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Stem Cell Biology in Neoplasms of the Central Nervous System pp 23–32Cite as

The SVZ and Its Relationship to Stem Cell Based Neuro-oncogenesis

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 853))

Abstract

Gliomas are primary cancers of the brain and the most lethal cancers known to man. In recent years the discovery of germinal regions in the postnatal brain containing neuronal stem and progenitor cell populations has led to the hypothesis that these cells may themselves serve as an origin of brain tumors. Stem cells that reside within the glioma tumor have been shown to display nonneoplastic stem-like characteristics, including expression of various stem cell markers, as well as capacity for self-renewal and multipotency. Furthermore, glioma tumors display marked similarities to the germinal regions of the brain. Investigations of human neural stem cells and their potential for malignancy may finally identify a cell-of-origin for human gliomas. This, in turn, may facilitate better therapeutic targeting leading to improved prognosis for glioma patients.

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Author information

Authors and Affiliations

  1. Barrow Brain Tumor Research Center, 350 W. Thomas Road, Phoenix, AZ, 85013, USA

    Yael Kusne & Nader Sanai

Authors
  1. Yael Kusne
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  2. Nader Sanai
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Corresponding author

Correspondence to Nader Sanai .

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Editors and Affiliations

  1. Department of Neurosurgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA

    Moneeb Ehtesham

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Kusne, Y., Sanai, N. (2015). The SVZ and Its Relationship to Stem Cell Based Neuro-oncogenesis. In: Ehtesham, M. (eds) Stem Cell Biology in Neoplasms of the Central Nervous System. Advances in Experimental Medicine and Biology, vol 853. Springer, Cham. https://doi.org/10.1007/978-3-319-16537-0_2

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