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Reversible and Irreversible Damage of the Myocardium: Ischemia/Reperfusion Injury and Cardioprotection

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Handbook of Cardiac Anatomy, Physiology, and Devices

Abstract

Ischemia and reperfusion injuries can lead to major compromises in cardiac function. While the intent of many of the past cardioprotective therapies was to protect the myocardium from ischemic necrosis, it may be that reperfusion injury following ischemia may occur despite such preventative attempts. There are continued efforts to identify improvements in myocardial protective strategies (pre- and postconditioning), and their ultimate goals are to minimize the risk of cellular injuries to all types of patients undergoing cardiovascular therapies, treatments, or surgeries.

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Authors and Affiliations

  1. University of Minnesota, 420 Delaware St. SE, B172 Mayo, MMC 195, Minneapolis, MN, 55455, USA

    Brian T. Howard PhD & Tinen L. Iles MS

  2. Medtronic, Inc., Minneapolis, MN, USA

    James A. Coles Jr. PhD

  3. Department of Surgery, University of Minnesota, Minneapolis, MN, USA

    Daniel C. Sigg MD, PhD & Paul A. Iaizzo PhD

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  1. Brian T. Howard PhD
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  2. Tinen L. Iles MS
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  3. James A. Coles Jr. PhD
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  4. Daniel C. Sigg MD, PhD
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  5. Paul A. Iaizzo PhD
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Correspondence to Tinen L. Iles MS .

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  1. B172 Mayo, MMC 195, University of Minnesota Department of Surgery, Minneapolis, Minnesota, USA

    Paul A. Iaizzo

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Howard, B.T., Iles, T.L., Coles, J.A., Sigg, D.C., Iaizzo, P.A. (2015). Reversible and Irreversible Damage of the Myocardium: Ischemia/Reperfusion Injury and Cardioprotection. In: Iaizzo, P. (eds) Handbook of Cardiac Anatomy, Physiology, and Devices. Springer, Cham. https://doi.org/10.1007/978-3-319-19464-6_16

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