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Cancer Stem Cell Markers and Related Network Pathways pp 141–156Cite as

Abnormal Glycosylation in Cancer Cells and Cancer Stem Cells as a Therapeutic Target

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1393))

Abstract

Tumor resistance and recurrence have been associated with the presence of cancer stem cells (CSCs) in tumors. The functions and survival of the CSCs have been associated with several intracellular and extracellular features. Particularly, the abnormal glycosylation of these signaling pathways and markers of CSCs have been correlated with maintaining survival, self-renewal and extravasation properties. Here, we highlight the importance of glycosylation in promoting the stemness character of CSCs and the current strategies for targeting abnormal glycosylation toward generating effective therapies against the CSC population.

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Authors and Affiliations

  1. Innovation Center of Nanomedicine (iCONM), Kawasaki Institute of Industrial Promotion, 3-25-14 Tonomachi, Kawasaki-ku, Kawasaki, 210-0821, Japan

    Sabina Quader

  2. Division of Risk Assessment, Center for Biological Safety and Research, National Institute of Health Sciences, 3-25-26 Tonomachi, Kawasaki-ku, Kawasaki, 210-9501, Japan

    Shihori Tanabe

  3. Department of Bioengineering, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8656, Japan

    Horacio Cabral

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  1. Sabina Quader
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  2. Shihori Tanabe
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  3. Horacio Cabral
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Correspondence to Horacio Cabral .

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  1. National Institute of Health Sciences, Kanagawa, Japan

    Shihori Tanabe

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Quader, S., Tanabe, S., Cabral, H. (2022). Abnormal Glycosylation in Cancer Cells and Cancer Stem Cells as a Therapeutic Target. In: Tanabe, S. (eds) Cancer Stem Cell Markers and Related Network Pathways. Advances in Experimental Medicine and Biology, vol 1393. Springer, Cham. https://doi.org/10.1007/978-3-031-12974-2_7

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