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Cytokines in the pathogenesis of human African trypanosomiasis: antagonistic roles of TNF-α and IL-10

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Progress in Human African Trypanosomiasis, Sleeping Sickness

Abstract

At the beginning of the twentieth century, human African trypanosomiasis (HAT) or sleeping sickness surpassed all other public health problems in sub-Saharan Africa. By the late 1950s, the incidence of HAT had been decreased in all endemic countries of West and Central Africa as a result of mass detection and treatment campaigns. Political unrest and civil war have disturbed the normal public health infrastructure, causing a resurgence of this devastating protozoal infection in regions of tropical and subtropical Africa. Recent medical surveys reveal shockingly high prevalence (> 700 cases per 1000) in some endemic areas of equatorial Africa [1].

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Authors
  1. S. G. Rhind
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  2. P. N. Shek
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Editors and Affiliations

  1. Faculté de Médecine Institut d’Épidemiologie Neurologique et de Neurologie Tropicale, Université de Limoges, 2, rue du Dr. Marcland, 87025, Limoges, France

    Michel Dumas  & Bernard Bouteille  & 

  2. Unité de Physiologie de la Vigilance, Centre de Recherches du Service de Santé des Armées Émile Pardé, 38702, La Tronche Cedex, France

    Alain Buguet

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Rhind, S.G., Shek, P.N. (1999). Cytokines in the pathogenesis of human African trypanosomiasis: antagonistic roles of TNF-α and IL-10. In: Dumas, M., Bouteille, B., Buguet, A. (eds) Progress in Human African Trypanosomiasis, Sleeping Sickness. Springer, Paris. https://doi.org/10.1007/978-2-8178-0857-4_7

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  • DOI: https://doi.org/10.1007/978-2-8178-0857-4_7

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