Le Bourhis X, Peyrat JP, Hondermarck H (2001) Proteomic detection of changes in protein synthesis induced by fibroblast growth factor-2 in MCF-7 human breast cancer cells. Exp Cell Res 262:59–68

    Article  CAS  PubMed  Google Scholar 

  • Vilarino N, MacGlashan D Jr (2005) Transient transfection of human peripheral blood basophils. J Immunol Methods 296:11–18

    Article  CAS  PubMed  Google Scholar 

  • Vilariño N, Miura K, MacGlashan DW Jr (2005) Acute IL-3 priming up-regulates the stimulus-induced Raf-1-Mek-Erk cascade independently of IL-3-induced activation of Erk. J Immunol 175:3006–3014

    Article  PubMed  Google Scholar 

  • Vonakis BM, Gibbons S Jr, Sora R, Langdon JM, MacDonald SM (2001) Src homology 2 domain-containing inositol 5’ phosphatase is negatively associated with histamine release to human recombinant histamine releasing factor in human basophils. J Allergy Clin Immunol 108:822–831

    Article  CAS  PubMed  Google Scholar 

  • Vonakis BM, MacGlashan DW Jr, Vilariño N, Langdon JM, Scott RS, MacDonald SM (2008) Distinct characteristics of signal transduction events by histamine releasing factor/translationally controlled tumor protein (HRF/TCTP)-Induced Priming and Activation of Human Basophils. Blood 111:1789–1796

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Vonakis BM, Sora R, Langdon JM, Casolaro V, MacDonald SM (2003) Inhibition of cytokine gene transcription by the human recombinant histamine-releasing factor in human T lymphocytes. J Immunol 17:3742–3750

    Article  Google Scholar 

  • Vonakis BM, Vasagar K, Gibbons SP Jr, Gober L, Sterba PM, Chang H, Saini SS (2007) Basophil FcepsilonRI histamine release parallels expression of Src-homology 2-containing inositol phosphatases in chronic idiopathic urticaria. J Allergy Clin Immunol 119:441–448

    Article  CAS  PubMed  Google Scholar 

  • Wantke F, MacGlashan DW Jr, Langdon JM, MacDonald SM (1999) The human recombinant histamine releasing factor: Functional evidence that it does not bind to the IgE molecule. J Allergy Clin Immunol 103:642–648

    Article  CAS  PubMed  Google Scholar 

  • Xu A, Bellamy AR, Taylor JA (1999) Expression of translationally controlled tumour protein is regulated by calcium at both the transcriptional and post-transcriptional level. Biochemist 3:683–689

    Article  Google Scholar 

  • Yang Y, Yang F, Xiong Z, Yan Y, Wang X, Nishino M, Mirkovic D, Nguyen J, Wang H, Yang XF (2005) An N-terminal region of translationally controlled tumor protein is required for its antiapoptotic activity. Oncogene 24:4778–4788

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Yenofsky R, Cereghini S, Krowczynska A, Brawerman G (1983) Regulation of mRNA utilization in mouse erythroleukemia cells induced to differentiate by exposure to dimethyl sulfoxide. Mol Cell Biol 3:1197–1203

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Yoneda K, Rokutan K, Nakamura Y, Yanagawa H, Kondo-Teshima S, Sone S (2004) Stimulation of human bronchial epithelial cells by IgE-dependent histamine-releasing factor. Am J Phys Lung Cell Mol Phys 286:L174–L181

    CAS  Google Scholar 

  • Yueh-Chiao Y, Xie L, Langdon JM, Myers AC, Oh SY, Zhu Z, Macdonald SM (2010) The effects of overespression of histamine releasing factor (HRF) in a transgenic mouse model. PLoS One 5:1–12

    Google Scholar 

  • Zhang D, Li F, Weidner D, Mnjoyan ZH, Fujise K (2002) Physical and functional interaction between myeloid cell leukemia 1 protein (MCL1) and Fortilin. The potential role of MCL1 as a fortilin chaperone. J Biol Chem 277:37430–37438

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. The Johns Hopkins Asthma and Allergy Center, 5501 Hopkins Bayview Circle, Room 3B.69, Baltimore, MD, 21224, USA

    Susan M. MacDonald M.D.

  2. Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA

    Susan M. MacDonald M.D.

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Correspondence to Susan M. MacDonald M.D. .

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  1. Bâtiment B2M, Institut Gustave Roussy, Villejuif, Val-de-Marne, France

    Adam Telerman

  2. Bâtiment B2M, Institut Gustave Roussy, Villejuif, Val-de-Marne, France

    Robert Amson

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MacDonald, S.M. (2017). History of Histamine-Releasing Factor (HRF)/Translationally Controlled Tumor Protein (TCTP) Including a Potential Therapeutic Target in Asthma and Allergy. In: Telerman, A., Amson, R. (eds) TCTP/tpt1 - Remodeling Signaling from Stem Cell to Disease. Results and Problems in Cell Differentiation, vol 64. Springer, Cham. https://doi.org/10.1007/978-3-319-67591-6_16

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