Abstract
Ultrasonography is the recommended imaging modality for the evaluation of testicular pathology. MRI can be useful as a problem solving tool if the ultrasonographic images are of suboptimal quality or if a discrepancy between the clinical and sonographic findings arises. For routine staging of testicular carcinoma, MRI has no specific role, unless brain or liver metastases are suspected. In addition, it may be used to clarify specific uncertainties. Thorough imaging of chest, abdomen, and pelvis are required to complete the work-up and staging of a newly diagnosed testicular tumor. Together with tumor marker levels, radiographic staging provides the basis for tumor staging according to the UICC- and IGCCCG-classifications. At testicular carcinoma - staging, any number of nodes within the expected primary/ ipsilateral landing zone, irrespective of their size, should raise serious suspicion of occult metastases. On staging- chest CT images, all pulmonary nodules, regardless of their size, are suspect. Only calcified foci are a safe exception to this rule. In general, PET-CT is now the gold standard providing simultaneously obtained CT and PET images which may then delineate the exact anatomic location of the lesion with a resolution of 5 mm. However, there is no specific benefit in the use of FDG PET for testicular carcinoma staging at presentation.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsReferences
Akin EA, Khati N, Hill MC (2004) Ultrasound of the scrotum. Ultrasound Quarterly 20(4):181–200
Albers P, Bender H, Yilmaz H, Schoeneich G, Biersack HJ, Mueller SC (1999) Positron emission tomography in the clinical staging of patients with Stage I and II testicular germ cell tumors. Urology 53(4):808–811
Albers P, Albrecht W, Algaba F et al (2005) Guidelines on testicular cancer. Eur Urol 48(6):885–894
Albrecht T, Hohmann J, Oldenburg A, Skrok J, Wolf KJ (2004) Detection and characterization of liver metastases. Eur Radiol 14(supp 8):25–33
Atkinson GO, Patrick LE, Ball TI, Stephenson CA, Broecker BH, Woodwatd JR (1992) The normal and abnormal scrotum in children: evaluation with color Doppler sonography. AJR Am J Roentgenol 158(3):613–617
Baker LL, Hajek PC, Burkhard TK et al (1987) MR imaging of the scrotum: pathologic conditions. Radiology 163(1):93–98
Bass JE, Redwine MD, Kramer LA, Huynh PT, Harris JH Jr (2000) Spectrum of congenital anomalies of the inferior vena cava: cross-sectional imaging findings. Radiographics 20(3):639–652
Becherer A, De Santis M, Karanikas G et al (2005) FDG PET is superior to CT in the prediction of viable tumour in post-chemotherapy seminoma residuals. Eur J Radiol 54(2):284–288
Beck SD, Foster RS, Bihrle R et al (2002) Teratoma in the orchiectomy specimen and volume of metastasis are predictors of retroperitoneal teratoma in post- chemotherapy nonseminomatous testis cancer. J Urol 168(4 pt 1):1402–1404
Benson CB (1988) The role of ultrasound in the diagnosis and staging of testicular cancer. Semin Urol 6:189–202
Benson CB, Doubilet PM, Richie JP (1989) Sonography of the male genital tract. AJR Am J Roentgenol 153(4):705–713
Bokemeyer C, Nowak P, Haupt A et al (1997) Treatment of brain metastases in patients with testicular cancer. J Clin Oncol 15(4):1449–1454
Bomanji J, Costa D, Ell P (2001) Clinical role of positron emission tomography in oncology. Lancet Oncol 2(3):157–164
Bosl GJ, Motzer RJ (1997) Testicular germ-cell cancer. N Engl J Med 337(4):242–253
Bradey N, Johnson RJ, Read G (1987) Abdominal computed tomography in teratoma of the testis: its accuracy in stage I disease and an assessment of the distribution of retroperitoneal lymph-node metastases in other stages of the disease. Br J Radiol 60(713):487–491
Brener BJ, Darling RC, Frederick PL, Linton RR (1974) Major venous anomalies complicating abdominal aortic surgery. Arch Surg 108(2):159–165
Brown LR, Aughenbaugh GL (1991) Masses of the anterior mediastinum: CT and MR imaging. AJR Am J Roentgenol 157(6):1171–1180
Budoff MJ, Lu B, Mao S et al (2000) Evaluation of fluid collection in the pericardial sinuses and recesses: noncontrast-enhanced electron beam tomography. Invest Radiol 35(6):359–365
Busch FM, Sayegh ES, Chenault OW Jr (1965) Some uses of lymphangiography in the management of testicular tumors. J Urol 93:490–495
Cagini L, Nicholson AG, Horwich A, Goldstraw P, Pastorino U (1998) Thoracic metastasectomy for germ cell tumours: long term survival and prognostic factors. Ann Oncol 9(11):1185–1191
Carroll BA, Gross DM (1983) High-frequency scrotal sonography. AJR Am J Roentgenol 140(3):511–515
Choi YW, McAdams HP, Jeon SC, Seo HS, Hahm CK (2000) The “High-Riding” superior pericardial recess: CT findings. AJR Am J Roentgenol 175(4):1025–1028
Cohade C, Wahl RL (2002) PET scanning and measuring the impact of treatment. Cancer J 8(2):119–134
Cramer BM, Schlegel EA, Thueroff JW (1991) MR imaging in the differential diagnosis of scrotal and testicular disease. Radiographics 11(1):9–21
Cremerius U, Effert PJ, Adam G et al (1998) FDG PET for detection and therapy control of metastatic germ cell tumor. J Nucl Med 39(5):815–822
Cremerius U, Wildberger JE, Borchers H et al (1999) Does positron emission tomography using 18-fluoro-2-deoxyglucose improve clinical staging of testicular cancer? – Results of a study in 50 patients. Urology 54(5):900–904
Dalal PU, Sohaib S, Huddart R (2006) Imaging of testicular germ cell tumors. Cancer Imaging 6:124–134
Davis PC, Hudgins PA, Peterman SB, Hoffman JC Jr (1991) Diagnosis of cerebral metastases: double-dose delayed CT vs contrast-enhanced MR imaging. AJNR 12(2):293–300
De Santis M, Becherer A, Bokemeyer C et al (2004) 2-18fluoro-deoxy-D-glucose positron emission tomography is a reliable predictor for viable tumor in postchemotherapy seminoma: an update of the prospective multicentric SEMPET trial. J Clin Oncol 22(6):1034–1039
de Wit M, Brenner W, Hartmann M et al (2008) [18F]-FDG-PET in clinical stage I/II non-seminomatous germ cell tumours: results of the German multicentre trial. Ann Oncol19(9): 1619–23
Dixon AK, Ellis M, Sikora K (1986) Computed tomography of testicular tumours: distribution of abdominal lymphadenopathy. Clin Radiol 37(6):519–523
Dogra VS, Gottlieb RH, Oka M et al (2003) Sonography of the scrotum. Radiology 227:18–36
Donohue JP, Zachary JM, Maynard BR (1982) Distribution of nodal metastases in nonseminomatous testis cancer. J Urol 128(2):315–320
Donohue JP, Thornhill JA, Foster RS, Rowland RG, Bihrle R (1993) Primary retroperitoneal lymph node dissection in clinical stage A non-seminomatous germ cell testis cancer. Review of the Indiana University experience 1965-1989. Br J Urol 71(3):326–335
Donohue JP, Thornhill JA, Foster RS, Bihrle R, Rowland RG, Einhorn LH (1995) The role of retroperitoneal lymphadenectomy in clinical stage B testis cancer: the Indiana University experience (1965 to 1989). J Urol 153(1):85–89
Dorfman RE, Alpern MB, Gross BH, Sandler MA (1991) Upper abdominal lymph nodes: criteria for normal size determined with CT. Radiology 180(2):319–322
Dubowitz DJ (1997) Problem in diagnostic imaging. Clin Anat 10(4):279–282
Eary JF (1999) Nuclear medicine in cancer diagnosis. Lancet 354(9181):853–857
Ellis JH, Bies JR, Kopecky KK, Klatte EC, Rowland RG, Donohue JP (1984) Comparison of NMR and CT imaging in the evaluation of metastatic retroperitoneal lymphadenopathy from testicular carcinoma. J Comput Assist Tomogr 8(4):709–719
Engenhart R, Kimmig BN, Strauss LG et al (1992) Therapy monitoring of presacral recurrences after high-dose irradiation: value of PET, CT, CEA and pain score. Strahlenther Onkol 168(4):203–212
Fernandez EB, Moul JW, Foley JP, Colon E, McLeod DG (1994) Retroperitoneal imaging with third and fourth generation computed axial tomography in clinical stage I nonseminomatous germ cell tumors. Urology 44(4):548–552
Forsberg L, Dale L, Hoiem L et al (1986) Computed tomography in early stages of testicular carcinoma. Size of normal retroperitoneal lymph nodes and lymph nodes in patients with metastases in stage II A. A SWENOTECA study: Swedish-Norwegian Testicular Cancer Project. Acta Radiol Diagn (Stockh) 27(5):569–574
Fossa SD, Bokemeyer C, Gerl A et al (1999) Treatment outcome of patients with brain metastases from malignant germ cell tumors. Cancer 85(4):988–997
Fulcher AS, Proto AV, Jolles H (1990) Cystic teratoma of the mediastinum: demonstration of fat/fluid level. AJR Am J Roentgenol 154(2):259–260
Fuse H, Shimazaki J, Katayama T (1990) Ultrasonography of testicular tumors. Eur Urol 17(4):273–275
Gatti JM, Stephenson RA (1998) Staging of testis cancer. Combining serum markers, histologic parameters, and radiographic imaging. Urol Clin North Am 25(3):397–403
Glazer HS, Lee JK, Melson GL (1982) Sonographic detection of occult testicular neoplasms. AJR Am J Roentgenol 138:673–675
Gollub MJ, Castellino RA (1996) The cisterna chyli: a potential mimic of retrocrural lymphadenopathy on CT scans. Radiology 199(2):477–480
Grantham JG, Charboneau J, James EM (1985) Testicular neoplasms: 29 tumors studied by high-resolution ultrasound. Radiology 157:775–780
Guthrie JA, Fowler R (1992) Ultrasound diagnosis of testlar tumors presenting as epididymal disease. Clin Radiol 46:397–400
Haberkorn U, Strauss LG, Dimitrakopoulou A et al (1991) PET studies of fluorodeoxyglucose metabolism in patients with recurrent colorectal tumors receiving radiotherapy. J Nucl Med 32(8):1485–1490
Hain SF, O’Doherty MJ, Timothy AR, Leslie MD, Harper PG, Huddart RA (2000) Fluorodeoxyglucose positron emission tomography in the evaluation of germ cell tumours at relapse. Br J Cancer 83(7):863–869
Hartmann JT, Kanz L, Bokemeyer C (1999) Diagnosis and treatment of patients with testicular germ cell cancer. Drugs 58(2):257–281
Hilton S, Herr HW, Teitcher JB, Begg CB, Castellino RA (1997) CT detection of retroperitoneal lymph node metastases in patients with clinical stage I testicular nonseminomatous germ cell cancer: assessment of size and distribution criteria. AJR Am J Roentgenol 169(2):521–525
Hofer C, Kubler H, Hartung R, Breul J, Avril N (2001) Diagnosis and monitoring of urological tumors using positron emission tomography. Eur Urol 40(5):481–487
Horstman WG, Melson GL, Middleton WD, Andriole GL (1992) Testiculat tumors: findings with color Doppler US. Radiology 185(3):733–737
Horstman WG, Haluszka MM, Burkhard TK (1994) Management of testicular masses incidentally discovered by ultrasound. J Urol 151:1263–1265
Howlett DC, Marchbank ND, Sallomi DF (2000) Ultrasound of the testis. Clin Radiol 55:595–601
Hricak H, Hamm B, Bohyun K (1995) Imaging of the scrotum. Raven, New York
Huddart RA, O’Doherty MJ, Padhani A et al (2007) 18fluorodeoxyglucose positron emission tomography in the prediction of relapse in patients with high-risk, clinical stage I nonseminomatous germ cell tumors: preliminary report of MRC Trial TE22–the NCRI Testis Tumour Clinical Study Group. J Clin Oncol 25(21):3090–3095
Hustinx R, Paulus P, Jacquet N, Jerusalem G, Bury T, Rigo P (1998) Clinical evaluation of whole-body 18F-fluorodeoxyglucose positron emission tomography in the detection of liver metastases. Ann Oncol 9(4):397–401
International Germ Cell Cancer Collaborative Group (1997) International Germ Cell Consensus Classification: a prognostic factor-based staging system for metastatic germ cell cancers. J Clin Oncol 15(2):594–603
Jaffe CC (2006) Measures of response: RECIST, WHO, and new alternatives. J Clin Oncol 24(20):3245–3251
Jerusalem G, Beguin Y, Fassotte MF et al (1999) Whole-body positron emission tomography using 18F-fluorodeoxyglucose for posttreatment evaluation in Hodgkin’s disease and non-Hodgkin’s lymphoma has higher diagnostic and prognostic value than classical computed tomography scan imaging. Blood 94(2):429–433
Jerusalem G, Beguin Y, Fassotte MF et al (2003) Early detection of relapse by whole-body positron emission tomography in the follow-up of patients with Hodgkin’s disease. Ann Oncol 14(1):123–130
Jochelson MS, Garnick MB, Balikian JP, Richie JP (1984) The efficacy of routine whole lung tomography in germ cell tumors. Cancer 54(6):1007–1009
Johns Putra L, Lawrentschuk N, Ballok Z et al (2004) 18F-fluorodeoxyglucose positron emission tomography in evaluation of germ cell tumor after chemotherapy. Urology 64(6):1202–1207
Johnson JO, Mattrey RF, Phillipson J (1990) Differentiation of seminomatous from nonseminomatous testicular tumors with MR imaging. AJR Am J Roentgenol 154(3):539–543
Juweid ME, Wiseman GA, Vose JM et al (2005) Response assessment of aggressive non-Hodgkin’s lymphoma by integrated International Workshop Criteria and fluorine-18-fluorodeoxyglucose positron emission tomography. J Clin Oncol 23(21):4652–4661
Kim W, Rosen MA, Langer JE, Baner MP, Siegelman ES, Ramchandani P (2007) US MR imaging correlation in pathologic conditions of the scrotum. Radiographics 27(5):1239–1253
Kitajima K, Nakamoto Y, Senda M, Onishi Y, Okizuka H, Sugimura K (2007) Normal uptake of (18)F-FDG in the testis: an assessment by PET/CT. Ann Nucl Med 21(7):405–410
Kollmannsberger C, Nichols C, Meisner C, Mayer F, Kanz L, Bokemeyer C (2000) Identification of prognostic subgroups among patients with metastatic ‘IGCCCG poor-prognosis’ germ-cell cancer: an explorative analysis using cart modeling. Ann Oncol 11(9):1115–1120
Kollmannsberger C, Oechsle K, Dohmen B et al (2002) Pros pective comparison of [18F]fluorodeoxyglucose positron emission tomography with conventional assessment by computed tomography scans and serum tumor markers for the evaluation of residual masses in patients with nonseminomatous germ cell carcinoma. Cancer 94(9):2353–2362
Kostakoglu L, Coleman M, Leonard JP, Kuji I, Zoe H, Goldsmith SJ (2002) PET predicts prognosis after 1 cycle of chemotherapy in aggressive lymphoma and Hodgkin’s disease. J Nucl Med 43(8):1018–1027
Kubik-Huch RA, Hailemariam S, Hamm B (1999) CT and MRI of the male genital tract: radiologic-pathologic correlation. Eur Radiol 9(1):16–28
Kubota R, Yamada S, Kubota K, Ishiwata K, Tamahashi N, Ido T (1992) Intratumoral distribution of fluorine-18-fluorodeoxyglucose in vivo: high accumulation in macrophages and granulation tissues studied by microautoradiography. J Nucl Med 33(11):1972–1980
Kullmann G, Lien HH (1987) Intraabdominal hematoma following orchiectomy: a potential pitfall in using CT for staging of testicular cancer. Radiology 163(1):129–130
Lassen U, Daugaard G, Rorth M, Eigtved A, Hojgaard L (2000) Positron emission tomography with 18F-fluoro-deoxyglucose in clinical stage I non-seminomatous germ cell tumors. ASCO Annual Meeting abstract no 1337
Lassen U, Daugaard G, Eigtved A, Hojgaard L, Damgaard K, Rorth M (2003) Whole-body FDG-PET in patients with stage I non-seminomatous germ cell tumours. Eur J Nucl Med Mol Imaging 30(3):396–402
Lee KS, Im JG, Han CH, Han MC, Kim CW, Kim WS (1989) Malignant primary germ cell tumors of the mediastinum: CT features. AJR Am J Roentgenol 153(5):947–951
Leibovitch L, Foster RS, Kopecky KK, Donohue JP (1995) Improved accuracy of computerized tomography based clinical staging in low stage nonseminomatous germ cell cancer using size criteria of retroperitoneal lymph nodes. J Urol 154(5):1759–1763
Levitt RG, Husband JE, Glazer HS (1984) CT of primary germ-cell tumors of the mediastinum. AJR Am J Roentgenol 142(1):73–78
Lien HH, Stenwig AE, Ous S, Fossa SD (1986) Influence of different criteria for abnormal lymph node size on reliability of computed tomography in patients with non-seminomatous testicular tumor. Acta Radiol Diagn (Stockh) 27(2):199–203
Lien HH, Lindskold L, Stenwig AE, Ous S, Fossa SD (1987) Shape of retroperitoneal lymph nodes at computed tomography does not correlate to metastatic disease in early stage non-seminomatous testicular tumors. Acta Radiol 28(3):271–273
Lien HH, Lindskold L, Fossa SD, Aass N (1988) Computed tomography and conventional radiography in intrathoracic metastases from non-seminomatous testicular tumor. Acta Radiol 29(5):547–549
Lienhard GE, Slot JW, James DE, Mueckler MM (1992) How cells absorb glucose. Sci Am 266(1):86–91
Lowe VJ, Fletcher JW, Gobar L et al (1998) Prospective investigation of positron emission tomography in lung nodules. J Clin Oncol 16(3):1075–1084
MacVicar D (1993) Staging of testicular germ cell tumours. Clin Radiol 47(3):149–158
Marchevsky A, Kaneko M (1992) Surgical pathology of the mediastinum. Raven, New York
Mason MD, Featherstone T, Olliff J, Horwich A (1991) Inguinal and iliac lymph node involvement in germ cell tumours of the testis: implications for radiological investigation and for therapy. Clin Oncol 3(3):147–150
Mazlin ZV, Belenky A, Kunichezky M, Sandbank J, Strauss S (2004) Leydig cell tumors of the testis: gray scale and color Doppler sonographic appearance. J Ultrasound Med 23(7):959–964
Mazzu D, Jeffrey RB, Ralls PW (1995) Lymphoma and leukemia involving the testicles: findings on gray-scale and color Doppler soography. AJR Am J Roentgenol 164(3):645–647
Meanock CI, Ward CS, Williams MP (1988) A potential pitfall of pelvic computed tomography. Br J Radiol 61(727):584–585
Meyer CA, Conces DJ (2002) Imaging of intrathoracic metastases of nonseminomatous germ cell tumors. Chest Surg Clin N Am 12(4):717–738
Moog F, Bangerter M, Kotzerke J, Guhlmann A, Frickhofen N, Reske SN (1998) 18-F-fluorodeoxyglucose-positron emission tomography as a new approach to detect lymphomatous bone marrow. J Clin Oncol 16(2):603–609
Moul JW (1995) Proper staging techniques in testicular cancer patients. Tech Urol 1(3):126–132
Moul JW, Maggio MI, Hardy MR, Hartman DS (1992) Retroaortic left renal vein in testicular cancer patient: potential staging and treatment pitfall. J Urol 147(2):454–456
Muller-Mattheis V, Reinhardt M, Gerharz CD et al (1998) Positron emission tomography with [18 F]-2-fluoro-2-deoxy-D-glucose (18FDG-PET) in diagnosis of retroperitoneal lymph node metastases of testicular tumors. Urologe A 37(6):609–620
Nabi HA, Zubeldia JM (2002) Clinical applications of (18)F-FDG in oncology. J Nucl Med Technol 30(1):3–9; quiz 10–11
Nachtsheim DA, Scheible F, Gosink B (1983) Ultrasonography of testis tumors. J Urol 129(5):978–981
Naidich D, Webb W, Müller N, Krinsky G, Zerhouni E (1998) Computed tomography and magnetic resonance of the thorax, 3rd edn. Lippincott Williams & Wilkins, Philadelphia
Nichols CR (1991) Mediastinal germ cell tumors. Clinical features and biologic correlates. Chest 99(2):472–479
Noone T, Huch-Böni R, Semelka RC (1997) MRI of the abdomen and pelvis. Wiley-Liss, New York
Nuutinen JM, Leskinen S, Elomaa I et al (1997) Detection of residual tumours in postchemotherapy testicular cancer by FDG-PET. Eur J Cancer 33(8):1234–1241
Oyen R, Verellen S, Drochmans A et al (1993) Value of MRI in the diagnosis and staging of testicular tumors. J Belge Radiol 76(2):84–89
Page JE, Prendergast CM, King DM (1990) Retroperitoneal haematoma following orchidectomy: implications for staging computed tomography. Br J Radiol 63(750):490–492
Pick J, Anson BJ (1940) The renal vascular pedicle: an anatomical study of 430 body halves. J Urol 44:411–434
Pollock RE, Doroshow JH, Khayat D (2004) UICC manual of clinical oncology, 8th edn. Wiley, Hoboken
Prokop M, Galanski M. Spiral and Multislice Computed tomography of the Body, Thieme, 2003
Ray B, Hajdu SI, Whitmore WF Jr (1974) Proceedings: distribution of retroperitoneal lymph node metastases in testicular germinal tumors. Cancer 33(2):340–348
Regelink G, Brouwer J, de Bree R et al (2002) Detection of unknown primary tumours and distant metastases in patients with cervical metastases: value of FDG-PET versus conventional modalities. Eur J Nucl Med Mol Imaging 29(8):1024–1030
Rifkin MD, Kurtz AB, Pasto ME, Goldberg BB (1985) Diagnostic capabilities of high-resolution scrotal ultrasonography: prospective evaluation. J Ultrasound Med 4(1):13–19
Rosado-de-Christenson ML, Templeton PA, Moran CA (1992) From the archives of the AFIP. Mediastinal germ cell tumors: radiologic and pathologic correlation. Radiographics 12(5):1013–1030
Royal SA, Callen PW (1979) CT evaluation of anomalies of the inferior vena cava and left renal vein. AJR Am J Roentgenol 132(5):759–763
Rutherford EE, Ferguson JL, Geldart TR, Mead GM, Smart JM, Tung KT (2006) Late relapse of metastatic non-seminomatous testicular germ cell tumours. Clin Radiol 61(11):907–915
Sanchez S, Mahlin M (1986) Simultaneous bilateral testicular tumors, one side clinically occult: detection by ultrasound. J Urol 135:591–592
Schmoll HJ, Souchon R, Krege S et al (2004) European consensus on diagnosis and treatment of germ cell cancer: a report of the European Germ Cell Cancer Consensus Group (EGCCCG). Ann Oncol 15(9):1377–1399
Schoder H, Noy A, Gonen M et al (2005) Intensity of 18fluorodeoxyglucose uptake in positron emission tomography distinguishes between indolent and aggressive non-Hodgkin’s lymphoma. J Clin Oncol 23(21):4643–4651
Scholz M, Zehender M, Thalmann GN, Borner M, Thoni H, Studer UE (2002) Extragonadal retroperitoneal germ cell tumor: evidence of origin in the testis. Ann Oncol 13(1):121–124
Schwerk WB, Schwerk WN, Rodeck G (1987) Testicular tumors: prospective analysis of real-time US patterns and abdominal staging. Radiology 164(2):369–374
See WA, Hoxie L (1993) Chest staging in testis cancer patients: imaging modality selection based upon risk assessment as determined by abdominal computerized tomography scan results. J Urol 150(3):874–878
Seltzer SE, Herman PG, Sagel SS (1984) Differential diagnosis of mediastinal fluid levels visualized on computed tomography. J Comput Assist Tomogr 8(2):244–246
Semelka RC, Helmberger TK (2001) Contrast agents for MR imaging of the liver. Radiology 218(1):27–38
Semelka RC, Schlund JF, Molina PL et al (1996) Malignant liver lesions: comparison of spiral CT arterial portography and MR imaging for diagnostic accuracy, cost, and effect on patient management. J Magn Reson Imaging 6(1):39–43
Shawker TH, Javadpour N, O’Leary T et al (1983) Ultrasound detection of “burned-out” primary testicular tumor in clinically normal testis. J Ultrasound Med 2:477–479
Spaepen K, Stroobants S, Dupont P et al (2002) Early restaging positron emission tomography with (18)F-fluorodeoxyglucose predicts outcome in patients with aggressive non-Hodgkin’s lymphoma. Ann Oncol 13(9):1356–1363
Spermon JR, De Geus-Oei LF, Kiemeney LA, Witjes JA, Oyen WJ (2002) The role of (18)fluoro-2-deoxyglucose positron emission tomography in initial staging and re-staging after chemotherapy for testicular germ cell tumours. BJU Int 89(6):549–556
Stenning S, Parkinson M, Fisher C et al (1998) Postchemotherapy residual masses in germ cell tumor patients. Cancer 83(7):1409–1419
Stephens A, Gonin R, GD H, Einhorn L (1996) Positron emission tomography evaluation of residual radiographic abnormalities in postchemotherapy germ cell tumor patients. J Clin Oncol 14(5):1637–1641
Stephenson AJ, Sheinfeld J (2005) Management of patients with low-stage nonseminomatous germ cell testicular cancer. Curr Treat Options Oncol 6(5):367–377
Stephenson AJ, Bosl GJ, Motzer RJ et al (2005) Retroperitoneal lymph node dissection for nonseminomatous germ cell testicular cancer: impact of patient selection factors on outcome. J Clin Oncol 23(12):2781–2788
Steyerberg E, Keizer H, Fossa S et al (1995) Prediction of residual retroperitoneal mass histology after chemotherapy for metastatic nonseminomatous germ cell tumor: multivariate analysis of individual patient data from Six Study Groups. J Clin Oncol 13(5):1177–1187
Steyerberg E, Keizer H, Sleijfer D et al (2000) Retroperitoneal metastases in testicular cancer: role of CT measurements in decision making for resection after chemotherapy. Radiology 215(2):437–444
Stomper PC, Fung CY, Socinski MA, Jochelson MS, Garnick MB, Richie JP (1987) Detection of retroperitoneal metastases in early-stage nonseminomatous testicular cancer: analysis of different CT criteria. AJR Am J Roentgenol 149(6):1187–1190
Strauss LG (1996) Fluorine-18 deoxyglucose and false-positive results: a major problem in the diagnostics of oncological patients. Eur J Nucl Med 23(10):1409–1415
Suzuki M, Takashima T, Itoh H, Choutoh S, Kawamura I, Watanabe Y (1983) Computed tomography of mediastinal teratomas. J Comput Assist Tomogr 7(1):74–76
Therasse P, Arbuck SG, Eisenhauer EA et al (2000) New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada. J Natl Cancer Inst 92(3):205–216
Thurnher S, Hricak H, Carroll PR, Pobiel RS, Filly RA (1988) Imaging the testis: comparison between MR imaging and US. Radiology 167(3):631–636
Tran T, Grech P, Crofton ME (1989) Computed tomographic staging of testicular tumours: an unexpected source of error. Br J Radiol 62(742):942–944
Tsatalpas P, Beuthien-Baumann B, Kropp J et al (2002) Diagnostic value of 18F-FDG positron emission tomography for detection and treatment control of malignant germ cell tumors. Urol Int 68(3):157–163
Varsamidis K, Varsamidou E, Marvropoulos G (2001) Doppler ultrasonography in testicular tumors presenting with acutescrotal pain. Acta Radiol 42(2):230–233
Vassiliades VG, Foley WD, Alarcon J et al (1991) Hepatic metastases: CT versus MR imaging at 1.5T. Gastrointest Radiol 16(2):159–163
Vesselle HJ, Miraldi FD (1998) FDG PET of the retroperitoneum: normal anatomy, variants, pathologic conditions, and strategies to avoid diagnostic pitfalls. Radiographics 18(4):805–823; discussion 23–24
Warde P, Specht L, Horwich A et al (2002) Prognostic factors for relapse in stage I seminoma managed by surveillance: a pooled analysis. J Clin Oncol 20(22):4448–4452
Webb W, Müller N, Naidich D (2000) High-resolution CT of the lung, 3rd edn. Lippincott Williams & Wilkins, Philadelphia
White PM, Howard GC, Best JJ, Wright AR (1997) The role of computed tomographic examination of the pelvis in the management of testicular germ cell tumours. Clin Radiol 52(2):124–129
White PM, Adamson DJ, Howard GC, Wright AR (1999) Imaging of the thorax in the management of germ cell testicular tumours. Clin Radiol 54(4):207–211
Williams MP, Husband JE, Heron CW (1987) Intrathoracic manifestations of metastatic testicular seminoma: a comparison of chest radiographic and CT findings. AJR Am J Roentgenol 149(3):473–475
Wilson C, Young H, Ott R et al (1995) Imaging metastatic testicular germ cell tumours with F18-FDG positron emission tomography: prospects for detection and management. Eur Nucl Med 22(6):508–513
Wittenberg AF, Tobias T, Rzeszotarski M, Minotti AJ (2006) Sonography of the acute scrotum: the four T’s of testicular imaging. Curr Probl Dign Radiol 35(1):12–21
Wolf G, Aigner RM, Schwarz T, Krippl P, Samonigg H (2003) Diagnosis of a contralateral second testicular carcinoma by F18-FDG PET. Onkologie 26(2):155–157
Wood A, Robson N, Tung K, Mead G (1996) Patterns of supradiaphragmatic metastases in testicular germ cell tumours. Clin Radiol 51(4):273–276
World Health Organization (1979) Handbook for reporting results of cancer treatment. WHO Offset Publication No 48. WHO, Geneva
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2011 Springer-Verlag London Limited
About this chapter
Cite this chapter
De Santis, M., Bachner, M., Lawrentschuk, N., Jack, G.S., Bolton, D.M. (2011). Radiographic Diagnosis and Staging. In: Laguna, M., Albers, P., Bokemeyer, C., Richie, J. (eds) Cancer of the Testis. Springer, London. https://doi.org/10.1007/978-1-84800-370-5_4
Download citation
DOI: https://doi.org/10.1007/978-1-84800-370-5_4
Published:
Publisher Name: Springer, London
Print ISBN: 978-1-84800-369-9
Online ISBN: 978-1-84800-370-5
eBook Packages: MedicineMedicine (R0)