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Organ Regeneration pp 267–278Cite as

Bioengineered Skin Substitutes

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Part of the book series: Methods in Molecular Biology ((MIMB,volume 1001))

Abstract

Bioengineered skin has great potential for use in regenerative medicine for treatment of severe wounds such as burns or chronic ulcers. Genetically modified skin substitutes have also been used as cell-based devices or “live bioreactors” to deliver therapeutics locally or systemically. Finally, these tissue constructs are used as realistic models of human skin for toxicological testing, to speed drug development and replace traditional animal-based tests in a variety of industries. Here we describe a method of generating bioengineered skin based on a natural scaffold, namely, decellularized human dermis and epidermal stem cells.

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Author information

Authors and Affiliations

  1. Department of Chemical and Biological Engineering, University at Buffalo, State University of New York, Amherst, NY, USA

    Pedro Lei, Hui You & Stelios T. Andreadis

Authors
  1. Pedro Lei
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  2. Hui You
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  3. Stelios T. Andreadis
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Editor information

Editors and Affiliations

  1. Tengion, Inc, Westpoint Blvd. 3929, Winston-Salem, 27103, North Carolina, USA

    Joydeep Basu

  2. Zen Bio, Inc., E Hwy 54 3200, Research Triangle Park, 27709, North Carolina, USA

    John W. Ludlow

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Lei, P., You, H., Andreadis, S.T. (2013). Bioengineered Skin Substitutes. In: Basu, J., Ludlow, J. (eds) Organ Regeneration. Methods in Molecular Biology, vol 1001. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-363-3_22

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  • DOI: https://doi.org/10.1007/978-1-62703-363-3_22

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  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-62703-362-6

  • Online ISBN: 978-1-62703-363-3

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