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Experimental Models of Anxiety for Drug Discovery and Brain Research

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Mouse Models for Drug Discovery

Part of the book series: Methods in Molecular Biology ((MIMB,volume 602))

Abstract

Animal models have been vital to recent advances in experimental neuroscience, including the modeling of common human brain disorders such as anxiety, depression, and schizophrenia. As mice express robust anxiety-like behaviors when exposed to stressors (e.g., novelty, bright light, or social confrontation), these phenotypes have clear utility in testing the effects of psychotropic drugs. Of specific interest is the extent to which mouse models can be used for the screening of new anxiolytic drugs and verification of their possible applications in humans. To address this problem, the present chapter will review different experimental models of mouse anxiety and discuss their utility for testing anxiolytic and anxiogenic drugs. Detailed protocols will be provided for these paradigms, and possible confounds will be addressed accordingly.

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Acknowledgments

This work was supported by the NARSAD YI Award to AVK and by Stress Physiology and Research Center (SPaRC) of Georgetown University Medical School.

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Authors and Affiliations

  1. Department of Physiology and Biophysics, Georgetown University Medical School, Washington, DC, USA

    Peter C. Hart, Carisa L. Bergner, Amanda N. Smolinsky & Rupert J. Egan

  2. Department of Animal Sciences, Purdue University, West Lafayette, IN, USA

    Brett D. Dufour

  3. Department of Physiology and Biophysics, Stress Physiology and Research Center (SPaRC), Georgetown University Medical School, Washington, DC, USA

    Justin L. LaPorte & Allan V. Kalueff

  4. Department of Pharmacology, Tulane University Medical Center, New Orleans, LA, USA

    Allan V. Kalueff

Authors
  1. Peter C. Hart
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  2. Carisa L. Bergner
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  3. Amanda N. Smolinsky
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  4. Brett D. Dufour
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  5. Rupert J. Egan
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  6. Justin L. LaPorte
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  7. Allan V. Kalueff
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Editor information

Editors and Affiliations

  1. The Jackson Laboratory, Main Street 600, Bar Harbor, 04609, Maine, USA

    Gabriele Proetzel

  2. Jackson Laboratory, Main Street 600, Bar Harbor, 04609, USA

    Michael V. Wiles

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© 2010 Humana Press, a part of Springer Science+Business Media, LLC

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Hart, P.C. et al. (2010). Experimental Models of Anxiety for Drug Discovery and Brain Research. In: Proetzel, G., Wiles, M. (eds) Mouse Models for Drug Discovery. Methods in Molecular Biology, vol 602. Humana Press. https://doi.org/10.1007/978-1-60761-058-8_18

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  • DOI: https://doi.org/10.1007/978-1-60761-058-8_18

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  • Publisher Name: Humana Press

  • Print ISBN: 978-1-60761-057-1

  • Online ISBN: 978-1-60761-058-8

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