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Development of Nanocellulose-Based Bioinks for 3D Bioprinting of Soft Tissue

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Book cover 3D Printing and Biofabrication

Part of the book series: Reference Series in Biomedical Engineering ((TIENRE))

Abstract

3D bioprinting technology is expected to revolutionize the field of medicine and health care particularly within soft tissue repair and reconstruction. Surgical needs for soft tissue repair include nose, ear, meniscus, and cartilage in joints, as well as repair of damaged nerve tissue, and repair or replacement of damaged skin. 3D bioprinting technology includes a 3D bioprinter, cells, and bioink. Novel bioinks which will be suitable for soft tissue repair need to be developed before 3D bioprinting technology can get into the clinic. Hydrogels and cell-laden hydrogels are very attractive for soft tissue application because of the similarity of mechanical properties and cell environment. The process of design and development of novel bioinks is described in detail in this chapter which includes rheology, printability, cross-linking, long-term stability in medium, cell viability, and stimulation of cells during tissue growth. The commercialization process of bioinks is also described.

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Authors and Affiliations

  1. Chalmers University of Technology, 3D Bioprinting center Väst (BBV), Göteborg, Sweden

    Paul Gatenholm, Hector Martinez, Erdem Karabulut, Kajsa Markstedt & Ida Henriksson

  2. Sahlgrenska University Hospital, Plastic Surgery, Göteborg, Sweden

    Matteo Amoroso & Lars Kölby

  3. CELLINK AB, Arvid Wallgrens backe 20, Göteborg, Sweden

    Hector Martinez & Erik Gatenholm

Authors
  1. Paul Gatenholm
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  2. Hector Martinez
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  3. Erdem Karabulut
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  4. Matteo Amoroso
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  5. Lars Kölby
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  6. Kajsa Markstedt
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  7. Erik Gatenholm
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  8. Ida Henriksson
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Corresponding author

Correspondence to Paul Gatenholm .

Editor information

Editors and Affiliations

  1. Group Inst. of Materials Science a. Techology, Technische Universität Wien Group Inst. of Materials Sci. a. Techn., Wien, Austria

    Aleksandr Ovsianikov

  2. Institute for Regenerative Medicine, Wake Forest School of Medicine Institute for Regenerative Medicine, Winston-Salem, North Carolina, USA

    James Yoo

  3. 3D Bioprinting Solutions (3D Bio) , Moscow, Russia

    Vladimir Mironov

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Gatenholm, P. et al. (2016). Development of Nanocellulose-Based Bioinks for 3D Bioprinting of Soft Tissue. In: Ovsianikov, A., Yoo, J., Mironov, V. (eds) 3D Printing and Biofabrication. Reference Series in Biomedical Engineering(). Springer, Cham. https://doi.org/10.1007/978-3-319-40498-1_14-1

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  • DOI: https://doi.org/10.1007/978-3-319-40498-1_14-1

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  • Publisher Name: Springer, Cham

  • Online ISBN: 978-3-319-40498-1

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