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International Work-Conference on Bioinformatics and Biomedical Engineering

IWBBIO 2020: Bioinformatics and Biomedical Engineering pp 227–236Cite as

Comorbidity Network Analyses of Global Rheumatoid Arthritis and Type 2 Diabetes Reveal IL2 & IL6 as Common Role Players

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Part of the book series: Lecture Notes in Computer Science ((LNBI,volume 12108))

Abstract

Comorbidities are associated with harder clinical management, worse health outcomes and an overall increase in healthcare expenditure. Here, we present a novel method of finding the common key genes and pathways via comorbidity network analyses. Essentially, we deployed data from the RAvariome database and Type 2 Diabetes Knowledge Portal for mutually exclusive interpopulation RA and T2D susceptibility genes, respectively. Protein interactomes (PIN) are built by mapping direct interactions between the above gene products and their interacting partners, along with a comorbid network combining both RA and T2D PIN. Network centrality analyses of all PIN projected 18 overlapping proteins with IL-6 and IL-2 being the common key role players found in the comorbid PIN, despite being exclusive to our curated RA susceptible gene list. Subsequent pathway analyses revealed the involvement of cellular senescence, MAPK and AGE-RAGE signalling in diabetic complications. We conclude that RA and T2D susceptible genes do not necessarily translate into indispensable proteins in their induced individual or comorbid diseased networks, but those of RA can outcompete T2D susceptible genes despite the much larger T2D component in the comorbid network. Our method is a unique approach to find key genes/proteins and implicated pathways in disease comorbidities.

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Author information

Authors and Affiliations

  1. Sunway University, 47500, Petaling Jaya, Selangor, Malaysia

    Tuck Onn Liew & Chandrajit Lahiri

  2. Guru Nanak Khalsa College, Mumbai, 400019, Maharashtra, India

    Rohit Mishra

Authors
  1. Tuck Onn Liew
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  2. Rohit Mishra
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  3. Chandrajit Lahiri
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Contributions

RM constructed the interactome and compiled the implicated proteins and pathways. LTO wrote the manuscript and corrected the analysis. CL checked and corrected the manuscript and headed the project. The authors declare no conflicts of interest.

Corresponding author

Correspondence to Chandrajit Lahiri .

Editor information

Editors and Affiliations

  1. University of Granada, Granada, Spain

    Ignacio Rojas

  2. University of Granada, Granada, Spain

    Olga Valenzuela

  3. University of Granada, Granada, Spain

    Fernando Rojas

  4. University of Granada, Granada, Spain

    Luis Javier Herrera

  5. University of Chicago and Fundacion Progreso y Salud, Granada, Spain

    Francisco Ortuño

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Liew, T.O., Mishra, R., Lahiri, C. (2020). Comorbidity Network Analyses of Global Rheumatoid Arthritis and Type 2 Diabetes Reveal IL2 & IL6 as Common Role Players. In: Rojas, I., Valenzuela, O., Rojas, F., Herrera, L., Ortuño, F. (eds) Bioinformatics and Biomedical Engineering. IWBBIO 2020. Lecture Notes in Computer Science(), vol 12108. Springer, Cham. https://doi.org/10.1007/978-3-030-45385-5_21

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  • DOI: https://doi.org/10.1007/978-3-030-45385-5_21

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-45384-8

  • Online ISBN: 978-3-030-45385-5

  • eBook Packages: Computer ScienceComputer Science (R0)

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