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The role of alterations in free radical metabolism in mediating cognitive impairments in Down’s syndrome

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Free Radicals and Aging

Part of the book series: EXS ((EXS,volume 62))

Summary

Down’s syndrome (DS) is a genetic disorder involving an excess of chromosome 21 (trisomy 21) in approximately 96% of the cases and comprises approximately 15% of the population with mental retardation (Heller, 1969). In addition to the constitutional mental deficiencies associated with the syndrome many DS patients develop dementia associated with Alzheimer’s disease (AD) in their later years of life (Thase et al., 1984). The genetic locus for Cu,Zn-superoxide dismutase (SOD1), a key enzyme in free radical metabolism, is located on chromosome 21, and the activity level of this enzyme is elevated by approximately 50% in a variety of cells of DS patients (see Kedziora and Bartosz, 1988; Sinet, 1982). Because alterations in free radical metabolism may be involved in neuronal death and may be associated with a number of pathological manifestations of DS, it is important to understand the role of free radical metabolism in cognitive impairments of DS, the topic discussed in this chapter.

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Authors and Affiliations

  1. Department of Neuroscience’s and Department of Psychiatry, University of California, 92039, San Diego, CA, USA

    Karen L. Brugge, Sharon Nichols, Dean Delis, Tsunao Saitoh & Doris Truaner

Authors
  1. Karen L. Brugge
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  2. Sharon Nichols
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  3. Dean Delis
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  4. Tsunao Saitoh
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  5. Doris Truaner
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Editor information

Editors and Affiliations

  1. C.N.R.S., Institut Biomédical des Cordeliers, Université Pierre et Marie Curie, 15–21, Rue de l’Ecole de Médecine, F-75006, Paris, France

    Ingrid Emerit (Directeur de Recherche) (Directeur de Recherche)

  2. Department of Biochemistry and Biophysics, University of Pennsylvania, D-501 Richards Building, 19104-6089, Philadelphia, PA, USA

    Britton Chance

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© 1992 Birkhäuser Verlag Basel/Switzerland

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Brugge, K.L., Nichols, S., Delis, D., Saitoh, T., Truaner, D. (1992). The role of alterations in free radical metabolism in mediating cognitive impairments in Down’s syndrome. In: Emerit, I., Chance, B. (eds) Free Radicals and Aging. EXS, vol 62. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-7460-1_19

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  • DOI: https://doi.org/10.1007/978-3-0348-7460-1_19

  • Publisher Name: Birkhäuser Basel

  • Print ISBN: 978-3-0348-7462-5

  • Online ISBN: 978-3-0348-7460-1

  • eBook Packages: Springer Book Archive

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