Abstract
With the emerging nanotechnology, nanoscaled materials have drawn much attention to wide research communities for many years. Nanoscaled fibrous materials offer a multitude of fascinating features such as high surface area-to-volume ratio and tuneable porosity, making them attractive for widespread applications. Among different methods for nanofibre fabrication, electrospinning is a simple and versatile process for generating ultrathin fibres from a variety of polymeric materials or composites. This chapter gives a holistic review on current approaches and developments in electrospinning and its future trends in manufacturing advanced materials.
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References
Ellison CJ, Phatak A, Giles DW, Macosko CW, Bates FS (2007) Melt blown nanofibers: fiber diameter distributions and onset of fiber breakup. Polymer 48:3306–3316
Li H, Ke Y, Hu Y (2006) Polymer nanofibers prepared by template melt extrusion. J Appl Polym Sci 99:1018–1023
Ma PX, Zhang R (1999) Synthetic nano-scale fibrous extracellular matrix. J Biomed Mater Res 46:60–72
Yang Z, Xu B (2007) Supramolecular hydrogels based on biofunctional nanofibers of self-assembled small molecules. J Mater Chem 17:2385–2393
Reneker DH, Chun I (1996) Nanometre diameter fibres of polymer, produced by electrospinning. Nanotechnology 7:216–223
Bhardwaj N, Kundu SC (2010) Electrospinning: a fascinating fiber fabrication technique. Biotechnol Adv 28:325–347
Baji A, Mai Y-W, Wong S-C, Abtahi M, Chen P (2010) Electrospinning of polymer nanofibers: effects on oriented morphology, structures and tensile properties. Compos Sci Technol 70:703–718
Chronakis IS (2005) Novel nanocomposites and nanoceramics based on polymer nanofibers using electrospinning process—A review. J Mater Process Technol 167:283–293
Lannutti J, Reneker D, Ma T, Tomasko D, Farson D (2007) Electrospinning for tissue engineering scaffolds. Mat Sci Eng C Mater 27:504–509
Zeng J, Yang L, Liang Q, Zhang X, Guan H, Xu C, Chen X, Jing X (2005) Influence of the drug compatibility with polymer solution on the release kinetics of electrospun fiber formulation. J Controlled Release 105:43–51
Kenawy E-R, Bowlin GL, Mansfield K, Layman J, Simpson DG, Sanders EH, Wnek GE (2002) Release of tetracycline hydrochloride from electrospun poly(ethylene-co-vinylacetate), poly(lactic acid), and a blend. J Controlled Release 81:57–64
Khil M-S, Cha D-I, Kim H-Y, Kim I-S, Bhattarai N (2003) Electrospun nanofibrous polyurethane membrane as wound dressing. J Biomed Mater Res Part B 67B:675–679
Gorji M, Jeddi AAA, Gharehaghaji AA (2012) Fabrication and characterization of polyurethane electrospun nanofiber membranes for protective clothing applications. J Appl Polym Sci 125:4135–4141
Qin X-H, Wang S-Y (2006) Filtration properties of electrospinning nanofibers. J Appl Polym Sci 102:1285–1290
Fong H (2004) Electrospun nylon 6 nanofiber reinforced BIS-GMA/TEGDMA dental restorative composite resins. Polymer 45:2427–2432
Lee SW, Choi SW, Jo SM, Chin BD, Kim DY, Lee KY (2006) Electrochemical properties and cycle performance of electrospun poly(vinylidene fluoride) based fibrous membrane electrolytes for Li-ion polymer battery. J Power Sources 163:41–46
Pinto NJ, Johnson AT, MacDiarmid AG, Mueller CH, Theofylaktos N, Robinson DC, Miranda FA (2003) Electrospun polyaniline/polyethylene oxide nanofiber field-effect transistor. Appl Phys Lett 83(20):4244–4246
Zhang G, Kataphinan W, Teye-Mensah R, Katta P, Khatri L, Evans EA, Chase GG, Ramsier RD, Reneker DH (2005) Electrospun nanofibers for potential space-based applications. Mater Sci Eng B-Adv Funct Solid-State Mater 116(3):353–358
Xiang J, Chu Y, Zhang X, Shen X (2012) Magnetic and microwave absorption properties of electrospun Co0.5Ni0.5 Fe2O4 nanofibers. Appl Surf Sci 263:320–325
Rafiei S, Maghsoodloo S, Noroozi B, Mottaghitalab V, Haghi AK (2013) Mathematical modeling in electrospinning process of nanofibers: a detailed review. Cellulose Chem Technol 47(5–6):323–338
Morton WJ (1902) US patent, 705691
Cooley JF (1902) US patent, 692631
Zeleny J (1914) Phys Rev 3:69–91
Formhals A (1934) US patent, 1975504
Taylor GI (1969) Electrically driven jets. Proc R Soc Lond A Math Phys Sci (1934–1990) 313:453–475
Larrondo L, St John Manley R (1981) Electrostatic fiber spinning from polymer melts. I. Experimental observations on fiber formation and properties. J Polym Sci Polym Phys Ed 19:909–920
Li D, Xia Y (2004) Electrospinning of nanofibers: reinventing the wheel? Adv Mater 16:1151–1170
Hu X, Liu S, Zhou G, Huang Y, Xie Z, Jing X (2014) Electrospinning of polymeric nanofibers for drug delivery applications. J Control Release 185:12–21
Wang L, Liu X, Hou Z, Li C, Yang P, Cheng Z, Lian H, Lin J (2008) Electrospinning Synthesis and Luminescence Properties of One-Dimensional Zn2SiO4:Mn2+ Microfibers and Microbelts. J Phys Chem C 112:18882–18888
Alves da Silva ML, Martins A, Costa-Pinto AR, Costa P, Faria S, Gomes M, Reis RL, Neves NM (2010) Cartilage tissue engineering using electrospun PCL nanofiber meshes and MSCs. Biomacromolecules 11:3228–3236
Jin Y, Yang D, Kang D, Jiang X (2009) Fabrication of necklace-like structures via electrospinning. Langmuir 26(2):1186–1190
Koombhongse S, Liu W, Reneker DH (2001) Flat polymer ribbons and other shapes by electrospinning. J Polym Sci Part B Polym Phys 39:2598–2606
Nguyen TT, Ghosh C, Hwang SG, Chanunpanich N, Park JS (2012) Porous core/sheath composite nanofibers fabricated by coaxial electrospinning as a potential mat for drug release system. Int J Pharm 439:296–306
Dror Y, Salalha W, Avrahami R, Zussman E, Yarin A, Dersch R, Greiner A, Wendorff J (2007) One-step production of polymeric microtubes by co-electrospinning. Small 3:1064–1073
Zhao Y, Cao X, Jiang L (2007) Bio-mimic multichannel microtubes by a facile method. J Am Chem Soc 129:764–765
Agarwal S, Wendorff JH, Greiner A (2009) Progress in the field of electrospinning for tissue engineering applications. Adv Mater 21:3343–3351
Zanin MHA, Cerize NNP, de Oliveira AM (2011) Production of nanofibers by electrospinning technology: overview and application in cosmetics. In: Beck R, Guterres S, Pohlmann A (eds) Nanocosmetics and nanomedicines new approaches for skin Care. Springer, Berlin, pp 311–332
Liang D, Hsiao BS, Chu B (2007) Functional electrospun nanofibrous scaffolds for biomedical applications. Adv Drug Deliv Rev 59(14):1392–1412
Haider S, Al-Zeghayer Y, Ahmed Ali FA, Haider A, Mahmood A, Al-Masry WA, Imran M, Aijaz MO (2013) Highly aligned narrow diameter chitosan electrospun nanofibers. J Polym Res 20(105):1–11
Rho KS, Jeong L, Lee G, Seo BM, Park YJ, Hong S-D, Roh S, Cho JJ, Park WH, Min B-M (2006) Electrospinning of collagen nanofibers: effects on the behavior of normal human keratinocytes and early-stage wound healing. Biomaterials 27:1452–1461
Maleknia L, Rezazadeh Majidi Z (2014) Electrospinning of gelatin nanofiber for biomedical application. Orient J Chem 30(4):2043–2048
Bai S, Han H, Huang X, Xu W, Kaplan DL, Zhu H, Lu Q (2015) Silk scaffolds with tunable mechanical capability for cell differentiation. Acta Biomater 20:22–31
Baker S, Sigley J, Helms CC, Stitzel J, Berry J, Bonin K, Guthold M (2012) The mechanical properties of dry, electrospun fibrinogen fibers. Mater Sci Eng B 32:215–221
Wang X, Zhao H, Turng L-S, Li Q (2013) Crystalline morphology of electrospun poly (ε-caprolactone) (PCL) nanofibers. Ind Eng Chem Res 52:4939–4949
Natarajan L, New J, Dasari A, Yu S, Manan MA (2014) Surface morphology of electrospun PLA fibers: mechanisms of pore formation. RSC Adv 4:44082–44088
Park JC, Ito T, Kim K-O, Kim KW, Kim BS, Khil MS, Kim HY, Kim IS (2010) Electrospun poly (vinyl alcohol) nanofibers: effects of degree of hydrolysis and enhanced water stability. Polym J 42:273–276
Chuangchote S, Sagawa T, Yoshikawa S (2009) Electrospinning of poly(vinyl pyrrolidone): effects of solvents on electrospinnability for the fabrication of poly(p-phenylene vinylene) and TiO2 nanofibers. J Appl Polym Sci 114:2777–2791
Wang R, Liu Y, Li B, Hsiao BS, Chu B (2012) Electrospun nanofibrous membranes for high flux microfiltration. J Membr Sci 392–393:167–174
Zhang H, Zhang L, Jia Q, Shi C, Yang J (2015) Preparation of porous nylon 6 fiber via electrospinning. Polym Eng Sci 55(5):1133–1141
Veleirinho B, Lopes-da-Silva JA (2009) Application of electrospun poly (ethylene terephthalate) nanofiber mat to apple juice clarification. Process Biochem 44:353–356
Vlad S, Ciobanu C, Macocinschi D, Filip D, Butnaru M, Gradinaru LM, Nistor A (2010) Polyurethane nanofibers by electrospinning for biomedical applications. CAS Proc 2:353–356
Chisca S, Irina Barzic A, Sava I, Olaru N, Bruma M (2012) Morphological and rheological insights on polyimide chain entanglements for electrospinning produced fibers. J Phys Chem B 116:9082–9088
Xu C, Xu F, Wang B, Lu T (2011) Electrospinning of poly(ethylene-co-vinyl-alcohol) nanofibres encapsulated with Ag nanoparticles for wound healing. J Nanomater 2011, Article ID 201834
Han SO, Youk JH, Min KD, Kang YO, Park WH (2008) Electrospinning of cellulose acetate nanofibers using a mixed solvent of acetic acid/water: effects of solvent composition on the fiber diameter. Mater Lett 62:759–762
Boland ED, Wnek GE, Simpson DG, Pawlowski KJ, Bowlin GL (2001) Tailoring tissue engineering scaffolds using electrostatic processing techniques: a study of poly(glycolic acid) electrospinning. J Macromol Sci Pure 38:1231–1243
Gensheimer M, Becker M, Heep AB, Wendorff LH, Thauer RK, Greiner A (2007) Novel biohybrid materials by electrospinning: nanofibers of poly(ethylene oxide) and living bacteria. Adv Mater 19:2480–2482
Fang J, Zhang L, Sutton D, Wang X, Lin T (2012) Needleless melt-electrospinning of polypropylene nanofibres. J Nanomater 2012, Article ID 382639
Wang X, Niu H, Lin T (2009) Needleless electrospinning of nanofibers with a conical wire coil. Polym Eng Sci 49:1582–1586
Nayak R, Padhye R, Kyratzis IL, Truong YB, Arnold L (2011) Recent advances in nanofibre fabrication techniques. Text Res J 82(2):129–147
Hunley MT, Karikari AS, McKee MG, Mather BD, Layman JM, Fornof AR, Long TE (2008) Taking advantage of tailored electrostatics and complementary hydrogen bonding in the design of nanostructures for biomedical applications. Macromol Symp 270:1–7
Tian S, Ogata N, Shimada N, Nakane K, Ogihara T, Yu M (2009) Melt electrospinning from poly(L-lactide) rods coated with poly(ethylene-co-vinyl alcohol). J Appl Polym Sci 113:1282–1288
Hutmacher DW, Dalton PD (2011) Melt electrospinning. Chem Asian J 6(1):44–56
Muerza-Cascante ML, Haylock D, Hutmacher DW, Dalton PD (2015) Melt electrospinning and its technologization in tissue engineering. Tissue Eng Part B Rev 21(2):187–202
Farrugia BL, Brown TD, Upton Z, Hutmacher DW, Dalton PD, Dargaville TR (2013) Dermal fibroblast infiltration of poly (ε-caprolactone) scaffolds fabricated by melt electrospinning in a direct writing mode. Biofabrication 5:025001
Li H, Chen H, Zhong X, Wu W, Ding Y, Yang W (2014) Interjet distance in needleless melt differential electrospinning with umbellate nozzles. J Appl Polym Sci 131:40515
Zhmayev E, Cho D, Joo YL (2010) Nanofibers from gas assisted polymer melt electrospinning. Polymer 51:4140–4144
Ogata N, Shimada N, Yamaguchi S, Nakane K, Ogihara T (2007) Melt-electrospinning of poly(ethylene terephthalate) and polyalirate. J Appl Polym Sci 105:1127–1132
Nayak R, Kyratzis IL, Truong YB, Padhye R, Arnold L (2012) Melt-electrospinning of polypropylene with conductive additives. J Mater Sci 47:6387–6396
Lyons J, Li C, Ko F (2004) Melt-electrospinning part I: processing parameters and geometric properties. Polymer 45:7597–7603
Detta N, Brown TD, Edin FK, Albrecht K, Chiellini F, Chiellini E, Dalton PD, Hutmacher DW (2010) Melt electrospinning of polycaprolactone and its blends with poly(ethylene glycol). Polym Int 59:1558–1562
Góra A, Sahay R, Thavasi V, Ramakrishna S (2011) Melt-electrospun fibers for advances in biomedical engineering, clean energy, filtration, and separation. Polym Rev 51:265–287
Dalton P, Grafahrend D, Klinkhammer K, Klee D, Moller M (2007) Electrospinning of polymer melts: phenomenological observations. Polymer 48:6823–6833
Yoon YI, Park KE, Lee SJ, Park WH (2013) Fabrication of microfibrous and nano-/microfibrous scaffolds: melt and hybrid electrospinning and surface modification of poly(L-lactic acid) with plasticizer. Biomed Res Int 2013:30904
Chen Z, He J, Zhao F, Liu Y, Liu Y, Yuan H (2014) Effect of polar additives on melt electrospinning of non-polar polypropylene. J Serb Chem Soc 79:587–596
Hochleitner G, Jungst T, Brown TD, Hahn K, Moseke C, Jakob F, Dalton PD, Groll J (2015) Additive manufacturing of scaffolds with sub-micron filaments via melt electrospinning writing. Biofabrication 7:035002
Brown TD, Edin F, Detta N, Skelton AD, Hutmacher DW, Dalton PD (2014) Melt electrospinning of poly(ε-caprolactone) scaffolds: phenomenological observations associated with collection and direct writing. Mater Sci Eng C 45:698–708
Zhou H, Green TB, Joo YL (2006) The thermal effects on electrospinning of polylactic acid melts. Polymer 47:7497–7505
Ko J, Mohtaram NK, Lee PCD, Willerth SM, Jun MB (2013) Parametric studies of melt electrospinning poly-e-(caprolactone) fibers for tissue engineering applications. In: 8th ICOMM, 25–28 March 2013, pp 526–531
Lin T (2012) Needleless Electrospinning: a practical way to mass production of nanofibers. J Textile Sci Eng 2(6):1–3
Simm W, Gosling C, Bonart R, Falkai BV (1979) US patent, 4143196
Jirsak O, Sanetrnik F, Lukas D, Kotek V, Martinova L, Chaloupek J (2005) WO 2005/024101 A1
Yarin A, Zussman E (2004) Upward needleless electrospinning of multiple nanofibers. Polymer 45:2977–2980
Thoppey NM, Bochinski JR, Clarke LI, Gorga RE (2011) Edge electrospinning for high throughput production of quality nanofibers. Nanotechnology 22:345301
Thoppey NM, Bochinski JR, Clarke LI, Gorga RE (2010) Unconfined fluid electrospun into high quality nanofibers from a plate edge. Polymer 51:4928–4936
Tang S, Zeng Y, Wang X (2010) Splashing needleless electrospinning of nanofibers 50:2252–2257
Lu B, Wang Y, Liu Y, Duan H, Zhou J, Zhang Z, Wang Y, Li X, Wang W, Lan W, Xie E (2010) Superhigh-throughput needleless electrospinning using a rotary cone as spinneret. Small 6:1612–1616
Niu H, Lin T (2012) Fiber generators in needleless electrospinning. J Nanomater 2012, Article ID 725950
Green TB, King SL, Li L (2011) US 2011/0223330 A1
Liu Y, He JH (2007) Bubble electrospinning for mass production of nanofibers. Int J Nonlinear Sci Numer Simul 8:393–396
Yang R, He J, Xu L, Yu J (2009) Bubble-electrospinning for fabricating nanofibers. Polymer 50:5846–5850
Liu Y, Ren Z-F, He J-H (2010) Bubble electrospinning method for preparation of aligned nanofibre mat. Mater Sci Technol 26:1309–1312
Liu Y, Dong L, Fan J, Wang R, Yu JY (2011) Effect of applied voltage on diameter and morphology of ultrafine fibers in bubble electrospinning. J Appl Polym Sci 120:592–598
Wu D, Huang X, Lai X, Sun D, Lin L (2010) High throughput tip-less electrospinning via a circular cylindrical electrode. J Nanosci Nanotechnol 10:4221–4226
Wang X, Hu XW, Qiu XC, Huang X, Wu D, Sun D (2013) An improved tip-less electrospinning with strip-distributed solution delivery for massive production of uniform polymer nanofibers. Mater Lett 99:21–23
Yamashita Y, Ko F, Tanaka A, Miyake H (2007) Characteristics of elastomeric nanofiber membranes produced by electrospinning. J Textile Eng 53:137–142
Vaseashta A (2007) Controlled formation of multiple Taylor cones in electrospinning process. Appl Phys Lett 90:093115
Ding B, Kimura E, Sato T, Fujita S, Shiratori S (2004) Fabrication of blend biodegradable nanofibrous nonwoven mats via multi-jet electrospinning. Polymer 45:1895–1902
Theron SA, Yarin AL, Zussman E, Kroll E (2005) Multiple jets in electrospinning: experiment and modeling. Polymer 46:2889–2899
Tomaszewski W, Szadkowski M (2005) Investigation of electrospinning with the use of a multi-jet electrospinning head. Fibres Text East Eur 13:22–26
Zheng Y, Hugh Gong R, Zeng Y (2015) Multijet motion and deviation in electrospinning. RSC Adv 5:48533–48540
Yang Y, Jia Z, Hou L, Liu J, Wang L, Guan Z (2010) A shield ring enhanced equilateral hexagon distributed multi-needle electrospinning spinneret. IEEE Trans Dielectr Electr Insul 17:1592–1601
Xie S, Zeng Y (2012) Effects of electric field on multineedle electrospinning: experiment and simulation study. Ind Eng Chem Res 51:5336–5345
Angammana CJ, Jayaram SH (2011) The effects of electric field on the multijet electrospinning process and fiber morphology. IEEE Trans Dielectr Electr Insul 47:1028–1035
Yamashita Y, Ko F, Miyake H, Higashiyama A (2008) Establishment of nanofiber preparation technique by electrospinning. Sen’i Gakkaishi 64:24–28
Varesano A, Rombaldoni F, Mazzuchetti G, Tonin C, Comotto R (2010) Multi-jet nozzle electrospinning on textile substrates: observations on process and nanofibre mat deposition. Polym Int 59:1606–1615
Varabhas JS, Chase GG, Reneker DH (2008) Electrospun nanofibers from a porous hollow tube. Polymer 49:4226–4229
Dosunmu OO, Chase GG, Kataphinan W, Reneker DH (2006) Electrospinning of polymer nanofibres from multiple jets on a porous tubular surface. Nanotechnology 17:1123–1127
Zheng Y, Liu X, Zeng Y (2013) Electrospun nanofibers from a multihole spinneret with uniform electric field. J Appl Polym Sci 130:3221–3228
Zheng Y, Zeng Y (2014) Electric field analysis of spinneret design for multihole electrospinning system. J Mater Sci 49:1964–1972
Wang X, Um I, Fang D, Okamoto A, Hsiao B, Chu B (2005) Formation of water-resistant hyaluronic acid nanofibers by blowing-assisted electro-spinning and non-toxic post treatments. Polymer 46:4853–4867
Kim YM, Ahn KR, Sung YB (2003) KR Patent WO03080905
Arora P, Chen G, Frisk S, Graham D, Marin R, Suh H (2009) US Patent 2009/0261035
Ahmad B, Stride E, Stoyanov S, Pelan E, Edirisinghe M (2012) Electrospinning of ethyl cellulose fibres with a heated needle and heated air using a co-axial needle: a comparison. J Med Biol Eng 1:1–3
Wang X, Lin T, Wang X (2014) 3D electric field analysis of needleless electrospinning from a ring coil. J Ind Text 44:463–476
Bubakir MM, Li H, Wu W, Li X, Ma S, Yang W (2014) Applications of web produced by hot air assisted melt differential electrospinning method. IOP conf ser Mater Sci Eng 64:012052
Liao CC, Hou SS, Wang CC, Chen CY (2010) Electrospinning fabrication of partially crystalline bisphenol A polycarbonate nanofibers: the effects of molecular motion and conformation in solutions. Eur Polym J 51:2887–2896
Liu SL, Long YZ, Zhang ZH, Zhang HD, Sun B, Zhang JC, Han WP (2013) Assembly of oriented ultrafine polymer fibers by centrifugal electrospinning. J Nanomater 2013, Article ID 713275
Edmondson D, Cooper A, Jana S, Wood D, Zhang M (2012) Centrifugal electrospinning of highly aligned polymer nanofibers over a large area. J Mater Chem 12:18646–18652
Dabirian F, Ravandi SAH, Pishevar AR, Abuzade RA (2011) A comparative study of jet formation and nanofiber alignment in electrospinning and electrocentrifugal spinning systems. J Electrostat 69:540–546
Kancheva M, Toncheva A, Manolova N, Rashkov I (2014) Advanced centrifugal electrospinning setup. Mater Lett 136:150–152
Sun D, Chang C, Li S, Lin L (2006) Near-field electrospinning. Nano Lett 6:839–842
Chang C, Limkrailassiri K, Lin L (2008) Continuous near-field electrospinning for large area deposition of orderly nanofiber patterns. Appl Phys Lett 93:123111
Bisht G, Nesterenko S, Kulinsky L, Madou M (2012) A Computer-controlled near-field electrospinning setup and its graphic user interface for precision patterning of functional nanofibers on 2D and 3D substrates. J Lab Autom 17:302–308
Zheng J, Long YZ, Sun B, Zhang ZH, Shao F, Zhang HD, Zhang ZM, Huang JY (2012) Polymer nanofibers prepared by low-voltage near-field electrospinning. Chin Phys B 21(4):048102
Chang C, Tran VH, Wang J, Fuh YK, Lin L (2010) Direct-write piezoelectric polymeric nanogenerator with high energy conversion efficiency. Nano Lett 10:726–731
Zhou FL, Hubbard PL, Eichhorn SJ, Parker GJM (2011) Jet deposition in near-field electrospinning of patterned polycaprolactone and sugar-polycaprolactone core–shell fibres. Polymer 52:3603–3610
Camillo DD, Fasano V, Ruggieri F, Santucci S, Lozzi L, Camposeo A, Pisignano D (2013) Near-field electrospinning of light-emitting conjugated polymer nanofibers. Nanoscale 5:11637–11642
Hellmann C, Belardi J, Dersch R, Greiner A, Wendorff JH, Bahnmueller S (2009) High precision deposition electrospinning of nanofibers and nanofiber nonwovens. Polymer 50:1197–1205
Zheng G, Li W, Wang X, Wu D, Sun D, Lin L (2010) Precision deposition of a nanofibre by near-field electrospinning. J Phys D Appl Phys 43:415501
Luo CJ, Stoyanov SD, Stride E, Pelan E, Edirisinghe M (2012) Electrospinning versus fibre production methods: from specifics to technological convergence. Chem Soc Rev 41:4708–4735
Kameoka J, Orth R, Yang Y, Czaplewski D, Mathers R, Coates GW, Craighead HG (2003) Scanning tip electrospinning source for deposition of oriented nanofibres. Nanotechnology 14:1124–1129
Fazley Elahi MD, Lu W, Guoping G, Khan F (2013) Core-shell fibers for biomedical applications—A review. J Bioeng Biomed Sci 3:1–14
Loscertales IG, Barrero A, Guerrero I, Cortijo R, Marquez M, Ganan-Calvo AM (2002) Micro/nano encapsulation via electrified coaxial liquid jets. Science 295:1695–1698
Amler E, Mickova A, Buzgo M (2013) Electrospun core/shell nanofibers: a promising system for cartilage and tissue engineering? Nanomedicine 8:509–512
Qu H, Wei S, Guo Z (2013) Coaxial electrospun nanostructures and their applications. J Mater Chem A 1:11513–11528
McCann JT, Li D, Xia YN (2005) Electrospinning of nanofibers with core-sheath, hollow, or porous structures. J Mater Chem 15:735–738
Anka FH, Balkus KJ (2013) Novel Nanofiltration hollow fiber membrane produced via electrospinning. Ind Eng Chem Res 52:3473–3480
Lee BS, Son SB, Park KM, Seo JH, Lee SH, Choi IS, Oh KH, Yu WR (2012) Fabrication of Si core/C shell nanofibers and their electrochemical performances as a lithium-ion battery anode. J Power Sources 206:267–273
Jiang G, Qin X (2014) An improved free surface electrospinning for high throughput manufacturing of core–shell nanofibers. Mater Lett 128:259–262
McCann JT, Marquez M, Xia Y (2006) Melt coaxial electrospinning: a versatile method for the encapsulation of solid materials and fabrication of phase change nanofibers. Nano Lett 6:2868–2872
Wang M, Jing N, Su CB, Kameoka J, Chou CK, Hung MC, Chang KA (2006) Electrospinning of silica nanochannels for single molecule detection. Appl Phys Lett 88:033106
Kalra V, Lee JH, Park JH, Marquez M, Joo YL (2009) Confined assembly of asymmetric block-copolymer nanofibers via multiaxial jet electrospinning. Small 5:2323–2332
Chen HY, Wang N, Di JC, Zhao Y, Song YL, Jiang L (2010) anowire-in-microtube structured Core/Shell fibers via multifluidic coaxial electrospinning. Langmuir 26:11291–11296
Han D, Steckl AJ (2013) Triaxial electrospun nanofiber membranes for controlled dual release of functional molecules. Interfaces 5:8241–8245
Srivastava Y, Loscertales I, Marquez M, Thorsen T (2008) Electrospinning of hollow and core/sheath nanofibers using a microfluidic manifold. Microfluid Nanofluid 4:245–250
Srivastava Y, Rhodes C, Marquez M, Thorsen T (2008) Electrospinning hollow and core/sheath nanofibers using hydrodynamic fluid focusing. Microfluid Nanofluid 5:455–458
Jiang H, Wang L, Zhu K (2014) Coaxial electrospinning for encapsulation and controlled release of fragile water-soluble bioactive agents. J Control Release 193:296–303
Wang C, Tong SN, Tse YH, Wang M (2012) Conventional electrospinning vs. emulsion electrospinning: a comparative study on the development of nanofibrous drug/biomolecule delivery vehicles. Adv Mater Res 410:118–121
Vasita R, Gelain F (2013) Core-sheath fibers for regenerative medicine. In: Tiwari A, Tiwari A (eds) Nanomaterials in drug delivery, imaging, and tissue engineering. Wiley, Hoboken, pp 493–534
Hua J, Prabhakaran MP, Ding X, Ramakrishna S (2015) Emulsion electrospinning of polycaprolactone: influence of surfactant type towards the scaffold properties. J Biomater Sci Polym Ed 26:57–75
Xu XL, Yang LX, Xu XY, Wang X, Chen XS, Liang QZ, Zeng J, Jing XB (2005) Ultrafine medicated fibers electrospun from W/O emulsions. J Control Release 108:33–42
Viry L, Moulton SE, Romeo T, Suhr C, Mawad D, Cook M, Wallace GG (2012) Emulsion-coaxial electrospinning: designing novel architectures for sustained release of highly soluble low molecular weight drugs. J Mater Chem 22:11347–11353
Wang C, Wang M (2014) Formation of core–shell structures in emulsion electrospun fibres: a comparative study. Aust J Chem 67:1403–1413
Angeles M, Cheng HL, Velankar SS (2008) Emulsion electrospinning: Composite fibers from drop breakup during electrospinning. Polym Adv Technol 19:728–733
Ingavle GC, Leach JK (2014) Advancements in electrospinning of polymeric nanofibrous scaffolds for tissue engineering. Tissue Eng Part B Rev 20:277–293
Sill TJ, von Recum HA (2008) Electrospinning: applications in drug delivery and tissue engineering. Biomaterials 29:1989–2006
Khan WS, Asmatulu R, Ceylan M, Jabbarnia A (2013) Recent progress on conventional and non-conventional electrospinning processes. Fiber Polym 14:1235–1247
Ki CS, Baek DH, Gang KD, Lee KH, Um IC, Park YH (2005) Characterization of gelatin nanofiber prepared from gelatin-formic acid solution. Polymer 46:5094–5102
Megelski S, Stephens JS, Chase DB, Rabolt JF (2002) Micro- and nanostructured surface morphology on electrospun polymer fibers. Macromolecules 35:8456–8466
Huang L, Nagapudi K, Apkarian RP, Chaikof EL (2001) Engineered collagen-PEO nanofibers and fabrics. J Biomater Sci Polym Ed 12:979–993
Haghi AK, Akbari M (2007) Trends in electrospinning of natural nanofibers. Phys Status Solidi 204:1830–1834
Andrady AL (2008) Factors affecting nanofiber quality. In: Science and technology of polymer nanofibers. Wiley, Hoboken, pp 81–110
Pelipenko J, Kristl J, Jankovic B, Baumgartner S, Kocbek P (2013) The impact of relative humidity during electrospinning on the morphology and mechanical properties of nanofibers. Int J Pharm 456:125–134
Okutan N, Terzi P, Altay F (2014) Affecting parameters on electrospinning process and characterization of electrospun gelatin nanofibers. Food Hydrocolloids 39:19–26
Liu Y, He JH, Yu JY, Zeng HM (2008) Controlling numbers and sizes of beads in electrospun nanofibers. Polym Int 57:632–636
Pham QP, Sharma U, Mikos AG (2006) Electrospinning of polymeric nanofibers for tissue engineering applications: a review. Tissue Eng 12:1197–1211
Zhang C, Yuan X, Wu L, Han Y, Sheng J (2005) Study on morphology of electrospun poly(vinyl alcohol) mats. Eur Polym J 41:423–432
Demir MM, Yilgor I, Yilgor E, Erman B (2002) Electrospinning of polyurethane fibres. Polymer 43:3303–3309
Reneker DH, Chun L (1996) Nanometre diameters of polymer produced by electrospinning. Nanotechnology 7:216–223
Geng X, Kwon K-H, Jang J (2005) Electrospinning of chitosan dissolved in concentrated acetic acid solution. Biomaterials 26:5427–5432
Katti DS, Robinson KW, Ko FK, Laurencin CT (2004) Bioresorbable nanofiber-based systems for wound healing and drug delivery: optimization of fabrication parameters. J Biomed Mater Res Part B Appl Biomater 70:286–296
Agarwal S, Greiner A, Wendorff JH (2013) Functional materials by electrospinning of polymers. Prog Polym Sci 38:963–991
Vrieze SD, Camp TV, Nelvig A, Hagstrom B, Westbroek P, Clerck KD (2009) The effect of temperature and humidity on electrospinning. J Mater Sci 44:1357–1362
Casper CL, Stephens JS, Tassi NG, Chase DB, Rabolt JF (2004) Controlling surface morphology of electrospun polystyrene fibers: effect of humidity and molecular weight in the electrospinning process. Macromolecules 37:573–578
Li D, Wang YL, Xia Y (2003) Electrospinning of polymeric and ceramic nanofibers as uniaxially aligned arrays. Nano Lett 3:1167–1171
Pagliara S, Camposeo A, Polini A, Cingolani R, Pisignano D (2009) Electrospun light-emitting nanofibers as excitation source in microfluidic devices. Lab Chip 9:2851–2856
Agarwal S, Greimer A, Wendorff JH (2009) Electrospinning of manmade and biopolymer nanofibers—Progress in techniques, materials, and applications. Adv Funct Mater 19:2863–2879
Matthews JA, Wnek GE, Simpson DG, Bowlin GL (2002) Electrospinning of collagen nanofibers. Biomacromolecules 3:232–238
Vaz CM, van Tuijl S, Bouten CVC, Baaijens FPT (2005) Design of scaffolds for blood vessel tissue engineering using a multi-layering electrospinning technique. Acta Biomater 1:575–582
Putti M, Simonet M, Solberg R, Peters GWM (2015) Electrospinning poly(ε-caprolactone) under controlled environmental conditions: influence on fiber morphology and orientation. Polymer 63:189–195
Chan KHK, Wong SY, Tiju WC, Li X, Kotaki M, He CB (2010) Morphologies and electrical properties of electrospun poly (R)-3- hydroxybutyrate-co-(R)-3-hydroxyvalerate/ multiwalled carbon nanotubes fibers. J Appl Polym Sci 116(2):1030–1035
Katta P, Alessandro M, Ramsier RD, Chase GG (2004) Continuous electrospinning of aligned polymer nanofibers onto a wire drum collector. Nano Lett 4:2215–2218
Sundaray B, Subramanian V, Natarajan TS, Xiang RZ, Chang CC, Fann WS (2004) Electrospinning of continuous aligned polymer fibers. Appl Phys Lett 84:1222–1224
Beachley V, Katsanevakis E, Zhang N, Wen X (2012) In: Jayakumar R, Nair S (eds) Biomedical applications of polymeric nanofibers, vol 246. Springer, Berlin, pp 171–212
Kiselev P, Rosell-Llompart J (2012) Highly aligned electrospun nanofibers by elimination of the whipping motion. J Appl Polym Sci 125:2433–2441
Theron A, Zussman E, Yarin AL (2001) Electrostatic field-assisted alignment of electrospun nanofibres. Nanotechnology 12:384–390
Park SH, Yang DY (2011) Fabrication of aligned electrospun nanofibers by inclined gap method. J Appl Polym Sci 120:1800–1807
Ramakrishna S, Fujihara K, Teo WE, Lim TC, Ma Z (2005) Electrospinning process. In: An introduction to electrospinning and nanofibers. World Scientific Publishing Company, Singapore, pp 90–154
Teo WE, Ramakrishna S (2006) A review on electrospinning design and nanofibre assemblies. Nanotechnology 17:R89–R106
Li D, Wang YL, Xia Y (2004) Electrospinning Nanofibers as uniaxially aligned arrays and layer-by-layer stacked films. Adv Mater 16:361–366
Teo WE, Ramakrishna S (2005) Electrospun fibre bundle made of aligned nanofibres over two fixed points. Nanotechnology 16:1878–1884
Kakade MV, Givens S, Gardner K, Lee KH, Chase DB, Rabolt JF (2007) Electric field induced orientation of polymer chains in macroscopically aligned electrospun polymer nanofibers. J Am Chem Soc 129:2777–2782
Pokorny M, Niedoba K, Velebny V (2010) Transversal electrostatic strength of patterned collector affecting alignment of electrospun nanofibers. Appl Phys Lett 96:193111
Bazbouz MB, Stylios GK (2008) Alignment and optimization of nylon 6 nanofibers by electrospinning. J Appl Polym Sci 107:3023–3032
Kim G, Kim W (2006) Formation of oriented nanofibers using electrospinning. Appl Phys Lett 88:233101
Dalton PD, Klee D, Moller M (2005) Electrospinning with dual collection rings. Polymer 46:611–614
Park SH, Hong JW, Shin JH, Yang DY (2011) Quantitatively controlled fabrication of uniaxially aligned nanofibrous scaffold for cell adhesion. J Nanomater, Article ID 201969
Teo WE, Kotaki M, Mo XM, Ramakrishna S (2005) Porous tubular structures with controlled fibre orientation using a modified electrospinning method. Nanotechnology 16:918–924
Carnell LS, Siochi EJ, Holloway NM, Stephens RM, Rhim C, Niklason LE, Clark RL (2008) Aligned mats from electrospun single fibers. Macromolecules 41:5345–5349
Zussman E, Theron A, Yarin AL (2003) Electrostatic field-assisted building 3-D nano-structures from electrospun nanofibers. Appl Phys Lett 82:973–975
Wu Y, Carnell LA, Clark RL (2007) Control of electrospun mat width through the use of parallel auxiliary electrodes. Polymer 48:5653–5661
Nurfaizey AH, Stanger J, Tucker N, Buunk N, Wallace A, Staiger MP (2012) Manipulation of electrospun fibres in flight: the principle of superposition of electric fields as a control method. J Mater Sci 47:1156–1163
Jafari A, Jeon JH, Oh IK (2011) Well-aligned nano-fiberous membranes based on three-pole electrospinning with channel electrode. Macromol Rapid Commun 32:921–926
Acharya M, Arumugam GK, Heiden PA (2008) Dual electric field induced alignment of electrospun nanofibers. Macromol Mater Eng 293:666–674
Arras MML, Grasl C, Bergmeister H, Schima H (2012) Electrospinning of aligned fibers with adjustable orientation using auxiliary electrodes. Sci Technol Adv Mater 13:035008
Grasl C, Arras MML, Stoiber M, Bergmeister H, Schima H (2013) Electrodynamic control of the nanofiber alignment during electrospinning. Appl Phys Lett 102:053111
dos Santos AM, Dierck J, Troch M, Podevijn M, Schach E (2011) Production of continuous electrospun mats with improved mechanical properties. Macromol Mater Eng 296:637–644
Unser AM, Xie Y (2012) Electrospinning of nanofibers. In: Xie Y (ed) The nanobiotechnology handbook. CRC Press, Boca Raton, pp 293–320
Shin EH, Cho KS, Seo MH, Kim H (2008) Determination of electrospun fiber diameter distributions using image analysis processing. Macromol Res 16:314–319
Chen JP, Su CH (2011) Surface modification of electrospun PLLA nanofibers by plasma treatment and cationized gelatin immobilization for cartilage tissue engineering. Acta Biomater 7:234–243
Haghi AK, Zaikov GE (2010) Nanofiber research: advances in theory and practice. Nova Science Publishers. Inc, New York, pp 59–106
Ziabari M, Mottaghitalab V, Haghi AK (2009) Application of direct tracking method for measuring electrospun nanofiber diameter. Braz J Chem Eng 26:53–62
Öznergiz E, Kiyak YE, Kamasak ME, Yildirim I (2014) Automated nanofiber diameter measurement in SEM images using a robust image analysis method. J Nanomater 2014, Article ID 738490
Barhate RS, Loong CK, Ramakrishna S (2006) Preparation and characterization of nanofibrous filtering media. J Membr Sci 283:209–218
Aussawasathien D, Teerawattananon C, Vongachariya A (2008) Separation of micron to sub-micron particles from water: electrospun nylon-6 nanofibrous membranes as pre-filters. J Membr Sci 315:11–19
Affandi NDN, Truong YB, Kyratzis IL, Padhye R, Arnold L (2010) A non-destructive method for thickness measurement of thin electrospun membranes using white light profilometry. J Mater Sci 45:1411–1418
Rutledge GC, Lowery JL, Chia-Ling P (2009) Characterization by mercury porosimetry of nonwoven fiber media with deformation. J Eng Fiber Fabr 4:1–13
Frey MW, Li L (2007) Electrospinning and porosity measurements of nylon-6/poly(ethylene oxide) blended nonwovens. J Eng Fiber Fabr 2:31–37
Ziabari M, Mottaghitalab V, Khodaparast Haghi A (2008) Evaluation of electrospun nanofiber pore structure parameters. Korean J Chem Eng 25:923–932
Ghasemi-Mobarakeh L, Semnani D, Morshed M (2007) A novel method for porosity measurement of various surface layers of nanofibers mat using image analysis for tissue engineering applications. J Appl Polym Sci 106:2536–2542
Sreedhara SS, Tata NR (2013) Novel method for measurement of porosity in nanofiber mat using pycnometer in filtration. J Eng Fiber Fabr 8:132–137
Tan EPS, Lim CT (2006) Mechanical characterization of nanofibers—A review. Compos Sci Technol 66:1102–1111
Bazbouz MB, Stylios GK (2010) The tensile properties of electrospun nylon 6 single nanofibers. J Polym Sci 48:1719–1731
Hang F, Lu D, Bailey RJ, Jimenez-Palomar I, Stachewicz U, Cortes-Ballesteros B, Davies M, Zech M, Bodefeld C, Barber AH (2011) In situ tensile testing of nanofibers by combining atomic force microscopy and scanning electron microscopy. Nanotechnology 22:365708
Mohammadzadehmoghadam S, Dong Y, Daives IJ (2015) Recent progress in electrospun nanofibers: reinforcement effect and mechanical performance. J Polym Sci Pt B-Polym Phys 53:1171–1212
Zussman E, Burman M, Yarin AL, Khalfin R, Cohen Y (2006) Tensile deformation of electrospun nylon-6,6 nanofibers. J Polym Sci Part B Polym Phys 44:1482–1489
Li Y, Lim CT, Kotaki M (2015) Study on structural and mechanical properties of porous PLA nanofibers electrospun by channel-based electrospinning system. Polymer 56:572–580
Tan EPS, Ng SY, Lim CT (2005) Tensile testing of a single ultrafine polymeric fiber. Biomaterials 26:1453–1456
Papkov D, Zou Y, Andalib MN, Goponenko A, Cheng SZD, Dzenis YA (2013) Simultaneously strong and tough ultrafine continuous nanofibers. ACS Nano 7:3324–3331
Fee TJ, Dean DR, Eberhardt AW, Berry JL (2012) A novel device to quantify the mechanical properties of electrospun nanofibers. J Biomech Eng 134:104503
Naraghi M, Chasiotis I, Kahn H, Wen Y, Dzenis Y (2007) Mechanical deformation and failure of electrospun polyacrylonitrile nanofibers as a function of strain rate. Appl Phys Lett 91:151901
Jaeger D, Schischka J, Bagdahn J, Jaeger R (2009) Tensile testing of individual ultrathin electrospun poly(L-lactic acid) fibers. J Appl Polym Sci 114:3774–3779
Carlisle CR, Coulais C, Namboothiry M, Carroll DL, Hantgan RR, Guthold M (2009) The mechanical properties of individual, electrospun fibrinogen fibers. Biomaterials 30:1205–1213
Baker S, Sigley J, Helms CC, Stitzel J, Berry J, Bonin K, Guthold M (2012) The mechanical properties of dry, electrospun fibrinogen fibers. Mater Sci Eng C 32:215–221
Gestos A, Whitten PG, Spinks GM, Wallace GG (2013) Tensile testing of individual glassy, rubbery and hydrogel electrospun polymer nanofibres to high strain using the atomic force microscope. Polym Test 32:655–664
Tan EPS, Lim CT (2004) Physical properties of a single polymeric nanofiber. Appl Phys Lett 84:1603–1605
Liao CC, Wang CC, Chen CY, Lai WJ (2011) Stretching-induced orientation of polyacrylonitrile nanofibers by an electrically rotating viscoelastic jet for improving the mechanical properties. Polymer 52:2263–2275
Bellan LM, Kameoka J, Craighead HG (2005) Measurement of the Young’s moduli of individual polyethylene oxide and glass nanofibres. Nanotechnology 16:1095–1099
Gu SY, Wu QL, Ren J, Vancso GJ (2005) Mechanical properties of a single electrospun fiber and its structures. Macromol Rapid Commun 26:716–720
Guhados G, Wan W, Hutter JL (2005) Measurement of the elastic modulus of single bacterial cellulose fibers using atomic force microscopy. Langmuir 21:6642–6646
Croisier F, Duwez AS, Jérôme C, Léonard AF, van der Werf KO, Dijkstra PJ, Bennink ML (2012) Mechanical testing of electrospun PCL fibers. Acta Biomater 8:218–224
Zussman E, Chen X, Ding W, Calabri L, Dikin DA, Quintana JP, Ruoff RS (2005) Mechanical and structural characterization of electrospun PAN-derived carbon nanofibers. Carbon 43:2175–2185
Yuya PA, Wen Y, Turner JA, Dzenis YA, Li Z (2007) Determination of the Young’s modulus of individual electrospun nanofibers by microcantilever vibration method. Appl Phys Lett 90:111909
Liu Y, Chen S, Zussman E, Korach CS, Zhao W, Rafailovich M (2011) Diameter-dependent modulus and melting behavior in electrospun semicrystalline polymer fibers. Macromolecules 44:4439–4444
Burman M, Arinstein A, Zussman E (2008) Free flight of an oscillated string pendulum as a tool for the mechanical characterization of an individual polymer nanofiber. Appl Phys Lett 93:193118
Wang W, Peijs T, Barber AH (2010) Indentation induced solid state ordering of electrospun polyethylene oxide fibres. Nanotechnology 21:035705
Chen YQ, Zheng XJ, Mao SX, Li W (2010) Nanoscale mechanical behavior of vanadium doped ZnO piezoelectric nanofiber by nanoindentation technique. J Appl Phys 107:094302
Ji Y, Li B, Ge S, Sokolov JC, Rafailovich MH (2006) Structure and nanomechanical characterization of electrospun PS/clay nanocomposite fibers. Langmuir 22:1321–1328
Lin Y, Clark DM, Yu X, Zhong Z, Liu K, Reneker DH (2012) Mechanical properties of polymer nanofibers revealed by interaction with streams of air. Polymer 53:782–790
Hwang KY, Kim SD, Kim YW, Yu WR (2010) Mechanical characterization of nanofibers using a nanomanipulator and atomic force microscope cantilever in a scanning electron microscope. Polym Test 29:375–380
Wong SC, Baji A, Leng S (2008) Effect of fiber diameter on tensile properties of electrospun poly (ɛ-caprolactone). Polymer 49:4713–4722
Shin MK, Kim SI, Kim SJ, Kim SK, Lee H, Spinks GM (2006) Size-dependent elastic modulus of single electroactive polymer nanofibers. Appl Phys Lett 89:231929
Arinstein A, Burman M, Gendelman O, Zussman E (2007) Effect of supramolecular structure on polymer nanofibre elasticity. Nat Nanotechnol 2:59–62
Wu XF, Dzenis YA (2007) Size effect in polymer nanofibers under tension. J Appl Phys 102:044306
Camposeo A, Greenfeld I, Tantussi F, Pagliara S, Moffa M, Fuso F, Allegrini M, Zussman E, Pisignano D (2013) Local mechanical properties of electrospun fibers correlate to their internal nanostructure. Nano Lett 13:5056–5062
Arinstein A (2013) Confinement mechanism of electrospun polymer nanofiber reinforcement. J Polym SciPart B Polym Phys 51:756–763
Naraghi M, Chasiotis I, Kahn H, Wen Y, Dzenis Y (2007) Novel method for mechanical characterization of polymeric nanofibers. Rev Sci Instrum 78:085108
Wu XF, Zhou Z, Rahman A, Bedarkar A (2013) Mechanical properties of continuous nanofibers: characterization and mechanics. In: Dong Y (ed) Nanostructures: properties, production methods and applications. Nova Science Publishers Inc, New York, pp 247–286
Tan EPS, Zhang YZ, Ramakrishna S, Teck LC (2007) Polymer nanofibers: fabrication, applications and characterization. In: Mohammad F (ed) Specialty polymers: materials and applications. I. K. International Pvt Ltd, New Delhi, pp 77–116
Rahman Khan MM, Tsukada M, Zhang XH, Morikawa H (2013) Preparation and characterization of electrospun nanofibers based on silk sericin powders. J Mater Sci 48:3731–3736
Lespade P, Marchand A, Couzi M, Cruege MF (1984) Caracterisation de materiaux carbones par microspectrometrie Raman. Carbon 22:375–385
Sadrjahani M, Hoseini SA, Mottaghitalab V, Haghi AK (2010) Development and characterization of highly oriented pan nanofiber. Braz J Chem Eng 27:583–589
Kim SH, Nam YS, Lee TS, Park WH (2003) Silk Fibroin Nanofiber. Electrospinning Prop Struct Polym J 35:185–190
Ratner BD, Chilkoti A, Castner DG (1992) Contemporary methods for characterizing complex biomaterial surfaces. Clin Mater 11:25–36
Zhang Y, Huang ZM, Xu X, Lim CT, Ramakrishna S (2004) Preparation of core-shell structured PCL-r-gelatin bi-component nanofibers by coaxial electrospinning. Chem Mater 16:3406–3409
Abbasi A, Nasef MM, Takeshi M, Faridi-Maj R (2014) Electrospinning of nylon-6,6 solutions into nanofibers: rheology and morphology relationships. Chin J Polym Sci 32:793–804
Peresin MS, Habibi Y, Zoppe JO, Pawlak JJ, Rojas OJ (2010) Nanofiber composites of polyvinyl alcohol and cellulose nanocrystals: manufacture and characterization. Biomacromolecules 11:674–681
Ero-Phillips O, Jenkins M, Stamboulis A (2012) Tailoring Crystallinity of electrospun PLLA fibres by control of electrospinning parameters. Polymers 4:1331–1348
Cui WG, Li XH, Zhu XL, Yu G, Zhou SB, Weng J (2006) Investigation of drug release and matrix degradation of electrospun poly(DL-lactide) fibers with paracetanol inoculation. Biomacromolecules 7:1623–1629
Zong XH, Ran SF, Kim KS, Fang DF, Hsiao BS, Chu B (2003) Structure and morphology changes during in vitro degradation of electrospun poly(glycolide-co-lactide) nanofiber membrane. Biomacromolecules 4:416–423
Luzio A, Canesi EV, Bertarelli C, Caironi M (2014) Electrospun polymer fibers for electronic applications. Materials 7:906–947
Prabhakaran MP, Ghasemi-Mobarakeh L, Jin G, Ramakrishna S (2011) Electrospun conducting polymer nanofibers and electrical stimulation of nerve stem cells. J Biosc Bioeng 112:501–507
Chronakis IS, Grapenson S, Jakob A (2006) Conductive polypyrrole nanofibers via electrospinning: electrical and morphological properties. Polymer 47:1597–1603
Agend F, Naderi N, Fareghi-Alamdari R (2007) Fabrication and electrical characterization of electrospun polyacrylonitrile-derived carbon nanofibers. J Appl Polym Sci 106:255–259
Srivastava Y, Marquez M, Thorsen T (2007) Multijet electrospinning of conducting nanofibers from microfluidic manifolds. J Appl Polym Sci 106:3171–3178
Zhang Y (2013) Electrospun nanofibers with tunable electrical conductivity. Ph.D dissertation, Massachusetts Institute of Technology, USA
Zhang Y, Rutledge GC (2012) Electrical conductivity of electrospun polyaniline and polyaniline-blend fibers and mats. Macromolecules 45:4238–4246
McCullen SD, Stevens DR, Roberts WA, Ojha SS, Clarke LI, Gorga RE (2007) Morphological, electrical, and mechanical characterization of electrospun nanofiber mats containing multiwalled carbon nanotubes. Macromolecules 40:997–1003
MacDiarmid AG, Jones WE Jr, Norris ID, Gao J, Johnson AT Jr, Pinto NJ, Hone J, Han B, Ko FK, Okuzaki H, Llaguno M (2001) Electrostatically-generated nanofibers of electronic polymers. Synth Met 119:27–30
Nagata S, Atkinson GM, Pestov D, Tepper GC, Mcleskey Jr JT (2013) Electrospun polymer-fiber solar cell. Adv Mater Sci Eng 2013, Article ID 975947
Babel A, Li D, Xia Y, Jenekhe SA (2005) Electrospun nanofibers of blends of conjugated polymers: morphology, optical properties, and field-effect transistors. Macromolecules 38:4705–4711
Balderas U, Falcony C, Moggio I, Ariasc E, Mondragón M (2013) A photoluminescence study of electrospun fibers of conjugated poly[2-methoxy-5-(2-ethylhexyloxy)-1,4-phenylenevinylene] blended with poly(9-vinylcarbazole). Polymer 54:2062–2066
Kumar A, Jose R, Fujihara K, Wang J, Ramakrishna S (2007) Structural and optical properties of electrospun TiO2 nanofibers. Chem Mater 19:6536–6542
Kim JS, Reneker DH (1999) Mechanical properties of composites using ultrafine electrospun fibers. Polym Compos 20:124–131
Tang C, Liu H (2008) Cellulose nanofiber reinforced poly (vinyl alcohol) composite film with high visible light transmittance. Compos Part A-Appl S 39:1638–1643
Lu B, Zheng G, Dai K, Liu C, Chen J, Shen C (2015) Enhanced mechanical properties ofpolyethylene composites with low content of electrospun nylon-66 nanofibers. Mater Lett 140:131–134
Sun W, Cai Q, Li P, Deng X, Wei Y, Xu M, Yang X (2010) Post-draw PAN-PMMA nanofiber reinforced and toughened bis-GMA dental restorative composite. Dent Mater 26:873–880
Liao H, Wu Y, Wu M, Zhan X, Liu H (2012) Aligned electrospun cellulose fibers reinforced epoxy resin composite films with high visible light transmittance. Cellulose 19:111–119
Tang C, Wu M, Wu Y, Liu H (2011) Effects of fiber surface chemistry and size on the structure and properties of poly(vinyl alcohol) composite films reinforced with electrospun fibers. Compos Part A Appl S 42:1100–1109
Jiang S, Duan G, Schöbel J, Agarwal S, Greiner A (2013) Short electrospun polymeric nanofibers reinforced polyimide nanocomposites. Compos Sci Technol 88:57–61
Wu M, Wu Y, Liu Z, Liu H (2012) Optically transparent poly(methyl methacrylate) composite films reinforced with electrospun polyacrylonitrile nanofibers. J Compos Mater 46:2731–2738
Meng F, Zhao R, Zhan Y, X Liu X (2011) Design of thorn-like micro/nanofibers: fabrication and controlled morphology for engineered composite materials applications. J Mater Chem 21:16385–16390
Liao H, Wu Y, Wu M, Liu H (2011) Effects of fiber surface chemistry and roughness on interfacial structures of electrospun fiber reinforced epoxy composite films. Polym Compos 32:837–845
Dzenis Y (2008) Structural nanocomposites. Science 319:419–420
Magniez K, Chaffraix T, Fox B (2011) Toughening of a carbon-fibre composite using electrospun poly (hydroxyether of bisphenol a) nanofibrous membranes through inverse phase separation and inter-domain etherification. Materials 4:1967–1984
Zhang J, Yang T, Lin T, Wang CH (2012) Phase morphology of nanofibre interlayers: critical factor for toughening carbon/epoxy composites. Compos Sci Technol 72:256–262
Zhang J, Lin T, Wang X (2010) Electrospun nanofiber toughened carbon/epoxy composites: effects of polyetherketone cardo (PEK-C) nanofibre diameter and interlayer thickness. Compos Sci Technol 70:1660–1666
van der Heijden S, Daelemans L, Schoenmaker BD, Baere ID, Rahier H, Paepegem WV, Clerck KD (2014) Interlaminar toughening of resin transfer moulded glass fibre epoxy laminates by polycaprolactone electrospun nanofibres. Compos Sci Technol 104:66–73
Langer R, Vacanti J (1993) Tissue engineering. Science 260:920–926
Cen L, Liu W, Cui L, Zhang W, Cao Y (2008) Collagen tissue engineering: Development of novel biomaterials and applications. Pediatr Res 63:492–496
Dvir T, Timko BP, Kohane DS, Langer R (2011) Nanotechnological strategies for engineering complex tissues. Nat Nanotechnol 6:13–22
Ribba L, Parisi M, D’Accorso NB, Goyanes S (2014) Electrospun nanofibrous mats: from vascular repair to osteointegration. J Biomed Nanotechnol 10:1–28
Pelipenko J, Kocbek P, Kristl J (2015) Nanofiber diameter as a critical parameter affecting skin cell response. Eur J Pharm Sci 66:29–35
Doustgani A, Vheghani-Farahani E, Soleimani M (2013) Aligned and random nanofibrous nanocomposite scaffolds for bone tissue. Nanomed J 1:20–27
Gomes SR, Rodrigues G, Martins GG, Roberto MA, Mafra M, Henriques CMR, Silva JC (2015) In vitro and in vivo evaluation of electrospun nanofibers of PCL, chitosan and gelatin: a comparative study. Mater Sci Eng C Mater Biol Appl 46:348–358
Gluck JM, Rahgozar P, Ingle NP, Rofail F, Petrosian A, Cline MG, Jordan MC, Roos KP, MacLellan WR, Shemin RJ, Heydarkhan-Hagvall S (2011) Hybrid coaxial electrospun nanofibrous scaffolds with limited immunological response created for tissue engineering. J Biomed Mater Res B 99B:180–190
Kim YT, Haftel VK, Kumar S, Bellamkonda RV (2008) The role of aligned polymer fiber-based constructs in the bridging of long peripheral nerve gaps. Biomaterials 9:3117–3127
Shalumon KT, Anulekha KH, Chennazhi KP, Tamura H, Nair SV, Jayakumar R (2011) Fabrication of chitosan/poly (caprolactone) nanofibrous scaffold for bone and skin tissue engineering. Int J Biol Macromol 48:571–576
Pillay V, Dott C, Choonara YE, Tyagi C, Toma L, Kumar P, du Toit LC, Ndesendo VMK (2013) A review of the effect of processing variables on the fabrication of electrospun nanofibers for drug delivery applications. J Nanomater 2013, Article ID 789289
Gilchrist SE, Lange D, Letchford K, Bach H, Fazli L, Burt HM (2013) Fusidic acid and rifampicin co-loaded PLGA nanofibers for the prevention of orthopedic implant associated infections. J Control Release 170:64–73
Lu T, Jing X, Song X, Wang X (2012) Doxorubicin-loaded ultrafine PEG-PLA fiber mats against hepatocarcinoma. J Appl Polym Sci 123:209–217
Tungprapa S, Jangchud I, Supaphol P (2007) Release characteristics of four model drugs from drug-loaded electrospun cellulose acetate fiber mats. Polymer 48:5030–5041
Li X, Su Y, Liu S, Tan L, Mo X, Ramakrishna S (2010) Encapsulation of proteins in poly(L lactide- co-caprolactone) fibers by emulsion electrospinning. Colloid Surf B 75:418–424
De Laporte L, Shea LD (2007) Matrices and scaffolds for DNA delivery in tissue engineering. Adv Drug Deliv Rev 59:292–307
Rujitanaroj P, Wang YC, Wang J, Chew SY (2011) Nanofiber-mediated controlled release of siRNA complexes for long term gene-silencing applications. Biomaterials 32:5915–5923
Xu X, Chen X, Ma P, Wang X, Jing X (2008) The release behavior of doxorubicin hydrochloride from medicated fibers prepared by emulsion-electrospinning. Eur J Pharm Biopharm 70:165–170
Ranganath SH, Wang CH (2008) Biodegradable microfiber implants delivering paclitaxel for post-surgical chemotherapy against malignant glioma. Biomaterials 29:2996–3003
Kenawy ER, Abdel-Hay FI, El-Newehy MH, Wnek GE (2009) Processing of polymer nanofibers through electrospinning as drug delivery systems. Mater Chem Phys 113:296–302
Lin X, Tang D, Du H (2013) Self-assembly and controlled release behaviour of the water-insoluble drug nifedipine from electrospun PCL-based polyurethane nanofibres. J Pharm Pharmacol 65:673–681
Zamani M, Morshed M, Varshosaz J, Jannesari M (2010) Controlled release of metronidazole benzoate from poly epsilon-caprolactone electrospun nanofibers for periodontal diseases. Eur J Pharm Biopharm 75:179–185
Wang C, Yan KW, Lin YD, Hsieh PCH (2010) Biodegradable core/shell fibers by coaxial electrospinning: processing, fiber characterization, and its application in sustained drug release. Macromolecules 43:6389–6397
Meng ZX, Xu XX, Zheng W, Zhou HM, Lia L, Zheng YF, Lou X (2011) Preparation and characterization of electrospun PLGA/gelatin nanofibers as a potential drug delivery system. Colloids Surf B Biointerfaces 84:97–102
Liu C, Hsu PC, Lee HW, Ye M, Zheng G, Liu N, Li W, Cui Y (2015) Transparent air filter for high-efficiency PM2.5 capture. Nat Commun 6, Article number: 6205
Molaeipour Y, Gharehaghaji AA, Bahrami H (2014) Filtration performance of cigarette filter tip containing electrospun nanofibrous filter. J Indus Text. doi:10.1177/1528083714528016
Li J, Gao F, Liu LQ (2013) Zhang Z. Needleless electro-spun nanofibers used for filtration of small particles, eXPRESS Polym Lett 7:683–689
Jaroszczyk T, Petrik S, Donahue K (2009) Recent development in heavy duty engine air filtration and the role of nanofiber filter media. J KONES 16:207–216
Sang Y, Li F, Gu Q, Liang C, Chen J (2008) Heavy metal-contaminated groundwater treatment by a novel nanofiber membrane. Desalination 223:349–360
Daels N, De Vrieze S, Sampers I, Decostere B, Westbroek P, Dumoulin A, Dejans P, De Clerck K, Van Hulle SWH (2011) Potential of a functionalised nanofibre microfiltration membrane as an antibacterial water filter. Desalination 275:285–290
Wang XF, Chen XM, Yoon K, Fang DF, Hsiao BS, Chu B (2005) High flux filtration medium Based on nanofibrous substrate with hydrophilic nanocomposite coating. Environ Sci Technol 39:7684–7691
Ahmed FE, Lalia BS, Hashaikeh R (2015) A review on electrospinning for membrane fabrication: challenges and applications. Desalination 356:15–30
Wang X, Li Y, Ding B (2014) Electrospun nanofiber-Based sensors. In: Ding B, Yu J (eds) Electrospun nanofibers for energy and environmental applications. Springer, Berlin, pp 267–297
Khoshaman AH (2011) Application of electrospun thin films for supra-molecule based gas sensing. Master of applied sciences thesis, Simon Fraser University
Lin Q, Li Y, Yang M (2012) Highly sensitive and ultrafast response surface acoustic wave humidity sensor based on electrospun polyaniline/poly(vinyl butyral) nanofibers. Anal Chim Acta 748:73–80
Adewuyi S, Ondigo DA, Zugle R, Tshentu Z, Nyokong T, Torto N (2012) A highly selective and sensitive pyridylazo-2-naphthol-poly(acrylic acid) functionalized electrospun nanofiber fluorescence “turn-off” chemosensory system for Ni2+. Anal Method 4:1729–1735
Poltue T, Rangkupan R, Dubas ST, Dubas L (2011) Nickel (II) ions sensing properties of dimethylglyoxime/poly(caprolactone) electrospun fibers. Mater Lett 65:2231–2234
Li D, Pang Z, Chen X, Luo L, Cai Y, Wei Q (2014) A catechol biosensor based on electrospun carbon nanofibers. Beilstein J Nanotechnol 5:346–354
Nurfaizy AH, Tucker N, Stanger J, Staiger MP (2012) Functional nanofbers in clothing for protection against chemical and biological hazards. In: Wei Q (ed) Functional nanofibers and their applications. Woodhead Publishing, Cambridge, pp 236–261
Ko FK, Wan Y (2014) Nanofiber technology. In: Introduction to nanofiber materials. Cambridge University Press, Cambridge, pp 44–63
Gibson P, Schreuder-Gibson H, Rivin D (2001) Transport properties of porous membranes based on electrospun nanofibers. Colloids Surf A Physicochem Eng Asp 187:469–481
Schreuder-Gibson H, Gibson P, Senecal K, Sennett M, Walker J, Yeomans W, Ziegler D, Tsai PP (2002) Protective textile materials based on electrospun nanofibers. J Adv Mater 34(3):44–55
Lee S, Obendorf SK (2007) Use of Electrospun nanofiber web for protective textile materials as barriers to liquid penetration. Text Res J 77:696–702
Faccini M, Vaquero C, Amantia D (2012) Development of protective clothing against nanoparticle based on electrospun nanofibers. J Nanomater 2012, Article ID 892894
Vitchuli N, Shi Q, Nowak J, McCord M, Bourham M, Zhang X (2010) Electrospun ultrathin nylon fibers for protective applications. J Appl Polym Sci 116:2181–2187
Taepaiboon P, Rungsardthong U, Supaphol P (2007) Vitamin-loaded electrospun cellulose acetate nanofiber mats as transdermal and dermal therapeutic agents of vitamin A acid and vitamin E. Eur J Pharm Biopharm 67:387–397
Camerlo A, Corinne VN, Rossi RM, Popa AM (2013) Fragrance encapsulation in polymeric matrices by emulsion electrospinning. Eur Polym J 49:3806–3813
Fathi-Azarbayjani A, Qun L, Chan YW, Cha SY (2010) Novel vitamin and gold-loaded nanofiber facial mask for topical delivery. AAPS Pharm Sci Tech 11:1164–1170
Sheng X, Fan L, He C, Zhang K, Mo X, Wang H (2013) Vitamin E-loaded silk fibroin nanofibrous mats fabricated by green process for skin care application. Int J Biol Macromol 56:49–56
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Mohammadzadehmoghadam, S. et al. (2016). Electrospinning: Current Status and Future Trends. In: Fakirov, S. (eds) Nano-size Polymers. Springer, Cham. https://doi.org/10.1007/978-3-319-39715-3_4
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