Skip to main content
SpringerLink
Log in
Birkhäuser
Book cover

The Carbonic Anhydrases

New Horizons

  • Book
  • © 2000

Overview

Editors:
  1. W. Richard Chegwidden

    1. Lake Erie College of Osteopathic Medicine, Erie, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  2. Nicholas D. Carter

    1. Medical Genetics Unit, St George’s Hospital Medical School, London, UK

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  3. Yvonne H. Edwards

    1. MRC Human Biochemical Genetics Unit, Wolfson House, University College London, London, UK

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Experientia Supplementum (EXS, volume 90)

This is a preview of subscription content, log in via an institution to check access.

Access this book

Log in via an institution
eBook USD 259.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 329.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 329.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access

Licence this eBook for your library

Institutional subscriptions

Table of contents (31 chapters)

  1. Front Matter

    Pages I-XVIII
    Download chapter PDF

  2. Exordium: Remarks on the discovery of carbonic anhydrase

    1. Remarks on the discovery of carbonic anhydrase

      • Robert E. Forster
      Pages 1-11

    2. Introduction to the carbonic anhydrases

      • W. Richard Chegwidden, Nicholas D. Carter
      Pages 13-28

    3. Evolution and distribution of the carbonic anhydrase gene families

      • David Hewett-Emmett
      Pages 29-76

  3. Carbonic Anhydrase Isoforms and their Expression in Mammals

    1. Front Matter

      Pages 77-77
      Download chapter PDF

    2. An overview of the distribution and function of carbonic anhydrase in mammals

      • Seppo Parkkila
      Pages 79-93

    3. The membrane carbonic anhydrases: from CO2 transport to tumor markers

      • William S. Sly
      Pages 95-104

    4. Carbonic anhydrase (CA)-related proteins (CA-RPs), and transmembrane proteins with CA or CA-RP domains

      • Richard E. Tashian, David Hewett-Emmett, Nick Carter, Nils C. H. Bergenhem
      Pages 105-120

    5. Regulation of the CA1, CA2 and CA3 genes

      • Yvonne Edwards, Felicity Drummond, Jane Sowden
      Pages 121-141

    6. Use of carbonic anhydrase II-deficient mice in uncovering the cellular location of membrane-associated isoforms

      • Yvonne Ridderstråle, Per J. Wistrand, Lena Holm, Nicholas D. Carter
      Pages 143-155

  4. Structure and Mechanism

    1. Front Matter

      Pages 157-157
      Download chapter PDF

    2. X-ray crystallographic studies of mammalian carbonic anhydrase isozymes

      • Travis Stams, David W. Christianson
      Pages 159-174

    3. The catalytic mechanism of mammalian carbonic anhydrases

      • Sven Lindskog, David N. Silverman
      Pages 175-195

    4. Activation of carbonic anhydrase isozymes

      • Claudiu T. Supuran, Andrea Scozzafava
      Pages 197-219

    5. Active-site engineering of carbonic anhydrase and its application to biosensors

      • Jennifer A. Hunt, Charles A. Lesburg, David W. Christianson, Richard B. Thompson, Carol A. Fierke
      Pages 221-240

    6. Folding and stability of human carbonic anhydrase II

      • Uno Carlsson, Bengt-Harald Jonsson
      Pages 241-259

  5. Physiology

    1. Front Matter

      Pages 261-261
      Download chapter PDF

    2. Membrane transport and provision of substrates for carbonic anhydrase: in vertebrates

      • Robert E. Forster, Susanna J. Dodgson
      Pages 263-280

    3. Respiratory and renal roles of carbonic anhydrase in gas exchange and acid-base regulation

      • Erik R. Swenson
      Pages 281-341

    4. The roles of carbonic anhydrase in metabolism, cell growth and cancer in animals

      • W. Richard Chegwidden, Susanna J. Dodgson, Ian M. Spencer
      Pages 343-363
Back to top

Keywords

About this book

Carbonic anhydrase (CA) is a seemingly ubiquitous enzyme of profound physiological importance, which plays essential roles in respiration, acid-base homeostasis, bone resorption, calcification, photosynthesis, several biosynthetic pathways and a variety of processes involving ion, gas and fluid transfer. This enzyme, which is present in at least three gene families (a, ß, ?), has found favour as a model for the study of evolution of gene families and for site-directed mutagenesis in structure/function relationships, for protein folding and for transgenic and gene target studies. Since the early use of CA inhibitors as diuretics and in treating congestive heart failure, the enzyme has been target of considerable clinical attention. Much of this is now focused on endeavours to produce a new generation of such drugs for the effective treatment of glaucoma and other potential applications. Recent data, suggesting links between CA and various disease processes, including cancer, have stimulated further...

Editors and Affiliations

  • Lake Erie College of Osteopathic Medicine, Erie, USA

    W. Richard Chegwidden

  • Medical Genetics Unit, St George’s Hospital Medical School, London, UK

    Nicholas D. Carter

  • MRC Human Biochemical Genetics Unit, Wolfson House, University College London, London, UK

    Yvonne H. Edwards

Bibliographic Information

  • Book Title: The Carbonic Anhydrases

  • Book Subtitle: New Horizons

  • Editors: W. Richard Chegwidden, Nicholas D. Carter, Yvonne H. Edwards

  • Series Title: Experientia Supplementum

  • DOI: https://doi.org/10.1007/978-3-0348-8446-4

  • Publisher: Birkhäuser Basel

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Basel AG 2000

  • Hardcover ISBN: 978-3-7643-5670-5Published: 01 October 2000

  • Softcover ISBN: 978-3-0348-9570-5Published: 05 November 2012

  • eBook ISBN: 978-3-0348-8446-4Published: 11 November 2013

  • Series ISSN: 1664-431X

  • Series E-ISSN: 2504-3692

  • Edition Number: 1

  • Number of Pages: XVIII, 619

  • Topics: Biochemistry, general, Human Physiology, Plant Physiology

Publish with us

Policies and ethics

Back to top

Search

Navigation