Abstract
Astrocyte endfeet envelop the cerebral capillaries that form the blood-brain barrier. Swelling of these endfeet occurs early in cerebral ischemia. It is generally hypothesized that such swelling occurs as the result of factors released from parenchymal brain cells during an ischemic stroke (e.g., K+ and L-glutamate). In this review of mechanisms that can elicit astrocyte swelling in ischemic stroke, we hypothesize that, instead or in addition, such swelling may be a response to blood-brain barrier dysfunction. Astrocyte endfeet swelling may help form a cuff around a damaged vessel that limits the egress of plasma constituents and blood (hemorrhage) into brain.
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Acknowledgments
This work was supported by the National Institutes of Health grants NS034709, NS079639, and HL55374. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH.
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Xiang, J., Tang, Y., Li, C., Su, E.J., Lawrence, D.A., Keep, R.F. (2016). Mechanisms Underlying Astrocyte Endfeet Swelling in Stroke. In: Applegate, R., Chen, G., Feng, H., Zhang, J. (eds) Brain Edema XVI. Acta Neurochirurgica Supplement, vol 121. Springer, Cham. https://doi.org/10.1007/978-3-319-18497-5_4
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