Abstract
Oscillators are one of the best studied synthetic genetic circuits and a focus of the emerging field of Synthetic Biology. A number of different feedback arrangements that can produce oscillations have been proposed; the two most important constructs involve a single gene with negative feedback including delay and three genes in negative feedback forming a structure called a repressilator. Each of these has a different range of performance characteristics and different design rules. In this book chapter we discuss how oscillators of the first type can be designed to meet frequency and amplitude requirements. We also discuss how coupling heterogeneous populations of delayed oscillators can produce oscillations with robust amplitude and frequency. The analysis and design is rooted in techniques from control theory and dynamical systems.
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© 2014 Springer International Publishing Switzerland
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Lambert, E., Hancock, E.J., Papachristodoulou, A. (2014). Engineering a Genetic Oscillator Using Delayed Feedback. In: VyhlÃdal, T., Lafay, JF., Sipahi, R. (eds) Delay Systems. Advances in Delays and Dynamics, vol 1. Springer, Cham. https://doi.org/10.1007/978-3-319-01695-5_28
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DOI: https://doi.org/10.1007/978-3-319-01695-5_28
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-01694-8
Online ISBN: 978-3-319-01695-5
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