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Brain Spatial Normalization

Indexing Neuroanatomical Databases

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Neuroinformatics

Part of the book series: Methods in Molecular Biology™ ((MIMB,volume 401))

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Summary

Neuroanatomical informatics, a subspecialty of neuroinformatics, focuses on technological solutions to neuroimage database access. Its current main goal is an image-based query system that is able to retrieve imagery based on anatomical location. Here, we describe a set of tools that collectively form such a solution for sectional material and that are available to investigators to use on their own data sets. The system accepts slide images as input and yields a matrix of transformation parameters that map each point on the input image to a standardized 3D brain atlas. In essence, this spatial normalization makes the atlas a spatial indexer from which queries can be issued simply by specifying a location on the reference atlas. Our objective here is to familiarize potential users of the system with the steps required of them as well as steps that take place behind the scene. We detail the capabilities and the limitations of the current implementation and briefly describe the enhancements planned for the near future.

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Authors and Affiliations

  1. Laboratory for Bioimaging and Anatomical Informatics, Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA

    William Bug, Carl Gustafson, Smadar Gefen, Yingli Fan, Louise Bertrand & Jonathan Nissanov

Authors
  1. William Bug
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  2. Carl Gustafson
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  3. Allon Shahar
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  4. Smadar Gefen
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  5. Yingli Fan
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  6. Louise Bertrand
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  7. Jonathan Nissanov
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© 2007 Humana Press Inc.

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Bug, W. et al. (2007). Brain Spatial Normalization. In: Neuroinformatics. Methods in Molecular Biology™, vol 401. Humana Press. https://doi.org/10.1007/978-1-59745-520-6_13

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  • DOI: https://doi.org/10.1007/978-1-59745-520-6_13

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-720-4

  • Online ISBN: 978-1-59745-520-6

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