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Understanding Cone Photoreceptor Cell Death in Achromatopsia

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Retinal Degenerative Diseases

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 854))

Abstract

Colour vision is only achieved in the presence of healthy and functional cone photoreceptors found in the retina. It is an essential component of human vision and usually the first complaint patients undergoing vision degeneration have is the loss of daylight colour vision. Therefore, an understanding of the biology and basic mechanisms behind cone death under the degenerative state of retinal dystrophies and how the activation of the apoptotic pathway is triggered will provide valuable knowledge. It will also have broader applications for a spectrum of visual disorders and will be critical for future advances in translational research.

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Authors and Affiliations

  1. Department of Ophthalmology, Ocular Genomics Institute, Schepens Eye Research Institute, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Harvard University, 20 Staniford Street, 02114, Boston, MA, USA

    Livia S. Carvalho & Luk H. Vandenberghe

Authors
  1. Livia S. Carvalho
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  2. Luk H. Vandenberghe
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Corresponding author

Correspondence to Livia S. Carvalho .

Editor information

Editors and Affiliations

  1. Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina, USA

    Catherine Bowes Rickman

  2. Beckman Vision Center, University of California, San Francisco School of Medicine, San Francisco, California, USA

    Matthew M. LaVail

  3. Dean A. McGee Eye Inst., University of Oklahoma Health Science Center, Oklahoma City, Oklahoma, USA

    Robert E. Anderson

  4. University Hospital Zurich, Zurich, Switzerland

    Christian Grimm

  5. Case Western Reserve University Cleveland Clinic Lerner College of Med, Cleveland, Ohio, USA

    Joe Hollyfield

  6. Univ of Florida Dept of Ophthalmology/Arb R112, Gainesville, Florida, USA

    John Ash

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© 2016 Springer International Publishing Switzerland

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Carvalho, L., Vandenberghe, L. (2016). Understanding Cone Photoreceptor Cell Death in Achromatopsia. In: Bowes Rickman, C., LaVail, M., Anderson, R., Grimm, C., Hollyfield, J., Ash, J. (eds) Retinal Degenerative Diseases. Advances in Experimental Medicine and Biology, vol 854. Springer, Cham. https://doi.org/10.1007/978-3-319-17121-0_31

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