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Non-Neoplastic Findings

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The Bethesda System for Reporting Cervical Cytology

Abstract

The category “negative for intraepithelial lesion or malignancy” is used for specimens that show a spectrum of nonneoplastic changes, including those associated with protective and reactive responses to inflammation, hormonal alterations, and colonizing or infectious organisms. Recognition of the wide variety of normal cellular presentations is key for the accurate discrimination from neoplastic conditions. Many characteristic patterns of reaction in normal cells can be important clues to the underlying causative process. Some of these patterns have features which are also seen in neoplasia, hence recognition of the key reactive changes is essential for overall accuracy. An expanded variety of “normal” findings as well as non-neoplastic mimics of classic epithelial abnormalities are included in this chapter, providing a more complete representation of the morphologic variations that can be encountered in cervical cytology preparations.

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Author information

Authors and Affiliations

  1. Department of Pathology and Laboratory Medicine, University of Wisconsin, Wisconsin State Laboratory of Hygiene, 465 Henry Mall, Madison, WI, 53706, USA

    Daniel F. I. Kurtycz MD

  2. Department of Pathology, University of Maryland School of Medicine, 22 South Greene Street, Baltimore, MD, 21201, USA

    Paul N. Staats MD

  3. Department of Pathology and Laboratory Medicine, Einstein Healthcare Network, 5501 Old York Road, Philadelphia, PA, 19141, USA

    Nancy A. Young MD

  4. Department of Pathology, Thomas Jefferson University Hospital, 132 s 10th street, Philadelphia, PA, 19107, USA

    Marluce Bibbo MD

  5. Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, ON, Canada

    Terrence J. Colgan MD, FRCP(C), FCAP, MIAC

  6. Department of Pathology, 8829 Ladue Road, Ladue, Missouri, 63124, USA

    Marianne U. Prey MD

  7. Department of Pathology, Northwestern University, Feinberg School of Medicine, Northwestern Memorial Hospital, 251 East Huron Street, Galter, 7-132B, Chicago, IL, 60611, USA

    Ritu Nayar MD

Authors
  1. Daniel F. I. Kurtycz MD
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  2. Paul N. Staats MD
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  3. Nancy A. Young MD
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  4. Marluce Bibbo MD
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  5. Terrence J. Colgan MD, FRCP(C), FCAP, MIAC
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  6. Marianne U. Prey MD
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  7. Ritu Nayar MD
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Corresponding author

Correspondence to Daniel F. I. Kurtycz MD .

Editor information

Editors and Affiliations

  1. Department of Pathology, Northwestern Memorial Hospital, Chicago, Illinois, USA

    Ritu Nayar

  2. Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts, USA

    David C. Wilbur

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Kurtycz, D.F.I. et al. (2015). Non-Neoplastic Findings. In: Nayar, R., Wilbur, D. (eds) The Bethesda System for Reporting Cervical Cytology. Springer, Cham. https://doi.org/10.1007/978-3-319-11074-5_2

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  • DOI: https://doi.org/10.1007/978-3-319-11074-5_2

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-11073-8

  • Online ISBN: 978-3-319-11074-5

  • eBook Packages: MedicineMedicine (R0)

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