Abstract
Nausea and diarrhea are common yet inconsistent side effects of abdominal and pelvic irradiation. Their frequency, chronicity, and severity vary greatly, and the reasons for inter-subject variability are unknown. We studied the potential for radiation-induced changes in amino acid absorption and mucosal barrier function to lead to gastrointestinal toxicity. We found profound and prolonged changes in the absorption and secretion of several electrolytes and nutrients, caused by changes in transporter function, after radiation doses as low as 1 to 3 Gy. After identifying absorbed and non-absorbed amino acids, we demonstrated the role of a beneficial amino acid drink to alleviate radiation-related gastrointestinal symptoms in a mouse model.
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Acknowledgments
This research was supported by the National Space Biomedical Research Institute through NASA NCC 9-58 and Entrinsic Health Solutions (P0018160). Drs. Vidyasagar and Okunieff have shares in Entrinsic Health Solutions and hold scientific advisor positions within the company.
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Yin, L., Vaught, L., Okunieff, P., Casey-Sawicki, K., Vidyasagar, S. (2017). Amino Acid Hydration Decreases Radiation-Induced Nausea in Mice: A Pica Model. In: Halpern, H., LaManna, J., Harrison, D., Epel, B. (eds) Oxygen Transport to Tissue XXXIX. Advances in Experimental Medicine and Biology, vol 977. Springer, Cham. https://doi.org/10.1007/978-3-319-55231-6_9
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DOI: https://doi.org/10.1007/978-3-319-55231-6_9
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