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Regulation of Blood Vessels by Prolactin and Vasoinhibins

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Book cover Recent Advances in Prolactin Research

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 846))

Abstract

Prolactin (PRL) stimulates the growth of new blood vessels (angiogenesis) either directly through actions on endothelial cells or indirectly by upregulating proangiogenic factors like vascular endothelial growth factor (VEGF). Moreover, PRL acquires antiangiogenic properties after undergoing proteolytic cleavage to vasoinhibins, a family of PRL fragments (including 16 kDa PRL) with potent antiangiogenic, vasoconstrictive, and antivasopermeability effects. In view of the opposing actions of PRL and vasoinhibins, the regulation of the proteases responsible for specific PRL cleavage represents an efficient mechanism for controlling blood vessel growth and function. This review briefly describes the vascular actions of PRL and vasoinhibins, and addresses how their interplay could help drive biological effects of PRL in the context of health and disease.

An erratum to this chapter can be found at http://dx.doi.org/10.1007/978-3-319-12114-7_13

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Acknowledgements

We thank Guadalupe Calderón for her artistic illustration, Fernando López-Barrera, Gabriel Nava, and Francisco Javier Valles Valenzuela for their technical assistance, and Dorothy D. Pless for critically editing the manuscript. This work was supported by grants from the National Council of Science and Technology of Mexico (161594 and 179496) and from UNAM (IN200312).

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Authors and Affiliations

  1. Instituto de Neurobiología, Universidad Nacional Autónoma de México, Campus UNAM-Juriquilla, 76230, Querétaro, QRO, México

    Dr. Carmen Clapp, Stéphanie Thebault, Yazmín Macotela, Bibiana Moreno-Carranza, Jakob Triebel & Gonzalo Martínez de la Escalera

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  1. Dr. Carmen Clapp
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  2. Stéphanie Thebault
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  1. Department of Biological Sciences, University of Toledo, Toledo, Ohio, USA

    Maria Diakonova, PhD

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Clapp, C., Thebault, S., Macotela, Y., Moreno-Carranza, B., Triebel, J., Martínez de la Escalera, G. (2015). Regulation of Blood Vessels by Prolactin and Vasoinhibins. In: Diakonova, PhD, M. (eds) Recent Advances in Prolactin Research. Advances in Experimental Medicine and Biology, vol 846. Springer, Cham. https://doi.org/10.1007/978-3-319-12114-7_4

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