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The Spared Nerve Injury Model of Neuropathic Pain

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Pain Research

Part of the book series: Methods in Molecular Biology ((MIMB,volume 851))

Abstract

The spared nerve injury (SNI) model mimics human neuropathic pain related to peripheral nerve injury and is based upon an invasive but simple surgical procedure. Since its first description in 2000, it has displayed a remarkable development. It produces a robust, reliable and long-lasting neuropathic pain-like behaviour (allodynia and hyperalgesia) as well as the possibility of studying both injured and non-injured neuronal populations in the same spinal ganglion. Besides, variants of the SNI model have been developed in rats, mice and neonatal/young rodents, resulting in several possible angles of analysis. Therefore, the purpose of this chapter is to provide a detailed guidance regarding the SNI model and its variants, highlighting its surgical and behavioural testing specificities.

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References

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Author information

Authors and Affiliations

  1. Pain Research Unit, Department of Anesthesiology, University Hospital Center, University of Lausanne, Lausanne, Switzerland

    Marie Pertin, Romain-Daniel Gosselin & Isabelle Decosterd

  2. Department of Cell Biology and Morphology, University of Lausanne, Lausanne, Switzerland

    Marie Pertin, Romain-Daniel Gosselin & Isabelle Decosterd

Authors
  1. Marie Pertin
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  2. Romain-Daniel Gosselin
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  3. Isabelle Decosterd
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Corresponding author

Correspondence to Isabelle Decosterd .

Editor information

Editors and Affiliations

  1. Irvine Medical Center, Dept. Anesthesiology & Pharmacology, University of California, The City Drive S. 101, Orange, 92868, California, USA

    Z. David Luo

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© 2012 Springer Science+Business Media, LLC

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Pertin, M., Gosselin, RD., Decosterd, I. (2012). The Spared Nerve Injury Model of Neuropathic Pain. In: Luo, Z. (eds) Pain Research. Methods in Molecular Biology, vol 851. Humana Press. https://doi.org/10.1007/978-1-61779-561-9_15

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  • DOI: https://doi.org/10.1007/978-1-61779-561-9_15

  • Published:

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-61779-560-2

  • Online ISBN: 978-1-61779-561-9

  • eBook Packages: Springer Protocols

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