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Effects on Glial Cell Glycolysis in Schizophrenia: An Advanced Aging Phenotype?

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Reviews on Biomarker Studies in Aging and Anti-Aging Research

Part of the book series: Advances in Experimental Medicine and Biology ((PMISB,volume 1178))

Abstract

Schizophrenia is a severe and debilitating psychiatric disorder believed to have neurodevelopmental origins. Several studies have associated energy metabolism dysfunction with the disorder, mostly related to glycolysis alterations. Glucose is the obligatory energy substrate of the brain and glycolysis is the first step for its metabolism. This takes place predominantly in glial cells, astrocytes and oligodendrocytes, whereas neurons present a predominant oxidative profile. Thus, glial cells generate either lactate or pyruvate to neurons for ATP production. In addition, some aspects of schizophrenia may reflect an advanced aging phenotype with effects on various neural cell types at different stages of the disease. Given the role of glial cells in brain energy metabolism, the association of glycolysis dysfunction and the accelerated aging of neuronal cells in schizophrenia, studies focusing on those aspects can yield important insights into the causes and implications of the disorder. In turn, this may lead to novel therapeutic strategies for improved treatment of individuals suffering with this disorder.

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Acknowledgements

The authors are supported by FAPESP (São Paulo Research Foundation; grants 2017/25588-1, 2018/14666-4), Serrapilheira Institute (grant Serra-1709-16349), and CNPq (Brazilian National Council for Scientific and Technological Development; grant 302453/2017-2)

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Authors and Affiliations

  1. Laboratory of Neuroproteomics, Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas (UNICAMP), Campinas, Brazil

    Giuliana S. Zuccoli, Paul C. Guest & Daniel Martins-de-Souza

  2. Instituto Nacional de Biomarcadores em Neuropsiquiatria (INBION) Conselho Nacional de Desenvolvimento Cientifico e Tecnologico, São Paulo, Brazil

    Daniel Martins-de-Souza

  3. UNICAMP’s Neurobiology Center, Campinas, Brazil

    Daniel Martins-de-Souza

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  1. Giuliana S. Zuccoli
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Correspondence to Daniel Martins-de-Souza .

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  1. Laboratory of Neuroproteomics, Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas (UNICAMP), Campinas, Brazil

    Paul C. Guest

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Zuccoli, G.S., Guest, P.C., Martins-de-Souza, D. (2019). Effects on Glial Cell Glycolysis in Schizophrenia: An Advanced Aging Phenotype?. In: Guest, P. (eds) Reviews on Biomarker Studies in Aging and Anti-Aging Research. Advances in Experimental Medicine and Biology(), vol 1178. Springer, Cham. https://doi.org/10.1007/978-3-030-25650-0_2

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