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New Insights into Vibrio cholerae Biofilms from Molecular Biophysics to Microbial Ecology

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Vibrio spp. Infections

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1404))

Abstract

With the discovery that 48% of cholera infections in rural Bangladesh villages could be prevented by simple filtration of unpurified waters and the detection of Vibrio cholerae aggregates in stools from cholera patients it was realized V. cholerae biofilms had a central function in cholera pathogenesis. We are currently in the seventh cholera pandemic, caused by O1 serotypes of the El Tor biotypes strains, which initiated in 1961. It is estimated that V. cholerae annually causes millions of infections and over 100,000 deaths. Given the continued emergence of cholera in areas that lack access to clean water, such as Haiti after the 2010 earthquake or the ongoing Yemen civil war, increasing our understanding of cholera disease remains a worldwide public health priority. The surveillance and treatment of cholera is also affected as the world is impacted by the COVID-19 pandemic, raising significant concerns in Africa. In addition to the importance of biofilm formation in its life cycle, V. cholerae has become a key model system for understanding bacterial signal transduction networks that regulate biofilm formation and discovering fundamental principles about bacterial surface attachment and biofilm maturation. This chapter will highlight recent insights into V. cholerae biofilms including their structure, ecological role in environmental survival and infection, regulatory systems that control them, and biomechanical insights into the nature of V. cholerae biofilms.

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Acknowledgments

C.M.W. is supported by National Institutes of Health (NIH) grants GM139537 and AI158433. J.Y. holds a Career Award at the Scientific Interface from the Burroughs Wellcome Fund and is also supported by the NIH grant DP2GM146253. J.-S.B.T. is a Damon Runyon Fellow supported by the Damon Runyon Cancer Research Foundation (DRG-2446-21).

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  1. Jung-Shen B. Tai and Micah J. Ferrell contributed equally with all other contributors.

Authors and Affiliations

  1. Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT, USA

    Jung-Shen B. Tai & Jing Yan

  2. Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, MI, USA

    Micah J. Ferrell & Christopher M. Waters

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Correspondence to Christopher M. Waters .

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  1. Burnett School of Biomedical Sciences, University of Central Florida, Orlando, FL, USA

    Salvador Almagro-Moreno

  2. Department of Biology, The City College of New York, New York, NY, USA

    Stefan Pukatzki

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Tai, JS.B., Ferrell, M.J., Yan, J., Waters, C.M. (2023). New Insights into Vibrio cholerae Biofilms from Molecular Biophysics to Microbial Ecology. In: Almagro-Moreno, S., Pukatzki, S. (eds) Vibrio spp. Infections. Advances in Experimental Medicine and Biology, vol 1404. Springer, Cham. https://doi.org/10.1007/978-3-031-22997-8_2

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