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IgE Immunotherapy Against Cancer

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IgE Antibodies: Generation and Function

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 388))

Abstract

The success of antibody therapy in cancer is consistent with the ability of these molecules to activate immune responses against tumors. Experience in clinical applications, antibody design, and advancement in technology have enabled antibodies to be engineered with enhanced efficacy against cancer cells. This allows re-evaluation of current antibody approaches dominated by antibodies of the IgG class with a new light. Antibodies of the IgE class play a central role in allergic reactions and have many properties that may be advantageous for cancer therapy. IgE-based active and passive immunotherapeutic approaches have been shown to be effective in both in vitro and in vivo models of cancer, suggesting the potential use of these approaches in humans. Further studies on the anticancer efficacy and safety profile of these IgE-based approaches are warranted in preparation for translation toward clinical application.

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Acknowledgments

Our work has been supported in part by grants from NIH/NCI: R41CA137881, R01CA136841, R01CA18115, K01CA138559, R21CA179680, and the Susan G. Komen Breast Cancer Foundation Basic, Clinical and Translational Research Grant BCTR0706771.

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  1. Division of Surgical Oncology, Department of Surgery, David Geffen School of Medicine, University of California, Los Angeles, 10833 Le Conte Avenue, CHS 54-140, Box 951782, Los Angeles, CA, 90095-1782, USA

    Lai Sum Leoh, Tracy R. Daniels-Wells & Manuel L. Penichet

  2. Department of Microbiology, Immunology, and Molecular Genetics, University of California, 609 Charles E. Young Dr. East, 1602 Molecular Science Building, Los Angeles, CA, 90095, USA

    Manuel L. Penichet

  3. The Jonsson Comprehensive Cancer Center, University of California, 10833 Le Conte Ave, 8-684 Factor Building, Box 951781, Los Angeles, CA, 90095, USA

    Manuel L. Penichet

  4. The Molecular Biology Institute, University of California, 611 Charles E. Young Dr., Los Angeles, CA, 90095, USA

    Manuel L. Penichet

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Correspondence to Tracy R. Daniels-Wells or Manuel L. Penichet .

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  1. Skirball Institute and Department of Pathology, New York University School of Medicine, New York, USA

    Juan J. Lafaille

  2. Singapore Immunology Network (SIgN), Agency for Science, Technology and Research, Singapore, Singapore

    Maria A. Curotto de Lafaille

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Leoh, L.S., Daniels-Wells, T.R., Penichet, M.L. (2015). IgE Immunotherapy Against Cancer. In: Lafaille, J., Curotto de Lafaille, M. (eds) IgE Antibodies: Generation and Function. Current Topics in Microbiology and Immunology, vol 388. Springer, Cham. https://doi.org/10.1007/978-3-319-13725-4_6

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