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Evolution and Origin of Virulence Isolates

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Abstract

Perhaps the most significant benefit of microbial genomic sequences is the knowledge gained on the molecular process of genome evolution in microbes derived from comparative genomic analysis. Genetic variations are the driving forces of evolution. These are generated not only through base substitutions, small deletions and insertions, major DNA rearrangements and deletions, but also through DNA acquisition by horizontal gene transfer. Pathogens are evolved from diverse bacterial species. The molecular mechanisms involved are diverse, and likely affected by the conditions of the microenvironment inhabited by the evolving bacterial species.

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Author information

Authors and Affiliations

  1. Department of Medical Genetics and Microbiology, University of Toronto, Toronto, Ontario, Canada

    Voon Loong Chan PhD

  2. Department of Paediatrics Department of Laboratory Medicine and Pathobiology Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada

    Philip M. Sherman MD, FRCPC

  3. Children’s Research Center, Our Lady’s Hospital for Sick Children, School of Medicine and Medical Science, Dublin, Ireland

    Billy Bourke MD, FRCPI

  4. Conway Institute for Biomolecular and Biomedical Research, Dublin, Ireland

    Billy Bourke MD, FRCPI

Authors
  1. Voon Loong Chan PhD
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  2. Philip M. Sherman MD, FRCPC
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  3. Billy Bourke MD, FRCPI
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Editor information

Editors and Affiliations

  1. Department of Medical Genetics and Microbiology, University of Toronto, Toronto, Ontario, Canada

    Voon L. Chan PhD

  2. Department of Paediatrics Department of Laboratory Medicine and Pathobiology Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada

    Philip M. Sherman MD, FRCPC

  3. Children’s Research Center, Our Lady’s Hospital for Sick Children, School of Medicine and Medical Science, Dublin, Ireland

    Billy Bourke MD, FRCPI

  4. Conway Institute for Biomolecular and Biomedical Research, University College, Dublin, Ireland

    Billy Bourke MD, FRCPI

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© 2006 Humana Press Inc., Totowa, NJ

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Chan, V.L., Sherman, P.M., Bourke, B. (2006). Evolution and Origin of Virulence Isolates. In: Chan, V.L., Sherman, P.M., Bourke, B. (eds) Bacterial Genomes and Infectious Diseases. Humana Press. https://doi.org/10.1007/978-1-59745-152-9_2

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  • DOI: https://doi.org/10.1007/978-1-59745-152-9_2

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-496-8

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