Abstract
Quantitative analysis of the interactions between nanomaterials and their surrounding environment is crucial for safety evaluation in the application of nanotechnology as well as its development and standardization. In this chapter, we demonstrate the importance of the adsorption of surrounding molecules onto the surface of nanomaterials by forming biocorona and thus impact the bio-identity and fate of those materials. We illustrate the key factors including various physical forces in determining the interaction happening at bio-nano interfaces. We further discuss the mathematical endeavors in explaining and predicting the adsorption phenomena, and propose a new statistics-based surface adsorption model, the Biological Surface Adsorption Index (BSAI), to quantitatively analyze the interaction profile of surface adsorption of a large group of small organic molecules onto nanomaterials with varying surface physicochemical properties, first employing five descriptors representing the surface energy profile of the nanomaterials, then further incorporating traditional semi-empirical adsorption models to address concentration effects of solutes. These Advancements in surface adsorption modelling showed a promising development in the application of quantitative predictive models in biological applications, nanomedicine, and environmental safety assessment of nanomaterials.
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References
Unsworth LD, Sheardown H, Brash JL (2005) Protein resistance of surfaces prepared by sorption of end-thiolated poly(ethylene Glycol) to gold: effect of surface chain density. Langmuir 21:1036–1041
Tilton RD, Robertson CR, Gast AP (1991) Manipulation of hydrophobic interactions in protein adsorption. Langmuir 7:2710–2718
Gubala V, Siegrist J, Monaghan R, O’Reilly B, Gandhiraman RP, Daniels S, Williams DE, Ducrée J (2013) Simple approach to study biomolecule adsorption in polymeric microfluidic channels. Anal Chim Acta 760:75–82
An Inventory of Nanotechnology-based Consumer Products Introduced on the Market. http://www.nanotechproject.org/cpi/. Accessed 26 Nov 2014
Serra A, Filippo E, Re M, Palmisano M, Vittori-Antisari M, Buccolieri A, Manno D (2009) Non-functionalized silver nanoparticles for a localized surface plasmon resonance-based glucose sensor. Nanotechnology 20:165501
Yigit MV, Zhu L, Ifediba MA, Zhang Y, Carr K, Moore A, Medarova Z (2011) Noninvasive MRI-SERS imaging in living mice using an innately bimodal nanomaterial. ACS Nano 5:1056–1066
Willets KA, Van Duyne RP (2007) Localized surface plasmon resonance spectroscopy and sensing. Annu Rev Phys Chem 58:267–297
Sund J, Alenius H, Vippola M, Savolainen K, Puustinen A (2011) Proteomic characterization of engineered nanomaterial-protein interactions in relation to surface reactivity. ACS Nano 5:4300–4309
Lynch I, Dawson KA (2008) Protein-nanoparticle interactions. Nano Today 3:40–47
Lynch I, Cedervall T, Lundqvist M, Cabaleiro-Lago C, Linse S, Dawson KA (2007) The nanoparticle-protein complex as a biological entity; a complex fluids and surface science challenge for the 21st century. Adv Colloid Interface Sci 134–135:167–174
Chen R, Choudhary P, Schurr RN, Bhattacharya P, Brown JM, Ke PC (2012) Interaction of lipid vesicle with silver nanoparticle-serum albumin protein corona. Appl Phys Lett 100:013703
Chen R, Radic S, Choudhary P, Ledwell KG, Huang G, Brown JM, Ke PC (2012) Formation and cell translocation of carbon nanotube-fibrinogen protein corona. Appl Phys Lett 101:133702
Vroman L, Mattson JS, Smith CA (1974) Surface charge, protein adsorption, and thrombosis. Science 184:585–586
Li Y, Neoh KG, Kang E-T (2004) Plasma protein adsorption and thrombus formation on surface functionalized polypyrrole with and without electrical stimulation. J Colloid Interface Sci 275:488–495
Missirlis PYF, Lemm DW (1991) Protein adsorption and thrombus formation. In: Missirlis PYF, Lemm DW (eds) Modern aspects of protein adsorption on biomaterials. Springer Netherlands, Dordrecht, pp. 219–248
Pitt WG, Park K, Cooper SL (1986) Sequential protein adsorption and thrombus deposition on polymeric biomaterials. J Colloid Interface Sci 111:343–362
Lim C, Slack S, Ufer S, Lindner E (2004) Protein adsorption to planar electrochemical sensors and sensor materials. Pure Appl Chem 76:754–764
Frederix F, Bonroy K, Reekmans G, Laureyn W, Campitelli A, Abramov MA, Dehaen W, Maes G (2004) Reduced nonspecific adsorption on covalently immobilized protein surfaces using poly(ethylene Oxide) containing blocking agents. J Biochem Biophys Methods 58:67–74
Russo CJ, Passmore LA (2014) Controlling protein adsorption on graphene for cryo-EM using low-energy hydrogen plasmas. Nat Methods 11:649–652
Andrade JD, Hlady V (1986) Protein adsorption and materials biocompatibility: a tutorial review and suggested hypotheses. In: Biopolymers/non-exclusion HPLC; advances in polymer science. Springer, Berlin/Heidelberg, pp. 1–63
Le X, Poinern G, Jai r E, Ali N, Berry CM, Fawcett D (2013) Engineering a biocompatible scaffold with either micrometre or nanometre scale surface topography for promoting protein adsorption and cellular response. Int J Biomater 2013:e782549
Ratnikova TA, Govindan PN, Salonen E, Ke PC (2011) In vitro polymerization of microtubules with a fullerene derivative. ACS Nano 5:6306–6314
Zuo G, Zhou X, Huang Q, Fang H, Zhou R (2011) Adsorption of villin headpiece onto graphene, carbon nanotube, and C60: effect of contacting surface curvatures on binding affinity. J Phys Chem C 115:23323–23328
Zuo G, Kang S-G, Xiu P, Zhao Y, Zhou R (2013) Interactions between proteins and carbon-based nanoparticles: exploring the origin of nanotoxicity at the molecular level. Small 9:1546–1556
Zuo G, Fang H, Zhou R (2011) Nanotoxicity : Exploring the Interactions Between Carbon Nanotubes and Proteins. In: Carbon Nanotubes-Growth and Applications. Naraghi M (ed). InTech: Rijeka, Croatia
Tournus F, Latil S, Heggie M, Charlier J-C (2005) π-stacking interaction between carbon nanotubes and organic molecules. Phys Rev B 72:075431
Zuo G, Huang Q, Wei G, Zhou R, Fang H (2010) Plugging into proteins: poisoning protein function by a hydrophobic nanoparticle. ACS Nano 4:7508–7514
Prakash J, Nirmalakhandan N, Speece RE (1994) Prediction of activated carbon adsorption isotherms for organic vapors. Environ Sci Technol 28:1403–1409
Nirmalakhandan NN, Speece RE (1993) Prediction of activated carbon adsorption capacities for organic vapors using quantitative structure-activity relationship methods. Environ Sci Technol 27:1512–1516
Urano K, Omori S, Yamamoto E (1982) Prediction method for adsorption capacities of commercial activated carbons in removal of organic vapors. Environ Sci Technol 16:10–14
Reucroft PJ, Simpson WH, Jonas LA (1971) Sorption properties of activated carbon. J Phys Chem 75:3526–3531
Apul OG, Wang Q, Shao T, Rieck JR, Karanfil T (2013) Predictive model development for adsorption of aromatic contaminants by multi-walled carbon nanotubes. Environ Sci Technol 47:2295–2303
Nel AE, Mädler L, Velegol D, Xia T, Hoek EMV, Somasundaran P, Klaessig F, Castranova V, Thompson M (2009) Understanding biophysicochemical interactions at the nano–bio Interface. Nat Mater 8:543–557
Xia X-R, Monteiro-Riviere NA, Riviere JE (2010) An index for characterization of nanomaterials in biological systems. Nat Nanotechnol 5:671–675
Xia XR, Monteiro-Riviere NA, Mathur S, Song X, Xiao L, Oldenberg SJ, Fadeel B, Riviere JE (2011) Mapping the surface adsorption forces of nanomaterials in biological systems. ACS Nano 5:9074–9081
Chen R, Zhang Y, Darabi Sahneh F, Scoglio CM, Wohlleben W, Haase A, Monteiro-Riviere NA, Riviere JE (2014) Nanoparticle surface characterization and clustering through concentration-dependent surface adsorption modeling. ACS Nano 8:9446–9456
Ke PC, Lamm MH (2011) A biophysical perspective of understanding nanoparticles at large. Phys Chem Chem Phys 13:7273–7283
Podila R, Chen R, Ke PC, Brown JM, Rao AM (2012) Effects of surface functional groups on the formation of nanoparticle-protein corona. Appl Phys Lett 101:263701
Wen Y, Geitner NK, Chen R, Ding F, Chen P, Andorfer RE, Govindan PN, Ke PC (2013) Binding of cytoskeletal proteins with silver nanoparticles. RSC Adv 3:22002–22007
Stone A (2013) The theory of intermolecular forces. Oxford University Press
Karelson M (2000) Molecular descriptors in QSAR/QSPR. Wiley-Interscience, New York
Hansch C, Fujita T (1964) ρ-σ-π analysis. A method for the correlation of biological activity and chemical structure. J Am Chem Soc 86:1616–1626
Hansch C (1993) Quantitative structure-activity relationships and the unnamed science. Acc Chem Res 26:147–153
Giaginis C, Tsantili-Kakoulidou A (2008) Alternative measures of lipophilicity: from octanol–water partitioning to IAM retention. J Pharm Sci 97:2984–3004
Pan B, Xing B (2008) Adsorption mechanisms of organic chemicals on carbon nanotubes. Environ Sci Technol 42:9005–9013
Kostarelos K, Bianco A, Prato M (2009) Promises, facts and challenges for carbon nanotubes in imaging and therapeutics. Nat Nanotechnol 4:627–633
Shvedova AA, Kisin ER, Porter D, Schulte P, Kagan VE, Fadeel B, Castranova V (2009) Mechanisms of pulmonary toxicity and medical applications of carbon nanotubes: two faces of janus? Pharmacol Ther 121:192–204
Bianco A, Kostarelos K, Prato M (2005) Applications of carbon nanotubes in drug delivery. Curr Opin Chem Biol 9:674–679
Beg S, Rizwan M, Sheikh AM, Hasnain MS, Anwer K, Kohli K (2011) Advancement in carbon nanotubes: basics, biomedical applications and toxicity. J Pharm Pharmacol 63:141–163
Zhang Y, Bai Y, Yan B (2010) Functionalized carbon nanotubes for potential medicinal applications. Drug Discov Today 15:428–435
Gramatica P (2007) Principles of QSAR models validation: internal and external. QSAR Comb Sci 26:694–701
Dearden JC, Cronin MTD, Kaiser KLE (2009) How not to develop a quantitative structure–activity or structure–property relationship (QSAR/QSPR). SAR QSAR Environ Res 20:241–266
Gramatica P, Giani E, Papa E (2007) Statistical external validation and consensus modeling: a QSPR case study for Koc prediction. J Mol Graph Model 25:755–766
Jolliffe IT (2002) Principal component analysis. Springer Science & Business Media, New York
Kaufhold S, Dohrmann R, Klinkenberg M, Siegesmund S, Ufer K (2010) N2-BET specific surface area of bentonites. J Colloid Interface Sci 349:275–282
Pettibone JM, Cwiertny DM, Scherer M, Grassian VH (2008) Adsorption of organic acids on TiO2 nanoparticles: effects of pH, nanoparticle size, and nanoparticle aggregation. Langmuir 24:6659–6667
Gilbert B, Ono RK, Ching KA, Kim CS (2009) The effects of nanoparticle aggregation processes on aggregate structure and metal uptake. J Colloid Interface Sci 339:285–295
Do DD (1998) Adsorption analysis: equilibria and kinetics. Imperial College Press, London
Shih Y-H, Gschwend PM (2009) Evaluating activated carbon-water sorption coefficients of organic compounds using a linear solvation energy relationship approach and sorbate chemical activities. Environ Sci Technol 43:851–857
Zhao Q, Yang K, Li W, Xing B (2014) Concentration-dependent polyparameter linear free energy relationships to predict organic compound sorption on carbon nanotubes. Sci Rep 4:3888–3888
Comer J, Chen R, Poblete H, Vergara-Jaque A, Riviere JE (2015) Predicting adsorption affinities of small molecules on carbon nanotubes using molecular dynamics simulation. ACS Nano 9:11761–11774
Leenaerts O, Partoens B, Peeters FM (2009) Water on graphene: hydrophobicity and dipole moment using density functional theory. Phys Rev B 79:235440
Ruthven DM (1984) Principles of adsorption and adsorption processes. John Wiley & Sons, New York
Wu W, Chen W, Lin D, Yang K (2012) Influence of surface oxidation of multiwalled carbon nanotubes on the adsorption affinity and capacity of polar and nonpolar organic compounds in aqueous phase. Environ Sci Technol 46:5446–5454
Yang K, Xing B (2010) Adsorption of organic compounds by carbon nanomaterials in aqueous phase: polanyi theory and its application. Chem Rev 110:5989–6008
Shaw SY, Westly EC, Pittet MJ, Subramanian A, Schreiber SL, Weissleder R (2008) Perturbational profiling of nanomaterial biologic activity. Proc Natl Acad Sci 105:7387–7392
Epa VC, Burden FR, Tassa C, Weissleder R, Shaw S, Winkler DA (2012) Modeling biological activities of nanoparticles. Nano Lett 12:5808–5812
Winkler DA, Burden FR, Yan B, Weissleder R, Tassa C, Shaw S, Epa VC (2014) Modelling and predicting the biological effects of nanomaterials. SAR QSAR Environ Res 25:161–172
Le T, Epa VC, Burden FR, Winkler DA (2012) Quantitative structure–property relationship modeling of diverse materials properties. Chem Rev 112:2889–2919
Liu X, Tang K, Harper S, Harper B, Steevens J, Xu R (2013) Predictive Modeling of Nanomaterial Exposure Effects in Biological Systems. Int J Nanomedicine 8:31–43
Le TC, Mulet X, Burden FR, Winkler DA (2013) Predicting the complex phase behavior of self-assembling drug delivery nanoparticles. Mol Pharm 10:1368–1377
Liu G, Lin Y (2005) Electrochemical sensor for organophosphate pesticides and nerve agents using zirconia nanoparticles as selective sorbents. Anal Chem 77:5894–5901
Zhang W, Asiri AM, Liu D, Du D, Lin Y (2014) Nanomaterial-based biosensors for environmental and biological monitoring of organophosphorus pesticides and nerve agents. Trends Anal Chem 54:1–10
Zhou J-H, Deng C-Y, Si S-H, Wang S-E (2010) Zirconia electrodeposited on a self-assembled monolayer on a gold electrode for sensitive determination of parathion. Microchim Acta 172:207–215
Behnam R, Morshed M, Tavanai H, Ghiaci M (2013) Destructive adsorption of diazinon pesticide by activated carbon nanofibers containing Al2O3 and MgO nanoparticles. Bull Environ Contam Toxicol 91:475–480
Moradi Dehaghi S, Rahmanifar B, Moradi AM, Azar PA (2014) Removal of permethrin pesticide from water by chitosan–zinc oxide nanoparticles composite as an adsorbent. J Saudi Chem Soc 18:348–355
Saifuddin N, Nian CY, Zhan LW, Ning KX (2011) Chitosan-silver nanoparticles composite as point-of-use drinking water filtration system for household to remove pesticides in water. Asian J Biochem 6:142–159
Bootharaju MS, Pradeep T (2012) Understanding the degradation pathway of the pesticide. Chlorpyrifos by noble metal nanoparticles. Langmuir 28:2671–2679
Sreekumaran NAN, Pradeep T A method for decontaminating water containing pesticides. EP1715947 B1, August 22, 2012
Manimegalai G, Shanthakumar S, Sharma C (2014) Silver nanoparticles: synthesis and application in mineralization of pesticides using membrane support. Int Nano Lett 4:1–5
Basahel SN, Ali TT, Mokhtar M, Narasimharao K (2015) Influence of crystal structure of nanosized ZrO2 on photocatalytic degradation of methyl orange. Nanoscale Res Lett 10:73
Barakat NAM, Nassar MM, Farrag TE, Mahmoud MS (2013) Effective photodegradation of methomyl pesticide in concentrated solutions by novel enhancement of the photocatalytic activity of TiO2 using CdSO4 nanoparticles. Environ Sci Pollut Res 21:1425–1435
Lowry GV (2007) Nanomaterials for groundwater remediation. In: Environmental nanotechnology: applications and impacts of nanomaterials. McGraw-Hill Professional, New York
Chen R, Zhang Y, Monteiro-Riviere NA, Riviere JE (2016) Quantification of nanoparticle pesticide adsorption: computational approaches based on experimental data. Nanotoxicology 10:1118–1128
Lam C, James JT, McCluskey R, Arepalli S, Hunter RL (2006) A review of carbon nanotube toxicity and assessment of potential occupational and environmental health risks. Crit Rev Toxicol 36:189–217
Pulskamp K, Diabaté S, Krug HF (2007) Carbon nanotubes show no sign of acute toxicity but induce intracellular reactive oxygen species in dependence on contaminants. Toxicol Lett 168:58–74
Rana S, Yeh Y-C, Rotello VM (2010) Engineering the nanoparticle–protein interface: applications and possibilities. Curr Opin Chem Biol 14:828–834
Salvador-Morales C, Flahaut E, Sim E, Sloan J, Green ML, Sim RB (2006) Complement activation and protein adsorption by carbon nanotubes. Mol Immunol 43:193–201
Rybak-Smith MJ, Sim RB (2011) Complement activation by carbon nanotubes. Adv Drug Deliv Rev 63:1031–1041
Andersen AJ, Robinson JT, Dai H, Hunter AC, Andresen TL, Moghimi SM (2013) Single-walled carbon nanotube surface control of complement recognition and activation. ACS Nano 7:1108–1119
Lynch I, Dawson KA, Linse S (2006) Detecting cryptic epitopes created by nanoparticles. Sci Signal 2006:pe14–pe14
Aillon KL, Xie Y, El-Gendy N, Berkland CJ, Forrest ML (2009) Effects of nanomaterial physicochemical properties on in vivo toxicity. Adv Drug Deliv Rev 61:457–466
Walkey CD, Olsen JB, Song F, Liu R, Guo H, Olsen DWH, Cohen Y, Emili A, Chan WCW (2014) Protein corona fingerprinting predicts the cellular interaction of gold and silver nanoparticles. ACS Nano 8:2439–2455
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Chen, R., Riviere, J.E. (2017). Biological Surface Adsorption Index of Nanomaterials: Modelling Surface Interactions of Nanomaterials with Biomolecules. In: Tran, L., Bañares, M., Rallo, R. (eds) Modelling the Toxicity of Nanoparticles. Advances in Experimental Medicine and Biology, vol 947. Springer, Cham. https://doi.org/10.1007/978-3-319-47754-1_8
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