Abstract
The Middle East is known as the cradle of civilization. It was the crossroads of ancient empires and the birthplace of major world religions. Today, it is the center of many world issues due to economic, religious, and political reasons. Although it has lagged behind many other regions of the world in medicinal research, this has increased dramatically in recent years with increasing numbers of relevant publications. Much of this research has focused on increasing our understanding of the aging process and attempting to identify biomarkers and natural products to improve the human health span. This review provides a brief overview of the research conducted in the Middle East on the health benefits of curcumin, a phytochemical derived from the famous spice turmeric. These efforts have been mainly spearheaded by Iran.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Hajjar RR, Atli T, Al-Mandhari Z, Oudrhiri M, Balducci L, Silbermann M (2013) Prevalence of aging population in the Middle East and its implications on cancer incidence and care. Ann Oncol 24(Suppl 7):vii11–vii24. https://doi.org/10.1093/annonc/mdt268
Cao B, Bray F, Ilbawi A, Soerjomataram I (2018) Effect on longevity of one-third reduction in premature mortality from non-communicable diseases by 2030: a global analysis of the Sustainable Development Goal health target. Lancet Glob Health 6(12):e1288–e1296. https://doi.org/10.1016/S2214-109X(18)30411-X
Ergin V, Bali EB, Hariry RE, Karasu C (2013) Natural products and the aging process. Horm Mol Biol Clin Investig 16(2):55–64
Prasad S, Aggarwal BB (2011) Turmeric, the golden spice: from traditional medicine to modern medicine. In: Benzie IFF, Wachtel-Galor S (eds) Herbal medicine: biomolecular and herbal medicine: biomolecular and clinical aspects, 2nd edn. CRC Press/Taylor & Francis, Boca Raton, FL, pp 263–288
Vogel H, Pelletier J (1815) Curcumin – biological and medicinal properties. J de Pharmacie I:289
Milobedzka J, Kostanecki S, Lampe V (1910) Zur Kenntnis des curcumins. Ber Deut Chem Ges 43:2163–2170
Schraufstatter E, Bernt H (1949) Antibacterial action of curcumin and related compounds. Nature 164(4167):456. https://doi.org/10.1038/164456a0
http://www.karvycommodities.com/downloads/karvySpecialReports/karvysSpecialReports_20080820_01.pdf
https://www.quora.com/Which-is-the-major-country-for-exporting-turmeric
Kunnumakkara AB, Bordoloi D, Padmavathi G, Monisha J, Kishor Roy N, Prasad S et al (2017) Curcumin, the golden nutraceutical: multitargeting for multiple chronic diseases. Br J Pharmacol 174(11):1325–1348
Mantzorou M, Pavlidou E, Vasios G, Tsagalioti E, Giaginis C (2018) Effects of curcumin consumption on human chronic diseases: a narrative review of the most recent clinical data. Phytother Res 32(6):957–975
Soleimani V, Sahebkar A, Hosseinzadeh H (2018) Turmeric (Curcuma longa) and its major constituent (curcumin) as nontoxic and safe substances: Review. Phytother Res 32(6):985–995. https://doi.org/10.1002/ptr.6054. Epub 2018 Feb 26. PMID: 29480523
Dei Cas M, Ghidoni R (2019) Dietary curcumin: correlation between bioavailability and health potential. Nutrients 11(9):E2147. https://doi.org/10.3390/nu11092147
Zhao S, Pi C, Ye Y, Zhao L, Wei Y (2019) Recent advances of analogues of curcumin for treatment of cancer. Eur J Med Chem 180:524–535
Cheng Z, Lin H, Wang Z, Yang X, Zhang M, Liu X et al (2020) Preparation and characterization of dissolving hyaluronic acid composite microneedles loaded micelles for delivery of curcumin. Drug Deliv Transl Res. https://doi.org/10.1007/s13346-020-00735-2
Moballegh Nasery M, Abadi B, Poormoghadam D, Zarrabi A, Keyhanvar P, Khanbabaei H et al (2020) Curcumin delivery mediated by bio-based nanoparticles: a review. Molecules 25(3):E689. https://doi.org/10.3390/molecules25030689
Swami Vetha BS, Oh PS, Kim SH, Jeong HJ (2020) Curcuminoids encapsulated liposome nanoparticles as a blue light emitting diode induced photodynamic therapeutic system for cancer treatment. J Photochem Photobiol B 205:111840. https://doi.org/10.1016/j.jphotobiol.2020.111840
Liczbiński P, Michałowicz J, Bukowska B (2020) Molecular mechanism of curcumin action in signaling pathways: review of the latest research. Phytother Res. https://doi.org/10.1002/ptr.6663
Dai Q, Zhou D, Xu L, Song X (2018) Curcumin alleviates rheumatoid arthritis-induced inflammation and synovial hyperplasia by targeting mTOR pathway in rats. Drug Des Devel Ther 12:4095–4105
Liu R, Zhang HB, Yang J, Wang JR, Liu JX, Li CL (2018) Curcumin alleviates isoproterenol-induced cardiac hypertrophy and fibrosis through inhibition of autophagy and activation of mTOR. Eur Rev Med Pharmacol Sci 22(21):7500–7508
Hu S, Xu Y, Meng L, Huang L, Sun H (2018) Curcumin inhibits proliferation and promotes apoptosis of breast cancer cells. Exp Ther Med 16(2):1266–1272
Wang N, Feng T, Liu X, Liu Q (2020) Curcumin inhibits migration and invasion of non-small cell lung cancer cells through up-regulation of miR-206 and suppression of PI3K/AKT/mTOR signaling pathway. Acta Pharma 70(3):399–409
Wiederrecht GJ, Sabers CJ, Brunn GJ, Martin MM, Dumont FJ, Abraham RT (1995) Mechanism of action of rapamycin: new insights into the regulation of G1-phase progression in eukaryotic cells. Prog Cell Cycle Res 1:53–71
Rosner M, Hanneder M, Siegel N, Valli A, Fuchs C, Hengstschläger M (2008) The mTOR pathway and its role in human genetic diseases. Mutat Res 659(3):284–292
O' Neill C (2013) PI3-kinase/Akt/mTOR signaling: impaired on/off switches in aging, cognitive decline and Alzheimer’s disease. Exp Gerontol 48(7):647–653
Maiese K (2017) Moving to the rhythm with clock (circadian) genes, autophagy, mTOR, and SIRT1 in degenerative disease and cancer. Curr Neurovasc Res 14(3):299–304
Papadopoli D, Boulay K, Kazak L, Pollak M, Mallette F, Topisirovic I et al (2019) mTOR as a central regulator of lifespan and aging. F1000Res 8:F1000 Faculty Rev-998. https://doi.org/10.12688/f1000research.17196.1
Javadi M, Khadem Haghighian H, Goodarzy S, Abbasi M, Nassiri-Asl M (2019) Effect of curcumin nanomicelle on the clinical symptoms of patients with rheumatoid arthritis: a randomized, double-blind, controlled trial. Int J Rheum Dis 22(10):1857–1862
Mohammadi Z, Sharif Zak M, Majdi H, Mostafavi E, Barati M, Lotfimehr H et al (2019) The effect of chrysin-curcumin-loaded nanofibres on the wound-healing process in male rats. Artif Cells Nanomed Biotechnol 47(1):1642–1652
Sadeghi N, Mansoori A, Shayesteh A, Hashemi SJ (2019) The effect of curcumin supplementation on clinical outcomes and inflammatory markers in patients with ulcerative colitis. Phytother Res. https://doi.org/10.1002/ptr.6581
Mirhafez SR, Rezai A, Dehabeh M, Nobakht M Gh BF, Bidkhori M, Sahebkar A et al (2019) Efficacy of phytosomal curcumin among patients with non-alcoholic fatty liver disease. Int J Vitam Nutr Res; Dec:10:1–10:9
Saberi-Karimian M, Keshvari M, Ghayour-Mobarhan M, Salehizadeh L, Rahmani S, Behnam B et al (2020) Effects of curcuminoids on inflammatory status in patients with non-alcoholic fatty liver disease: A randomized controlled trial. Complement Ther Med 49:102322. https://doi.org/10.1016/j.ctim.2020.102322
Cicero AFG, Sahebkar A, Fogacci F, Bove M, Giovannini M, Borghi C (2020) Effects of phytosomal curcumin on anthropometric parameters, insulin resistance, cortisolemia and non-alcoholic fatty liver disease indices: a double-blind, placebo-controlled clinical trial. Eur J Nutr 59(2):477–483
Javidi MA, Kaeidi A, Mortazavi Farsani SS, Babashah S, Sadeghizadeh M (2019) Investigating curcumin potential for diabetes cell therapy, in vitro and in vivo study. Life Sci 239:116908. https://doi.org/10.1016/j.lfs.2019.116908
Hashemzadeh K, Davoudian N, Jaafari MR, Mirfeizi Z (2019) The effect of nanocurcumin on the improvement symptoms of knee osteoarthritis: a randomized clinical trial. Curr Rheumatol Rev. https://doi.org/10.2174/1874471013666191223152658
Ghorbanzadeh R, Assadian H, Chiniforush N, Parker S, Pourakbari B, Ehsani B et al (2019) Modulation of virulence in Enterococcus faecalis cells surviving antimicrobial photodynamic inactivation with reduced graphene oxide-curcumin; an ex vivo biofilm model. Photodiagnosis Photodyn Ther 30:101643. https://doi.org/10.1016/j.pdpdt.2019.101643
Dolati S, Namiranian K, Amerian R, Mansouri S, Arshadi S, Azarbayjani MA (2020) The effect of curcumin supplementation and aerobic training on anthropometric indices serum lipid profiles, C-reactive protein and insulin resistance in overweight women: a randomized, doubleblind, placebo-controlled trial. J Obes Metab Syndr. https://doi.org/10.7570/jomes19055
Karimi Alavijeh R, Akhbari K (2020) Biocompatible MIL-101(Fe) as a smart carrier with high loading potential and sustained release of curcumin. Inorg Chem. https://doi.org/10.1021/acs.inorgchem.9b02756
Esmaeili E, Eslami-Arshaghi T, Hosseinzadeh S, Elahirad E, Jamalpoor Z, Hatamie S et al (2020) The biomedical potential of cellulose acetate/polyurethane nanofibrous mats containing reduced graphene oxide/silver nanocomposites and curcumin: Antimicrobial performance and cutaneous wound healing. Int J Biol Macromol 152:418–427
Elmi T, Ardestani MS, Hajialiani F, Motevalian M, Mohamadi M, Sadeghi S et al (2020) Novel chloroquine loaded curcumin based anionic linear globular dendrimer G2: a metabolomics study on Plasmodium falciparum in vitro using 1HNMR spectroscopy. Parasitology 147(7):747–759. https://doi.org/10.1017/S0031182020000372
Omidi S, Pirhayati M, Kakanejadifard A (2020) Co-delivery of doxorubicin and curcumin by a pH-sensitive, injectable, and in situ hydrogel composed of chitosan, graphene, and cellulose nanowhisker. Carbohydr Polym 231:115745. https://doi.org/10.1016/j.carbpol.2019.115745
Firouzi Amoodizaj F, Baghaeifar S, Taheri E, Farhoudi Sefidan Jadid M, Safi M, Seyyed Sani N et al (2020) Enhanced anticancer potency of doxorubicin in combination with curcumin in gastric adenocarcinoma. J Biochem Mol Toxicol:e22486. https://doi.org/10.1002/jbt.22486
Abhari SMF, Khanbabaei R, Roodbari NH, Parivar K, Yaghmaei P (2020) Curcumin-loaded super-paramagnetic iron oxide nanoparticle affects on apoptotic factors expression and histological changes in a prepubertal mouse model of polycystic ovary syndrome-induced by dehydroepiandrosterone - A molecular and stereological study. Life Sci:117515. https://doi.org/10.1016/j.lfs.2020.117515
Varshosaz J, Jandaghian S, Mirian M, Sajjadi SE (2020) Co-delivery of rituximab targeted curcumin and imatinib nanostructured lipid carriers in non-Hodgkin lymphoma cells. J Liposome Res 6:1–15. https://doi.org/10.1080/08982104.2020.1720718
Karimi M, Gheybi F, Zamani P, Mashreghi M, Golmohammadzadeh S, Amiri Darban S et al (2020) Preparation and characterization of stable nanoliposomal formulations of curcumin with high loading efficacy: in vitro and in vivo anti-tumor study. Int J Pharm:119211. https://doi.org/10.1016/j.ijpharm.2020.119211
Alizadeh N, Malakzadeh S (2020) Antioxidant, antibacterial and anti-cancer activities of β-and γ-CDs/curcumin loaded in chitosan nanoparticles. Int J Biol Macromol 147:778–791
Ghaffari M, Dehghan G, Baradaran B, Zarebkohan A, Mansoori B, Soleymani J et al (2020) Co-delivery of curcumin and Bcl-2 siRNA by PAMAM dendrimers for enhancement of the therapeutic efficacy in HeLa cancer cells. Colloids Surf B Biointerfaces 188:110762. https://doi.org/10.1016/j.colsurfb.2019.110762
Christophi CA, Pampaka D, Paisi M, Ioannou S, DiFranza JR (2016) Levels of physical dependence on tobacco among adolescent smokers in cyprus. Addict Behav 60:148–153
https://www.who.int/violence_injury_prevention/road_traffic/countrywork/egy/en/
Sarrafzadegan N, Mohammmadifard N (2019) Cardiovascular disease in iran in the last 40 years: prevalence, mortality, morbidity, challenges and strategies for cardiovascular prevention. Arch Iran Med 22(4):204–210
https://www.cfr.org/interactive/global-conflict-tracker/conflict/political-instability-iraq
Madanat HN, Troutman KP, Al-Madi B (2008) The nutrition transition in Jordan: the political, economic and food consumption contexts. Promot Educ 15(1):6–10
Zayed AA, Beano AM, Haddadin FI, Radwan SS, Allauzy SA, Alkhayyat MM et al (2016) Prevalence of short stature, underweight, overweight, and obesity among school children in Jordan. BMC Public Health 16(1):1040. https://doi.org/10.1186/s12889-016-3687-4
http://siteresources.worldbank.org/INTTOPGLOROASAF/Resources/TN-MENA-Road-Safety-Dahdah-and-Bose-revised-print.pdf
https://www.thecabinchiangmai.com/international-rehab/drug-rehab-qatar/
https://stepfeed.com/a-car-crash-happens-every-minute-in-saudi-arabia-3428
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2021 The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG
About this chapter
Cite this chapter
Guest, P.C., Sahebkar, A. (2021). Research in the Middle East into the Health Benefits of Curcumin. In: Guest, P.C. (eds) Studies on Biomarkers and New Targets in Aging Research in Iran. Advances in Experimental Medicine and Biology(), vol 1291. Springer, Cham. https://doi.org/10.1007/978-3-030-56153-6_1
Download citation
DOI: https://doi.org/10.1007/978-3-030-56153-6_1
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-030-56152-9
Online ISBN: 978-3-030-56153-6
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)