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TRP Channels in Drug Discovery pp 333–350Cite as

Using Diet to Induce Metabolic Disease in Rodents

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Part of the book series: Methods in Pharmacology and Toxicology ((MIPT))

Abstract

Animal models of disease are important tools that allow us to model human conditions and test therapies. Metabolic disease, also called the Metabolic Syndrome (MS), is characterized by obesity, insulin resistance (IR), dyslipidemia and hypertension, the simultaneous occurrence of which increases the risk for developing coronary artery disease, type II diabetes and stroke. While genetic (spontaneous) animal models exist, many researchers prefer diet-induced models of the MS, since it is generally thought that the environment (and particularly the diet) plays a large role in the growing incidence of this disease in humans. This chapter will briefly outline some of the diet-induced approaches for animal models of the MS.

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Authors and Affiliations

  1. Research Diets, Inc., New Brunswick, NJ, USA

    Angela M. Gajda, Michael A. Pellizzon & Matthew R. Ricci

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  1. Angela M. Gajda
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  2. Michael A. Pellizzon
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  3. Matthew R. Ricci
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Correspondence to Angela M. Gajda .

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  1. Transfusion Services, Monmouth Medical Center, Long Branch, New Jersey, USA

    Arpad Szallasi

  2. Department of Physiology, University of Debrecen Medical and Health Science Center, Debrecen, Hungary

    Tamás Bíró

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Gajda, A.M., Pellizzon, M.A., Ricci, M.R. (2012). Using Diet to Induce Metabolic Disease in Rodents. In: Szallasi, A., Bíró, T. (eds) TRP Channels in Drug Discovery. Methods in Pharmacology and Toxicology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-095-3_21

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