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Meroterpenoids from Marine Microorganisms: Potential Scaffolds for New Chemotherapy Leads

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Handbook of Anticancer Drugs from Marine Origin

Abstract

Meroterpenoids, including several biologically active metabolites from marine microorganisms mainly fungi and actinomycete bacteria, represent promising structural scaffolds with not only diverse biological activities such as antimicrotubule, cytotoxic and antiproliferative but also different mechanisms of action. In this chapter, an overview on structural diversity and anticancer activity of mixed biogenesis terpenoid derivatives (meroterpenoids) from marine microorganisms is presented with highlight on individual examples of the most promising candidates in cancer chemotherapy and prevention.

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Acknowledgments

This work was partially supported by the European Regional Development Fund (ERDF) through the COMPETE—Operational Competitiveness Program and national funds through FCT—Foundation for Science and Technology, under the project PEst-C/MAR/LA0015/2013”, and by the Project MARBIOTECH (reference NORTE-07-0124-FEDER-000047) within the SR&TD Integrated Program MARVALOR-Building research and innovation capacity for improved management and valorization of marine resources, supported by the Programa Operacional Regional do Norte (ON.2-O Novo Norte) and by the European Regional Development Fund. Nelson G. M. Gomes thanks Fundação para a Ciência e Tecnologia (FCT) for the scholarship (SFRH/BD/65671/2009) supported by the European Social Fund (ESF).

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  1. ICBAS—Instituto de Ciências Biomédicas Abel Salazar and Centro Interdisciplinar de Investigação Marinha e Ambiental (CIIMAR), Universidade do Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313, Porto, Portugal

    Nelson G. M. Gomes, Suradet Buttachon & Anake Kijjoa Prof.

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  1. Nelson G. M. Gomes
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  2. Suradet Buttachon
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  3. Anake Kijjoa Prof.
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Correspondence to Anake Kijjoa Prof. .

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  1. Department of Marine-Bio Convergence Science, Pukyong National University, Busan, Korea, Republic of (South Korea)

    Se-Kwon Kim

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Gomes, N., Buttachon, S., Kijjoa, A. (2015). Meroterpenoids from Marine Microorganisms: Potential Scaffolds for New Chemotherapy Leads. In: Kim, SK. (eds) Handbook of Anticancer Drugs from Marine Origin. Springer, Cham. https://doi.org/10.1007/978-3-319-07145-9_16

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