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Mechanotransduction, Metastasis and Genomic Instability

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Book cover Genomic Instability and Cancer Metastasis

Part of the book series: Cancer Metastasis - Biology and Treatment ((CMBT,volume 20))

Abstract

Cells translate mechanical forces in the environment into biochemical signals in a process called mechanotransduction. In this way, mechanical forces direct cell behavior, including motility, proliferation, and differentiation, and become important in physiological processes such as development and wound healing. Abnormalities in mechanotransduction can lead to aberrant cell behavior and disease, including cancer. Changes in extracellular mechanical forces or defects in mechanosensors can result in misregulation of signaling pathways inside the cell, and ultimately lead to malignancy. Here, we discuss the ways in which physical attributes of the tumor microenvironment can promote metastasis and genomic instability, two hallmark features of cancer.

Authors Allison Simi and Alexandra Piotrowski have contributed equally to this work.

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Abbreviations

2D:

Two-dimensional

3D:

Three-dimensional

αSMA:

α-smooth muscle actin

bFGFBasic:

fibroblast growth factor

ECM:

Extracellular matrix

EGF:

Epidermal growth factor

EMT:

Epithelial-mesenchymal transition

ERK:

Extracellular-signal-regulated kinase

FAK:

Focal adhesion kinase

FGF:

Fibroblast growth factor

GIN:

Genomic instability

IFP:

Interstitial fluid pressure

ILK:

Integrin-linked kinase

MET:

Mechanoelectrical transduction

MLC:

Myosin light chain

MMP:

Matrix metalloproteinase

PDGF:

Platelet-derived growth factor

PI3K:

Phosphoinositide 3-kinase

PTEN:

Phosphatase and tensin homolog

ROCK:

Rho-associated kinase

ROS:

Reactive oxygen species

RTK:

Receptor tyrosine kinase

TAZ:

transcriptional co-activator with PDZ-binding motif

TGF-β:

Transforming growth factor β

VEGF:

Vascular endothelial growth factor

YAP:

Yes-associated protein

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Authors and Affiliations

  1. Department of Chemical & Biological Engineering, Princeton University, 303 Hoyt Laboratory, William Street, 08544, Princeton, NJ, USA

    Allison K. Simi, Alexandra S. Piotrowski & Celeste M. Nelson

  2. Department of Molecular Biology, Princeton University, 303 Hoyt Laboratory, William Street, 08544, Princeton, NJ, USA

    Celeste M. Nelson

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  1. Allison K. Simi
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  2. Alexandra S. Piotrowski
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  3. Celeste M. Nelson
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Correspondence to Celeste M. Nelson .

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  1. Child & Family Research Institute, University of British Columbia, Pediatrics, Vancouver, British Columbia, Canada

    Chris Maxwell

  2. Dept of Cellular & Physiological Sciences, University of British Columbia, Dept. of Cellular & Physiological Sciences, Vancouver, British Columbia, Canada

    Cal Roskelley

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Simi, A., Piotrowski, A., Nelson, C. (2015). Mechanotransduction, Metastasis and Genomic Instability. In: Maxwell, C., Roskelley, C. (eds) Genomic Instability and Cancer Metastasis. Cancer Metastasis - Biology and Treatment, vol 20. Springer, Cham. https://doi.org/10.1007/978-3-319-12136-9_7

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