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Genetic Cell Ablation

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Mouse Molecular Embryology

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1092))

Abstract

Targeted cell ablation has proven to be a valuable approach to study in vivo cell functions during organogenesis, tissue homeostasis, and regeneration. Over the last two decades, various approaches have been developed to refine the control of cell ablation. In this review, we give an overview of the distinct genetic tools available for targeted cell ablation, with a particular emphasis on their respective specificity.

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Acknowledgments

We thank D. Hipfner and members of the lab for critical reading of the manuscript. This work was supported by the Canadian Institutes for Health Research (CIHR-82880), the Canada Research Chair (to M.K.), and by a postdoctoral fellowship from the Fond de la Recherche en Santé du Québec (to D.G.).

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  1. Laboratory of Genetics and Development, Institut de Recherches Cliniques de Montréal (IRCM), Université de Montréal, Montréal, Québec, Canada

    Damien Grégoire & Marie Kmita

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  1. Damien Grégoire
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  2. Marie Kmita
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  1. Center, National Cancer Institute Frederick Cancer Research & Development, Frederick, Maryland, USA

    Mark Lewandoski

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Grégoire, D., Kmita, M. (2014). Genetic Cell Ablation. In: Lewandoski, M. (eds) Mouse Molecular Embryology. Methods in Molecular Biology, vol 1092. Humana Press, Boston, MA. https://doi.org/10.1007/978-1-60327-292-6_25

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  • DOI: https://doi.org/10.1007/978-1-60327-292-6_25

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