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Elusive Role of TCTP Protein and mRNA in Cell Cycle and Cytoskeleton Regulation

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TCTP/tpt1 - Remodeling Signaling from Stem Cell to Disease

Part of the book series: Results and Problems in Cell Differentiation ((RESULTS,volume 64))

Abstract

Translationally Controlled Tumor-associated Protein (TCTP) is a small, 23 kDa multifunctional and ubiquitous protein localized both in the cytoplasm and in the nucleus of eukaryotic cells. It is evolutionarily highly conserved. Certain aspects of its structure show remarkable similarities to guanine nucleotide-free chaperons Mss4 and Dss4 suggesting that at least some functions of TCTP may depend on its chaperon-like action on other proteins. Besides other functions, TCTP is clearly involved in cell cycle regulation. It is also regulated in a cell-cycle-dependent manner suggesting a reciprocal interaction between this protein and the cell cycle-regulating machinery. TCTP also interacts with the cytoskeleton, mostly with actin microfilaments (MFs) and microtubules (MTs). It regulates the cytoskeleton organization and through this action it also influences cell shape and motility. The exact role of TCTP in cell cycle and cytoskeleton regulation is certainly not fully understood. In this chapter, we summarize recent data on cell cycle and cytoskeletal aspects of TCTP regulatory role.

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Author information

Authors and Affiliations

  1. Institute of Genetics and Development of Rennes (IGDR), Cell Cycle Group, CNRS, UMR 6290, 35043, Rennes, France

    Jacek Z. Kubiak

  2. Faculty of Medicine, University Rennes 1, UEB, IFR 140, 35043, Rennes, France

    Jacek Z. Kubiak

  3. Laboratory of Regenerative Medicine and Cell Biology, Military Institute of Hygiene and Epidemiology (WIHE), Warsaw, Poland

    Jacek Z. Kubiak

  4. The Houston Methodist Research Institute, Houston, TX, USA

    Malgorzata Kloc

  5. Department of Surgery, The Houston Methodist Hospital, Houston, TX, USA

    Malgorzata Kloc

  6. University of Texas, MD Anderson Cancer Center, Houston, TX, USA

    Malgorzata Kloc

Authors
  1. Jacek Z. Kubiak
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  2. Malgorzata Kloc
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Correspondence to Jacek Z. Kubiak .

Editor information

Editors and Affiliations

  1. Bâtiment B2M, Institut Gustave Roussy, Villejuif, Val-de-Marne, France

    Adam Telerman

  2. Bâtiment B2M, Institut Gustave Roussy, Villejuif, Val-de-Marne, France

    Robert Amson

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Kubiak, J.Z., Kloc, M. (2017). Elusive Role of TCTP Protein and mRNA in Cell Cycle and Cytoskeleton Regulation. In: Telerman, A., Amson, R. (eds) TCTP/tpt1 - Remodeling Signaling from Stem Cell to Disease. Results and Problems in Cell Differentiation, vol 64. Springer, Cham. https://doi.org/10.1007/978-3-319-67591-6_11

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