Skip to main content

Biology of Giant Cell Tumor

  • Chapter
  • First Online:
Atlas of Musculoskeletal Tumors and Tumorlike Lesions
  • 2558 Accesses

Abstract

Giant cell tumor (GCT) of bone is a well-vascularized tissue made up of a network of spindle-shaped mononuclear stromal cells that represent the proliferating pattern, round mononuclear monocytes, and multinucleated giant cells.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 119.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 159.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Similar content being viewed by others

Bibliography

  • Balla P, Moskovszky L, Sapi Z, Forsyth R, Knowles H, Athanasou NA, Szendroi M, Kopper L, Rajnai H, Pinter F, Petak I, Benassi MS, Picci P, Conti A, Krenacs T (2011) Epidermal growth factor receptor signalling contributes to osteoblastic stromal cell proliferation, osteoclastogenesis and disease progression in giant cell tumour of bone. Histopathology 59(3):376–389

    Article  PubMed  Google Scholar 

  • Broadhead ML, Clark JC, Dass CR, Choong PF, Myers DE (2011) Therapeutic targeting of osteoclast function and pathways. Expert Opin Ther Targets 15(2):169–181

    Article  PubMed  Google Scholar 

  • Conti A, Rodriguez GC, Chiechi A, Blazquez RM, Barbado V, Krènacs T, Novello C, Pazzaglia L, Quattrini I, Zanella L, Picci P, De Alava E, Benassi MS (2011) Identification of potential biomarkers for giant cell tumor of bone using comparative proteomics analysis. Am J Pathol 178(1):88–97

    Article  CAS  PubMed  Google Scholar 

  • Fujisaki K, Tanabe N, Suzuki N, Mitsui N, Oka H, Ito K, Maeno M (2006) The effect of IL-1alpha on the expression of matrix metalloproteinases, plasminogen activators, and their inhibitors in osteoblastic ROS 17/2.8 cells. Life Sci 78(17):1975–1982

    Article  CAS  PubMed  Google Scholar 

  • Gamberi G, Benassi MS, Ragazzini P, Pazzaglia L, Ponticelli F, Ferrari C, Balladelli A, Mercuri M, Gigli M, Bertoni F, Picci P (2004) Proteases and interleukin-6 gene analysis in 92 giant cell tumors of bone. Ann Oncol 15(3):498–503

    Article  CAS  PubMed  Google Scholar 

  • Gorunova L, Vult von Steyern F, Storlazzi CT, Bjerkehagen B, FollerÃ¥s G, Heim S, Mandahl N, Mertens F (2009) Cytogenetic analysis of 101 giant cell tumors of bone: nonrandom patterns of telomeric associations and other structural aberrations. Genes Chromosomes Cancer 48(7):583–602

    Article  CAS  PubMed  Google Scholar 

  • Heymann D (2012) Anti-RANKL therapy for bone tumours. Basic, pre-clinical and clinical evidence. J Bone Oncol 1:2–11

    Article  Google Scholar 

  • Mosakhani N, Pazzaglia L, Benassi MS, Borze I, Quattrini I, Picci P, Knuutila S (2013) MicroRNA expression profiles in metastatic and non-metastatic giant cell tumor of bone. Histol Histopathol 28(5):671–8

    PubMed  Google Scholar 

  • Moskovszky L, Szuhai K, Krenács T, Hogendoorn PC, Szendroi M, Benassi MS, Kopper L, Füle T, Sápi Z (2009) Genomic instability in giant cell tumor of bone. A study of 52 cases using DNA ploidy, relocalization FISH, and array-CGH analysis. Genes Chromosomes Cancer 48(6):468–479

    Article  CAS  PubMed  Google Scholar 

  • Pazzaglia L, Conti A, Chiechi A, Novello C, Magagnoli G, Astolfi A, Pession A, Krenacs T, Alberghini M, Picci P, Benassi MS (2010) Differential gene expression in classic giant cell tumours of bone: Tenascin C as biological risk factor for local relapses and metastases. Histopathology 57(1):59–72

    Article  PubMed  Google Scholar 

  • Thomas DM, Skubitz KM (2009) Giant cell tumour of bone. Curr Opin Oncol 21(4):338–344

    Article  PubMed  Google Scholar 

  • Wittrant Y, Théoleyre S, Chipoy C, Padrines M, Blanchard F, Heymann D, Rédini F (2004) RANKL/RANK/OPG: new therapeutic targets in bone tumours and associated osteolysis. Biochim Biophys Acta 1704(2):49–57

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Maria Serena Benassi PhD .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2014 Springer International Publishing Switzerland

About this chapter

Cite this chapter

Benassi, M.S. (2014). Biology of Giant Cell Tumor. In: Picci, P., Manfrini, M., Fabbri, N., Gambarotti, M., Vanel, D. (eds) Atlas of Musculoskeletal Tumors and Tumorlike Lesions. Springer, Cham. https://doi.org/10.1007/978-3-319-01748-8_21

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-01748-8_21

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-01747-1

  • Online ISBN: 978-3-319-01748-8

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics