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EBV and Autoimmunity

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Epstein Barr Virus Volume 1

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 390))

Abstract

Although a role of EBV in autoimmunity is biologically plausible and evidence of altered immune responses to EBV is abundant in several autoimmune diseases, inference on causality requires the determination that disease risk is higher in individuals infected with EBV than in those uninfected and that in the latter it increases following EBV infection. This determination has so far been possible only for multiple sclerosis (MS) and, to some extent, for systemic lupus erythematosus (SLE), whereas evidence is either lacking or not supportive for other autoimmune conditions. In this chapter, we present the main epidemiological findings that justify the conclusion that EBV is a component cause of MS and SLE and possible mechanisms underlying these effects.

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Abbreviations

CMV:

Cytomegalovirus

CNS:

Central nervous system

CSF:

Cerebrospinal fluid

DoDSR:

Department of defense serum repository

EBERs:

Epstein–Barr virus-encoded small RNAs

EBNA:

Epstein–Barr virus nuclear antigen

EBV:

Epstein–Barr virus

HLA:

Human leukocyte antigen

IM:

Infectious mononucleosis

MS:

Multiple sclerosis

OR:

Odds ratio

SLE:

Systemic lupus erythematosus

VCA:

Epstein–Barr virus viral capsid antigen

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Authors and Affiliations

  1. Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital, Boston, MA, USA

    Alberto Ascherio

  2. Harvard Medical School, Boston, MA, USA

    Alberto Ascherio

  3. Department of Epidemiology and Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA

    Alberto Ascherio & Kassandra L. Munger

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  1. Alberto Ascherio
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  2. Kassandra L. Munger
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Correspondence to Alberto Ascherio .

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Editors and Affiliations

  1. Institute of Experimental Immunology, University of Zürich, Zürich, Switzerland

    Christian Münz

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Ascherio, A., Munger, K.L. (2015). EBV and Autoimmunity. In: Münz, C. (eds) Epstein Barr Virus Volume 1. Current Topics in Microbiology and Immunology, vol 390. Springer, Cham. https://doi.org/10.1007/978-3-319-22822-8_15

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