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Transformer Based Generative Adversarial Network for Liver Segmentation

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Image Analysis and Processing. ICIAP 2022 Workshops (ICIAP 2022)

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Abstract

Automated liver segmentation from radiology scans (CT, MRI) can improve surgery and therapy planning and follow-up assessment in addition to conventional use for diagnosis and prognosis. Although convolution neural networks (CNNs) have became the standard image segmentation tasks, more recently this has started to change towards Transformers based architectures because Transformers are taking advantage of capturing long range dependence modeling capability in signals, so called attention mechanism. In this study, we propose a new segmentation algorithm using a hybrid approach combining the Transformer(s) with the Generative Adversarial Network (GAN) approach. The premise behind this choice is that the self-attention mechanism of the Transformers allows the network to aggregate the high dimensional feature and provide global information modeling. This mechanism provides better segmentation performance compared with traditional methods. Furthermore, we encode this generator into the GAN based architecture so that the discriminator network in the GAN can classify the credibility of the generated segmentation masks compared with the real masks coming from human (expert) annotations. This allows us to extract the high dimensional topology information in the mask for biomedical image segmentation and provide more reliable segmentation results. Our model achieved a high dice coefficient of 0.9433, recall of 0.9515, and precision of 0.9376 and outperformed other Transformer based approaches.

U. Demir and Z. Zhang—Contribute equally to this paper.

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Notes

  1. 1.

    https://competitions.codalab.org/competitions/17094#learn_the_details.

References

  1. Bilic, P., et al.: The liver tumor segmentation benchmark (LiTS). arXiv preprint arXiv:1901.04056 (2019)

  2. Cao, H., et al.: Swin-Unet: Unet-like pure transformer for medical image segmentation. arXiv preprint arXiv:2105.05537 (2021)

  3. Chlebus, G., Schenk, A., Moltz, J.H., van Ginneken, B., Hahn, H.K., Meine, H.: Automatic liver tumor segmentation in CT with fully convolutional neural networks and object-based postprocessing. Sci. Rep. 8(1), 1–7 (2018)

    Article  Google Scholar 

  4. Chuquicusma, M.J., Hussein, S., Burt, J., Bagci, U.: How to fool radiologists with generative adversarial networks? A visual turing test for lung cancer diagnosis. In: 2018 IEEE 15th International Symposium on Biomedical Imaging (ISBI 2018), pp. 240–244. IEEE (2018)

    Google Scholar 

  5. Cornelis, F.H., et al.: Precision of manual two-dimensional segmentations of lung and liver metastases and its impact on tumour response assessment using RECIST 1.1. Eur. Radiol. Exp. 1(1), 1–7 (2017). https://doi.org/10.1186/s41747-017-0015-4

    Article  MathSciNet  Google Scholar 

  6. Goodfellow, I., et al.: Generative adversarial nets. In: Advances in Neural Information Processing Systems, vol. 27 (2014)

    Google Scholar 

  7. Huang, X., Deng, Z., Li, D., Yuan, X.: Missformer: an effective medical image segmentation transformer. arXiv preprint arXiv:2109.07162 (2021)

  8. Isola, P., Zhu, J.Y., Zhou, T., Efros, A.A.: Image-to-image translation with conditional adversarial networks. In: CVPR (2017)

    Google Scholar 

  9. Khosravan, N., Mortazi, A., Wallace, M., Bagci, U.: PAN: projective adversarial network for medical image segmentation. In: Shen, D., et al. (eds.) MICCAI 2019. LNCS, vol. 11769, pp. 68–76. Springer, Cham (2019). https://doi.org/10.1007/978-3-030-32226-7_8

    Chapter  Google Scholar 

  10. Liu, Y., et al.: Cross-modality knowledge transfer for prostate segmentation from CT scans. In: Wang, Q., et al. (eds.) DART/MIL3ID -2019. LNCS, vol. 11795, pp. 63–71. Springer, Cham (2019). https://doi.org/10.1007/978-3-030-33391-1_8

    Chapter  Google Scholar 

  11. Luc, P., Couprie, C., Chintala, S., Verbeek, J.: Semantic segmentation using adversarial networks. In: NIPS Workshop on Adversarial Training, Barcelona, Spain, December 2016. https://hal.inria.fr/hal-01398049

  12. Paszke, A., et al.: Pytorch: an imperative style, high-performance deep learning library. In: Advances in Neural Information Processing Systems, vol. 32 (2019)

    Google Scholar 

  13. Ristea, N.C., et al.: CyTran: cycle-consistent transformers for non-contrast to contrast CT translation. arXiv preprint arXiv:2110.06400 (2021)

  14. Sung, H., et al.: Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J. Clin. 71(3), 209–249 (2021)

    Article  MathSciNet  Google Scholar 

  15. Vaswani, A., et al.: Attention is all you need. In: Advances in Neural Information Processing Systems, vol. 30 (2017)

    Google Scholar 

  16. Wu, H., et al.: CvT: introducing convolutions to vision transformers. In: Proceedings of the IEEE/CVF International Conference on Computer Vision (ICCV), pp. 22–31, October 2021

    Google Scholar 

  17. Zhu, J.Y., Park, T., Isola, P., Efros, A.A.: Unpaired image-to-image translation using cycle-consistent adversarial networks. In: Proceedings of the IEEE International Conference on Computer Vision, pp. 2223–2232 (2017)

    Google Scholar 

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Acknowledgement

This study is partially supported by NIH NCI grants R01-CA246704 and R01-CA240639.

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Correspondence to Ulas Bagci .

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Demir, U. et al. (2022). Transformer Based Generative Adversarial Network for Liver Segmentation. In: Mazzeo, P.L., Frontoni, E., Sclaroff, S., Distante, C. (eds) Image Analysis and Processing. ICIAP 2022 Workshops. ICIAP 2022. Lecture Notes in Computer Science, vol 13374. Springer, Cham. https://doi.org/10.1007/978-3-031-13324-4_29

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  • DOI: https://doi.org/10.1007/978-3-031-13324-4_29

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