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Structure of Functional Neuropilin-Centred Class 3 Semaphorin and VEGF Receptors

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The Neuropilins: Role and Function in Health and Disease

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Abstract

Neuropilin functions as a co-receptor for multiple cell surface signalling systems; in particular it regulates VEGF and semaphorin signalling through their respective receptors. The molecular characteristics of neuropilin, the VEGF and semaphorin signalling complexes and their multiple interaction modes have been extensively investigated by structural and biophysical analyses. Much has been learned about the molecular mechanisms by which neuropilin acts as an interaction hub, but the complexities of neuropilin function still pose many questions.

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Acknowledgement

EYJ is funded by Cancer Research UK (A10976), the UK Medical Research Council (G9900061) and the Wellcome Trust (grant 090532/Z/09/Z supporting the Wellcome Trust Centre for Human Genetics).

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  1. Division of Structural Biology, The Wellcome Trust Centre for Human Genetics,University of Oxford, Roosevelt Drive, Oxford, OX3 7BN, UK

    E. Yvonne Jones

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Correspondence to E. Yvonne Jones .

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  1. Department Anatomy and Cell Biology, Israel Institute of Technology Technion, Haifa, Israel

    Gera Neufeld

  2. Department Anatomy and Cell Biology, Israel Institute of Technology Technion, Haifa, Israel

    Ofra Kessler

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Jones, E.Y. (2017). Structure of Functional Neuropilin-Centred Class 3 Semaphorin and VEGF Receptors. In: Neufeld, G., Kessler, O. (eds) The Neuropilins: Role and Function in Health and Disease. Springer, Cham. https://doi.org/10.1007/978-3-319-48824-0_2

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