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Controlled Cortical Impact Injury Model

  • Protocol
Animal Models of Acute Neurological Injuries

Part of the book series: Springer Protocols Handbooks ((SPH))

Controlled focal mechanical cortical deformations in rodents have been widely used to model histological, physiological, neurochemical, and functional aspects of human traumatic brain injury. The most common technique termed controlled cortical impact (CCI) utilizes a mechanically actuated piston to control the velocity and depth of cortical impact. In this chapter, we introduce step-by-step procedures to perform a typical CCI in rodents. Details regarding anesthesia, surgery and CCI device operation are included.

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Author information

Authors and Affiliations

  1. Departments of Neurosurgery, Physical Medicine & Rehabilitation, Psychology, Center for Neuroscience, Brain Trauma Research Center, Center for the Neural Basis of Cognition, and the Safar Center for Resuscitation Research, University of Pittsburgh, Pittsburgh, PA, USA

    C. Edward Dixon & Anthony E. Kline

Authors
  1. C. Edward Dixon
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  2. Anthony E. Kline
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Editor information

Editors and Affiliations

  1. Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA

    Jun Chen M.D.

  2. Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN, USA

    Zao C. Xu M.D., Ph.D.

  3. Spinal Cord and Brain Injury Research Group Stark Neurosciences Research Institute Department of Neurological Surgery, Indiana University School of Medicine, Indianapolis, IN, USA

    Xiao-Ming Xu M.D., Ph.D.

  4. Department of Physiology and Pharmacology Department of Neurosurgery Department of Anesthesiology, Loma Linda University Medical School, Loma Linda, CA, USA

    John H. Zhang M.D., Ph.D.

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© 2009 Humana Press, a part of Springer Science + Business Media, LLC

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Dixon, C.E., Kline, A.E. (2009). Controlled Cortical Impact Injury Model. In: Chen, J., Xu, Z.C., Xu, XM., Zhang, J.H. (eds) Animal Models of Acute Neurological Injuries. Springer Protocols Handbooks. Humana Press. https://doi.org/10.1007/978-1-60327-185-1_33

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  • DOI: https://doi.org/10.1007/978-1-60327-185-1_33

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-60327-184-4

  • Online ISBN: 978-1-60327-185-1

  • eBook Packages: Springer Protocols

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