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Neural Stem Cells and the Future Treatment of Neurological Diseases: Raising the Standard

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Neural Stem Cells

Part of the book series: Methods in Molecular Biology™ ((MIMB,volume 438))

Summary

Neural stem and progenitor cells offer great potential for treatment of neurological disorders. Both neurologic and neurological were used in text; the latter was more common. Note changes have been made to match in title and text body. The current strategies of isolation, expansion, and characterization of these cells require in vitro manipulations that can change their intrinsic properties, specifically with the acquisition of chromosomal abnormalities. We have analyzed the rationale of using neural stem cells in neurological disorders, the caveats of current isolation and in vitro culture protocols of neural precursors. Addressing these challenges is crucial for translation of neural stem cell therapy to the clinic.

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Acknowledgments

This work was supported by grants AI043496 and AI058680 from NIAID, and RG3945 from NMSS.

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Authors and Affiliations

  1. Center for Neurologic Diseases, Department of Neurology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA

    Jaime Imitola MD & Samia J. Khoury MD

Authors
  1. Jaime Imitola MD
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  2. Samia J. Khoury MD
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Editor information

Editors and Affiliations

  1. Keck School of Medicine, University of Southern California, 2025 Zonal Ave., Los Angeles, CA 90033, USA

    Leslie P. Weiner

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© 2008 Humana Press, a part of Springer Science+Business Media, LLC

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Imitola, J., Khoury, S.J. (2008). Neural Stem Cells and the Future Treatment of Neurological Diseases: Raising the Standard . In: Weiner, L.P. (eds) Neural Stem Cells. Methods in Molecular Biology™, vol 438. Humana Press. https://doi.org/10.1007/978-1-59745-133-8_2

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  • DOI: https://doi.org/10.1007/978-1-59745-133-8_2

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-846-1

  • Online ISBN: 978-1-59745-133-8

  • eBook Packages: Springer Protocols

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