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Cancer Stem Cells and Tumor Radioresistance

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Cancer Stem Cells: Emerging Concepts and Future Perspectives in Translational Oncology

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Abstract

Cancer stem cells (CSCs) in a variety of tumor types have intrinsically greater resistance to ionizing radiation (IR) than the remaining cancer cells. Since surviving CSCs have the capacity to regenerate tumor deposits, CSC radioresistance represents an important clinical problem. Here we discuss mechanisms that CSCs employ to resist IR and therapeutic strategies that are currently being used in the clinic or are in various stages of development for overcoming these. While much ongoing work shows promise for increasing the efficacy of IR through rational targeting of CSCs, well-designed clinical trials testing such strategies will be required to bring these approaches into the clinic.

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Authors and Affiliations

  1. Department of Radiation Oncology, Stanford University, Stanford, CA, USA

    Aadel A. Chaudhuri, Michael S. Binkley & Maximilian Diehn

  2. Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, CA, USA

    Maximilian Diehn

  3. Stanford Cancer Institute, Stanford University, Stanford, CA, USA

    Maximilian Diehn

Authors
  1. Aadel A. Chaudhuri
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  2. Michael S. Binkley
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  3. Maximilian Diehn
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Correspondence to Maximilian Diehn .

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Editors and Affiliations

  1. Faculty of Biol. Scs. Dept. of Mol. Gen., Tarbiat Modares University , Tehran, Iran

    Sadegh Babashah

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Chaudhuri, A.A., Binkley, M.S., Diehn, M. (2015). Cancer Stem Cells and Tumor Radioresistance. In: Babashah, S. (eds) Cancer Stem Cells: Emerging Concepts and Future Perspectives in Translational Oncology. Springer, Cham. https://doi.org/10.1007/978-3-319-21030-8_18

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