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Sourcebook of Models for Biomedical Research pp 17–24Cite as

Improved Models for Animal Research

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Abstract

Experimental animal models are critical to understand gene function and human disease. Many rodent models are presently available providing avenues to elucidate gene function and/or to recapitulate specific pathological conditions. To a large extent, successful translation of clinical evidence or analytical data into appropriate mouse models is possible through progress in transgenic or gene deletion technology. Despite these significant improvements, major limitations still exist in manipulating the mouse genome. For this reason and to maximize success, the design and planning of mouse models need good knowledge concerning the requirements and limitations of commonly used strategies and emerging technologies. The purpose of this chapter is to provide a current overview of strategies for manipulating the mouse genome.

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Authors and Affiliations

  1. Max Planck Institute for Medical Research, Heidelberg, Germany

    Rolf Sprengel (Dr. rer.nat.)

  2. Institute of Toxicology/Mouse Genetics, Johannes Gutenberg-Universitat Mainz, Mainz, Germany

    Leonid Eshkind PhD & Ernesto Bockamp Dr. rer.nat.

  3. Institute of Legal Medicine and Rudolf-Boehm Institute of Pharmacology and Toxicology, Center for Toxicology, Leipzig, Germany

    Jan Hengstler MD

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  1. Rolf Sprengel
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  2. Leonid Eshkind PhD
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  4. Ernesto Bockamp Dr. rer.nat.
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Editors and Affiliations

  1. Oregon National Primate Research Center, Beaverton, OR

    P. Michael Conn PhD (Associate Director and Senior Scientist, Professor of Physiology and Pharmacology, Professor of Cell and Developmental Biology) (Associate Director and Senior Scientist, Professor of Physiology and Pharmacology, Professor of Cell and Developmental Biology)

  2. Oregon Health and Science University, Portland, OR

    P. Michael Conn PhD (Associate Director and Senior Scientist, Professor of Physiology and Pharmacology, Professor of Cell and Developmental Biology) (Associate Director and Senior Scientist, Professor of Physiology and Pharmacology, Professor of Cell and Developmental Biology)

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Sprengel, R., Eshkind, L., Hengstler, J., Bockamp, E. (2008). Improved Models for Animal Research. In: Conn, P.M. (eds) Sourcebook of Models for Biomedical Research. Humana Press. https://doi.org/10.1007/978-1-59745-285-4_3

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  • DOI: https://doi.org/10.1007/978-1-59745-285-4_3

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