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ATAD3A on the Path to Cancer

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Reviews on Biomarker Studies of Metabolic and Metabolism-Related Disorders

Part of the book series: Advances in Experimental Medicine and Biology ((PMISB,volume 1134))

Abstract

The ATPase family AAA-domain containing protein 3A (ATAD3A), a nuclear-encoded mitochondrial enzyme, is involved in diverse cellular processes, including mitochondrial dynamics, cell death and cholesterol metabolism. Overexpression and/or mutation of the ATAD3A gene have been observed in different types of cancer, associated with cancer development and progression. The dysregulated ATAD3A acts as a broker of a mitochondria-endoplasmic reticulum connection in cancer cells, and inhibition of this enzyme leads to tumor repression and enhanced sensitivity to chemotherapy and radiation. As such, ATAD3A is a promising drug target in cancer treatment.

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Acknowledgements

The authors thank Parth Thakkar and Ron Chemmalakuzhy for their proofreading of this chapter.

Author information

Authors and Affiliations

  1. Department of Oral Biology and Diagnostic Sciences, Dental College of Georgia, Augusta University, Augusta, GA, USA

    Yong Teng & Liwei Lang

  2. Georgia Cancer Center, Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta University, Augusta, GA, USA

    Yong Teng

  3. Department of Medical Laboratory, Imaging and Radiologic Sciences, College of Allied Health, Augusta University, Augusta, GA, USA

    Yong Teng

  4. The Robinson College of Business, Georgia State University, Atlanta, GA, USA

    Chloe Shay

  5. Division of Endocrinology and Diabetes, Department of Pediatrics, School of Medicine, Emory University, Atlanta, GA, USA

    Chloe Shay

Authors
  1. Yong Teng
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  2. Liwei Lang
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  3. Chloe Shay
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Corresponding author

Correspondence to Yong Teng .

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Editors and Affiliations

  1. Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas (UNICAMP), Campinas, Brazil

    Paul C. Guest

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Teng, Y., Lang, L., Shay, C. (2019). ATAD3A on the Path to Cancer. In: Guest, P. (eds) Reviews on Biomarker Studies of Metabolic and Metabolism-Related Disorders. Advances in Experimental Medicine and Biology(), vol 1134. Springer, Cham. https://doi.org/10.1007/978-3-030-12668-1_14

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