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Acute Lung Injury

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Principles of Molecular Medicine

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Abstract

The acute respiratory distress syndrome (ARDS)/acute lung injury is a major cause of morbidity and mortality throughout the world. ARDS is an acute syndrome of lung inflammation and increased permeability associated with severe hypoxia and bilateral infiltrates on chest radiographs with no evidence of left heart failure. This chapter reviews the evidence for genetic determinants in acute lung injury and ARDS with a focus on potential candidate gene polymorphism that may be important in the development and outcome of ARDS.

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Selected References

  • Agnese DM, Calvano JE, Hahm SJ, et al. Human toll-like receptor 4 mutations but not CD14 polymorphisms are associated with an increased risk of gram-negative infections. J Infect Dis 2002;186(10): 1522–1525.

    PubMed  CAS  Google Scholar 

  • Arbour NC, Lorenz E, Schutte BC, et al. TLR-4 mutations are associated with endotoxin hyporesponsiveness in humans. Nat Genet 2000;25:187–191.

    PubMed  CAS  Google Scholar 

  • Ashbaugh DG, Bigelow DB, Petty TL, Levine BE. Acute respiratory distress in adults. Lancet 1967;2:319–323.

    PubMed  CAS  Google Scholar 

  • Bell RC, Coalson JJ, Smith JD, et al. Multiple organ system failure andinfection in adult respiratory distress syndrome. Ann Intern Med 1983;99:293–298.

    PubMed  CAS  Google Scholar 

  • Bernard G, Artigas A, Brigham KL, et al., and the Consensus Committee. The American-European Consensus Conference on ARDS. Definitions, mechanisms, relevant outcomes and clinical trial coordinations. Am J Respir Crit Care Med 1994;149(3 Pt 1):818–824.

    PubMed  CAS  Google Scholar 

  • Parsons PE. Mediators and mechanisms of acute lung injury. Clin Chest Med 2000;21(3):467–476.

    PubMed  CAS  Google Scholar 

  • Bersten AD, Hunt T, Nicholas TE, Doyle IR. Elevated plasma surfactant protein-B predicts development of acute respiratory distress syndrome in patients with acute respiratory failure. Am J Respir Crit Care Med 2001;164(4):648–652.

    PubMed  CAS  Google Scholar 

  • Bone RC, Francis PB, Pierce AK. Intravascular coagulation associated with the adult respiratory distress syndrome. Am J Med 1976;61(5):585–589.

    PubMed  CAS  Google Scholar 

  • Border WA, Noble NA. Transforming growth factor β in tissue fibrosis. N Engl J Med 1994;331(19):1286–1292.

    PubMed  CAS  Google Scholar 

  • Brull DJ, Montgomery HE, Sanders J, et al. Interleukin-6 gene-174G>C and-572G>C promoter polymorphisms are strong predictors of plasma interleukin-6 levels after coronary artery bypass surgery. Arterioscler Thromb Vasc Biol 2001;21(9):1458–1463.

    CAS  Google Scholar 

  • Brun-Buisson CJ, Bonnet F, Bergeret S, Lemaire F, Rapin M. Recurrent high-permeability pulmonary edema associated with diabetic ketoaci-dosis. Crit Care Med 1985;13(1):55, 56.

    PubMed  Google Scholar 

  • Cambien F, Poirier O, Lecerf L, et al. Deletion polymorphism in the gene for angiotensin-converting enzyme is a potent risk factor for myocar-dial infarction. Nature 1992;359:641–644.

    PubMed  CAS  Google Scholar 

  • Chevrolet JC, Guelpa G, Schifferli JA. Recurrent adult respiratory distress-like syndrome associated with propylthiouracil therapy. Eur Respir J 1991;4:899–901.

    PubMed  CAS  Google Scholar 

  • Clark JG, Milberg JA, Steinberg KP, Hudson LD. Type III procollagen peptide in the adult respiratory distress syndrome. Association of increased peptide levels in bronchoalveolar lavage fluid with increased risk for death. Ann Intern Med 1995;122(1):17–23.

    PubMed  CAS  Google Scholar 

  • Danis VA, Millington M, Hyland V, Grennan D. Cytokine production by normal human monocytes: Inter-subject variation and relationship to an IL-1 receptor antagonist gene polymorphism. Clin Exp Immunol 1995;99:303–310.

    PubMed  CAS  Google Scholar 

  • Dawson SJ, Wiman B, Hamsten A, Green F, Humphries S, Henney AM. The two allele sequences of a common polymorphism in the promoter of the plasminogen-activator inhibitor 1 gene respond differently to interleukin-1 in HepG2 cells. J Biol Chem 1993;268:10,739–10,745.

    PubMed  CAS  Google Scholar 

  • Deitch EA, Beck SC, Cruz NC, De Maio A. Induction of heat shock gene expression in colonic epithelial cells after incubation with Escherichia coli or endotoxin. Crit Care Med 1995;23:1371–1376.

    PubMed  CAS  Google Scholar 

  • Donnelly TJ, Meade P, Jagels M, et al. Cytokine, complement and endotoxin profiles associated with the development of adult respiratory distress syndrome after severe injury. Crit Care Med 1994;22:768–776.

    PubMed  CAS  Google Scholar 

  • Doyle IR, Bersten AD, Nicholas TE. Surfactant proteins-A and-B are elevated in plasma of patients with acute respiratory failure. Am J Respir Crit Care Med 1997;156(4 Pt 1):1217–1229.

    PubMed  CAS  Google Scholar 

  • Durand P, Bachelet M, Brunet F, et al. Inducibility of the 70 kD heat shock protein in peripheral blood monocytes is decreased in human acute respiratory distress syndrome and recovers over time. Am J Respir Crit Care Med 2000;161(1):286–292.

    PubMed  CAS  Google Scholar 

  • Entzian P, Huckstadt A, Kreipe H, Barth J. Determinations of serum concentrations of type III procollagen peptide in mechanically ventilated patients. Am Rev Respir Dis 1992;142:1079–1082.

    Google Scholar 

  • Farjanel J, Hartmann DJ, Guidet B, Luquel L, Offenstadt G. Four markers of collagen metabolism as possible indicators of disease in the adult respiratory distress syndrome. Am Rev Respir Dis 1993;147:1091–1099.

    PubMed  CAS  Google Scholar 

  • Ferring M, Vincent JL. Is outcome from ARDS related to the severity of respiratory failure? Eur Respir J 1997;10:1297–1300.

    PubMed  CAS  Google Scholar 

  • Fishman D, Faulds G, Jeffery R, et al. The effect of novel polymorphisms in the interleukin-6 gene on IL-6 transcription and plasma IL-6 levels, and an association with systemic-onset juvenile chronic arthritis. J Clin Invest 1998;102:1369–1376.

    PubMed  CAS  Google Scholar 

  • Fourrier F, Chopin C, Goudemand J, et al. Septic shock, multiple organ failure and disseminated intravascular coagulation. Compared patterns of anti-thrombin III, protein C, and protein S deficiencies. Chest 1992;101:816–823.

    PubMed  CAS  Google Scholar 

  • Fourrier F, Chopin C, Wallaert B, Mazurier C, Mangalaboyi J, Durocher A. Compared evolution of plasma fibronectin and angiotensin-converting enzyme levels in septic ARDS. Chest 1985;87:191–195.

    PubMed  CAS  Google Scholar 

  • Fowler AA, Hamman RF, Good JT, et al. Adult respiratory distress syndrome: risk with common predispositions. Ann Intern Med 1983;98:593–597.

    PubMed  CAS  Google Scholar 

  • Fryer AA, Bianco A, Hepple M, Jones PW, Strange RC, Spiteri MA. Polymorphism at the glutathione S-transferase GSTP1 locus: a new marker for bronchial hyperresponsiveness and asthma. Am J Respir Crit Care Med 2000;161:1437–1442.

    PubMed  CAS  Google Scholar 

  • Gallagher PM, Lowe G, Fitzgerald T, et al. Association of IL-10 polymorphism with severity of illness in community acquired pneumonia. Thorax 2003;58:154–156.

    PubMed  CAS  Google Scholar 

  • Gando S, Nakanishi Y, Tedo I. Cytokines and plasminogen activator inhibitor-1 in posttrauma disseminated intravascular coagulation: Relationship to multiple organ dysfunction syndrome. Crit Care Med 1995;23(11):1835–1842.

    PubMed  CAS  Google Scholar 

  • Garred P, Madsen HO, Halberg P, et al. Mannose-binding lectin polymorphisms and susceptibility to infection in systemic lupus erythemato-sus. Arthritis Rheum 1999;42:2145–2152.

    PubMed  CAS  Google Scholar 

  • Garred P, Pressler T, Madsen HO, et al. Association of mannose-binding lectin gene heterogeneity with severity of lung disease and survival in cystic fibrosis. J Clin Invest 1999;104:431–437.

    PubMed  CAS  Google Scholar 

  • Glynn P, Coakley R, Kilgallen I, Murphy N, O’Neill S. Circulating inter-leukin 6 and interleukin 10 in community acquired pneumonia. Thorax 1999;54:51–55.

    PubMed  CAS  Google Scholar 

  • Gong MN, Zhou W, Williams PL, et al.-308GA and TNFB polymorphisms in acute respiratory distress syndrome. Eur Respir J 2005;26:382–389.

    PubMed  CAS  Google Scholar 

  • Gong MN, Zhou W, Xu L, Miller D, Thompson BT, Christiani DC. Polymorphism in the surfactant protein-B gene, gender and the risk of direct pulmonary injury and ARDS. Chest 2004;125:203–211.

    PubMed  CAS  Google Scholar 

  • Gonzolez ER, Cole T, Grimes MM, Fink RA, Fowler AAI. Recurrent ARDS in a 39-year-old woman with migraine headaches. Chest 1998; 114:919–922.

    PubMed  CAS  Google Scholar 

  • Grainger DJ, Heathcote K, Chiano M, et al. Genetic control of the circulating concentration of transforming growth factor type β1. Hum Mol Genet 1999;8(1):93–97.

    PubMed  CAS  Google Scholar 

  • Harding D, Baines PB, Brull D, et al. Severity of meningococcal disease in children and the angiotensin-converting enzyme insertion/deletion polymorphism. Am J Respir Crit Care Med 2002;165:1103–1106.

    PubMed  Google Scholar 

  • Harding D, Dhamrait S, Millar A, et al. Is interleukin-6-174 genotype associated with development of septicemia in preterm infants? Pediatrics 2003;112:800–803.

    PubMed  Google Scholar 

  • Headley AS, Tolley E, Meduri GU. Infections and the inflammatory response in acute respiratory distress syndrome. Chest 1997;111:1306–1321.

    PubMed  CAS  Google Scholar 

  • Hermans PW, Hibberd ML, Booy R, et al. 4G/5G promoter polymorphism in the plasminogen-activator-inhibitor-1 gene and outcome of meningococcal disease. Lancet 1999;354:556–560.

    PubMed  CAS  Google Scholar 

  • Hibberd ML, Sumiya M, Summerfield JA, Booy R, Levin M. Association of variants of the gene for mannose-binding lectin with susceptibility to meningococcal disease. Meningococcal Research Group. Lancet 1999;353:1049–1053.

    PubMed  CAS  Google Scholar 

  • Hierholzer C, Kalff JC, Omert L, et al. Interleukin-6 production in hem-orrhagic shock is accompanied by neutrophil recruitment and lung injury. Am J Physiol 1998;275:L611–L621.

    PubMed  CAS  Google Scholar 

  • Hoffman R, Claypool W, Katyal S, Singh G, Rogers R, Dauber J. Augmentation of rat alveolar macrophage migration by surfactant protein. Am Rev Respir Dis 1987;135:1358–1362.

    PubMed  CAS  Google Scholar 

  • Hudson LD, Milberg JA, Anardi D, Maunder RJ. Clinical risks for development of the acute respiratory distress syndrome. Am J Respir Crit Care Med 1995;151:293–301.

    PubMed  CAS  Google Scholar 

  • Hulkkonen J, Pertovaara M, Antonen J, Pasternack A, Hurme M. Elevated interleukin-6 plasma levels are regulated by the promoter region polymorphism of the IL6 gene in primary Sjogren’s syndrome and correlate with clinical manifestation of the disease. Rheumatology 2001;40:656–661.

    PubMed  CAS  Google Scholar 

  • Hurme M, Santtila S. Il-1 receptor antagonist plasma levels are co-ordinately regulated by both IL-1ra and IL-1 β genes. Eur J Immunol 1998;28:2598–2602.

    PubMed  CAS  Google Scholar 

  • Idell S. Coagulation, fibrinolysis and fibrin deposition in acute lung injury. Crit Care Med 2003;31(Suppl. 4):S213–S220.

    PubMed  CAS  Google Scholar 

  • Iribarren C, Jacobs DR, Jr, Sidney S, Gross MD, Eisner MD. Cigarette smoking, alcohol consumption, and risk of ARDS: a 15-year cohort study in a managed care setting. Chest 2000;117:163–168.

    PubMed  CAS  Google Scholar 

  • Ishii T, Matsuse T, Teramoto S, et al. Glutathione S-transferase P1 (GSTP1) polymorphism in patients with chronic obstructive pulmonary disease. Thorax 1999;54:693–696.

    PubMed  CAS  Google Scholar 

  • Jardin F, Fellahi JL, Beauchet A, Vieillard-Baron A, Loubieres Y, Page B. Improved prognosis of acute respiratory distress syndrome 15 years on. Intensive Care Med 1999;25:936–941.

    PubMed  CAS  Google Scholar 

  • Jia SH, Li Y, Parodo J, Kapus A, Fan L, Rotsein OD, Marshall JC. Pre-B cell colony-enhancing factor inhibits neutrophil apoptosis in experimental inflammation and clinical sepsis. J Clin Invest 2004;113:1318–1327.

    PubMed  CAS  Google Scholar 

  • Johnson J, Brigham KL, Jesmok G, Meyrick B. Morphologic changes in lungs of anesthetized sheep following intravenous infusion of recombi-nant tumor necrosis factor α. Am Rev Respir Dis 1991;144(1): 179–186.

    PubMed  CAS  Google Scholar 

  • Johnson AR, Coalson JJ, Ashton J, Larumbide M, Erdos EG. Neutral endopeptidase in serum samples from patients with adult respiratory distress syndrome. Comparison with angiotensin-converting enzyme. Am Rev Respir Dis 1985;132:1262–1267.

    PubMed  CAS  Google Scholar 

  • Kwiatkowski D, Hill A, Sambou I, et al. TNF concentration in fatal cerebral, non-fatal cerebral and uncomplicated Plasmodium falciparum malaria. Lancet 1990;336:1201–1204.

    PubMed  CAS  Google Scholar 

  • Lane DA, Grant PJ. Role of hemostatic gene polymorphisms in venous and arterial thrombotic disease. Blood 2000;95(5):1517–1532.

    PubMed  CAS  Google Scholar 

  • Lang JD, McArdle PJ, O’Reilly PJ, Matalon S. Oxidant-antioxidant balance in acute lung injury. Chest 2002;122(Suppl. 6):314S–320S.

    PubMed  CAS  Google Scholar 

  • Lin Z, Pearson C, Chinchilli V, et al. Polymorphisms of the human SP-A, SP-B, and SP-D genes: Association of SP-B Thr131Ile with ARDS. Clin Genet 2000;58:181–191.

    PubMed  CAS  Google Scholar 

  • Lindquist S. The heat shock response. Annu Rev Biochem 1986;55: 1151–1191.

    PubMed  CAS  Google Scholar 

  • Lipscombe RJ, Sumiya M, Hill AV, et al. High frequencies in African and non-African populations of independent mutations in the mannose-binding protein gene. Hum Mol Genet 1992;1:709–715 (Erratum in: Hum Mol Genet 1993 2(3):342).

    PubMed  CAS  Google Scholar 

  • Ma P, Chen D, Pan J, Du B. Genomic polymorphism within interleukin-1 family cytokines influences the outcome of septic patients. Crit Care Med 2002;30(5): 1046–1050.

    PubMed  CAS  Google Scholar 

  • Madsen HO, Garred P, Kurtzhals JAL, et al. A new frequent allele is the missing link in the structural polymorphism of the human mannan-binding protein. Immunogenetics 1994;40:37–44.

    PubMed  CAS  Google Scholar 

  • Madsen HO, Garred P, Thiel S, et al. Interplay between promoter and structural gene variants control basal serum levels of mannan-binding protein. J Immunol 1995;155:3013–3020.

    PubMed  CAS  Google Scholar 

  • Majetschak M, Flohe S, Obertacke U, et al. Relation of a TNF gene polym orphism to severe sepsis in trauma patients. Ann Surg 1999;230(2): 207–214.

    PubMed  CAS  Google Scholar 

  • Marshall RP, Webb S, Hill MR, Humphries SE, Laurent GJ. Genetic polymorphisms associated with susceptibility and outcome in ARDS. Chest 2002;121(Suppl 3):68S–69S.

    PubMed  Google Scholar 

  • Marshall RP, Webb S, Bellingan GJ, et al. Angiotensin converting enzyme insertion/deletion polymorphism is associated with susceptibility and outcome in acute respiratory distress syndrome. Am J Respir Crit Care Med 2002;166:646–650.

    PubMed  Google Scholar 

  • Martin C, Papazian L, Payan MJ, et al. Pulmonary fibrosis correlates with outcome in adult respiratory distress syndrome: A study in mechanically ventilated patients. Chest 1995;107(1):196–200.

    PubMed  CAS  Google Scholar 

  • Mattey DL, Hassell AB, Dawes PT, et al. Influence of polymorphism in the manganese superoxide dismutase locus on disease outcome in rheumatoid arthritis: Evidence for interaction with glutathione S-trans-ferase genes. Arthritis Rheum 2000;43(4):859–864.

    PubMed  CAS  Google Scholar 

  • Max M, Pison U, Floros J. Frequency of SP-B and SP-A1 gene polymorphism in the acute respiratory distress syndrome (ARDS). Appl Cardiopulm Pathophysiol 1996;6:111–118.

    Google Scholar 

  • McGue M, Vaupel JW, Holm N, Harvald B. Longevity is moderately heritable in a sample of Danish twins born 1870-1880. J Gerontol 1993;48(6):B237–B244.

    PubMed  CAS  Google Scholar 

  • McKay CJ, Gallagher G, Brooks B, Imrie CW, Baxter JN. Increased monocyte cytokine production in association with systemic complications in acute pancreatitis. Br J Surg 1996;83:919–923.

    PubMed  CAS  Google Scholar 

  • McWilliams JE, Sanderson BJ, Harris EL, Richert-Boe KE, Henner WD. Glutathione S-transferase M1 (GSTM1) deficiency and lung cancer risk. Cancer Epidemiol Biomarkers Prev 1995;4(6):589–594.

    PubMed  CAS  Google Scholar 

  • Meduri GU, Tolley EA, Chrousos GP, Stentz F. Prolonged methylpred-nisolone treatment suppresses systemic inflammation in patients with unresolving acute respiratory distress syndrome: Evidence for inadequate endogenous glucocorticoid secretion and inflammation-induced immune cell resistance to glucocorticoids. Am J Respir Crit Care Med 2002;165:983–991.

    PubMed  Google Scholar 

  • Meduri GU, Headley S, Kohler G, et al. Persistent elevation of inflammatory cytokines predicts a poor outcome in ARDS. Chest 1995;107: 1062–1073.

    PubMed  CAS  Google Scholar 

  • Metnitz PG, Bartens C, Fischer M, et al. Antioxidant status in patients with acute respiratory distress syndrome. Intensive Care Med 1999; 25(2):180–185.

    PubMed  CAS  Google Scholar 

  • Milberg JA, Davis DR, Steinberg KP, Hudson LD. Improved survival of patients with acute respiratory distress syndrome (ARDS): 1983-1993. JAMA 1995;273(4):306–309.

    PubMed  CAS  Google Scholar 

  • Minambres E, Cemborain A, Sanchez-Velasco P, et al. Correlation between transcranial interleukin-6 gradient and outcome in patients with acute brain injury. Crit Care Med 2003;31(3):933–938.

    PubMed  CAS  Google Scholar 

  • Mira JP, Cariou A, Grall F, et al. Association of TNF2, a TNF-α promoter polymorphism, with septic shock susceptibility and mortality. JAMA 1999;282(6):561–568.

    PubMed  CAS  Google Scholar 

  • Montgomery AB, Stager MA, Carrico CH, Hudson LD. Causes of mortality in patients with the adult respiratory distress syndrome. Am Rev Respir Dis 1985;132:485–489.

    PubMed  CAS  Google Scholar 

  • Moss M, Bucher B, Moore FA, Moore EE, Parsons PE. The role of chronic alcohol abuse in the development of acute respiratory distress syndrome in adults. JAMA 1996;275(1):50–54.

    PubMed  CAS  Google Scholar 

  • Moss M, Gillespie MK, Ackerson L, Moore FA, Moore EE, Parsons PE. Endothelial cell activity varies in patients at risk for the adult respiratory distress syndrome. Crit Care Med 1996;24(11): 1782–1786.

    PubMed  CAS  Google Scholar 

  • Moss M, Guidot DM, Steinberg KP, et al. Diabetic patients have a decreased incidence of acute respiratory distress syndrome. Crit Care Med 2000;28(7):2187–2192.

    PubMed  CAS  Google Scholar 

  • LaForce FM. Effect of alveolar lining material on phagocytotic and bactericidal activity of lung macrophages against Staphylococcus aureus. J Lab Clin Med 1976;88:691–699.

    PubMed  CAS  Google Scholar 

  • Lorenz E, Mira JP, Frees KL, Schwartz DA. Relevance of mutations in the TLR-4 receptor in patients with gram-negative septic shock. Arch Intern Med 2002;162:1028–1032.

    PubMed  CAS  Google Scholar 

  • Murray JF, Matthay MA, Luce JM, Flick MR. An expanded definition of the adult respiratory distress syndrome. Am Rev Respir Dis 1989; 138(3);720–723.

    Google Scholar 

  • O’Neill SJ, Lesperance E, Klass DJ. Human lung lavage surfactant enhances staphylococcal phagocytosis by alveolar macrophages. Am Rev Respir Dis 1987;135:1358–1362.

    Google Scholar 

  • Orfanos SE, Armaganidis A, Glynos C, et al. Pulmonary capillary endothelium-bound angiotensin-converting enzyme activity in acute lung injury. Circulation 2000;102(16):2011–2018.

    PubMed  CAS  Google Scholar 

  • Park WY, Goodman RB, Steinberg KP, et al. Cytokine balance in the lungs of patients with acute respiratory distress syndrome. Am J Respir Crit Care Med 2001;164(10 Part 1):1896–1903.

    PubMed  CAS  Google Scholar 

  • Parsons PE, Moore FA, Moore EE, Ikle DN, Henson PM, Worthen GS. Studies on the role of tumor necrosis factor in adult respiratory distresss yndrome. Am Rev Respir Dis 1992;146:694–700.

    PubMed  CAS  Google Scholar 

  • Pittet JF, Mackersie RC, Martin TR, Matthay MA. Biological markers of acute lung injury: Prognostic and pathogenetic significance. Am J Respir Crit Care Med 1997;155(4):1187–1205.

    PubMed  CAS  Google Scholar 

  • Pociot F, Ronningen KS, Nerup J. Polymorphic analysis of the human MHC-linked heat shock protein 70 and HSP 70-HOM genes in insulin dependent diabetes mellitus. Scand J Immunol 1993;38(5):491–495.

    PubMed  CAS  Google Scholar 

  • Prabhakaran P, Ware LB, White KE, Cross MT, Matthay MA, Olman MA. Elevated levels of plasminogen activator inhibitor-1 in pulmonary edema fluid are associated with mortality in acute lung injury. Am J Physiol Lung Cell Mol Physiol 2003;285:L20–L28.

    PubMed  CAS  Google Scholar 

  • Quasney MW, Waterer GW, Dahmer MK, et al. Association between surfactant protein B+1580 polymorphism and the risk of respiratory failure in adults with community-acquired pneumonia. Crit Care Med 2004;32:1115–1119.

    PubMed  CAS  Google Scholar 

  • Quinlan GJ, Lamb NJ, Tilley R, Evans TW, Gutteridge JM. Plasma hypoxanthine levels in ARDS: implications for oxidative stress, morbidity and mortality. Am J Respir Crit Care Med 1997;155(2): 479–484.

    PubMed  CAS  Google Scholar 

  • Read RC, Pullin J, Gregory S, et al. A functional polymorphism of toll-like receptor 4 is not associated with likelihood or severity of meningococcal disease. J Infect Dis 2001;184:640–642.

    PubMed  CAS  Google Scholar 

  • Rinaldo J, Christman JW. Mechanisms and mediators of the adult respiratory distress syndrome. Clin Chest Med 1990;11(4):621–632.

    PubMed  CAS  Google Scholar 

  • Rocco TR Jr, Reinert SE, Cioffi W, Harrington D, Buczko G, Simms HH. A 9-year, single-institution, retrospective review of death rate and prognostic factors in adult respiratory distress syndrome. Ann Surg 2001;233:414–422.

    Google Scholar 

  • Russell JA. Genetics of coagulation factors in acute lung injury. Crit Care Med 2003;21(Suppl 4):S243–S247.

    Google Scholar 

  • Savici D, Katzenstein AL. Diffuse alveolar damage and recurrent respiratory failure: report of 6 cases. Hum Pathol 2001;32(12): 1398–1402.

    PubMed  CAS  Google Scholar 

  • Schaaf BM, Boehmke F, Esnaashari H, et al. Pneumococcal septic shock is associated with interleukin-10-1082 gene promoter polymorphism. Am J Respir Crit Care Med 2003;168(4):476–480.

    PubMed  Google Scholar 

  • Schluter B, Raufhake C, Erren M, et al. Effect of the interleukin-6 promoter polymorphism (-174 G/C) on the incidence and outcome of sepsis. Crit Care Med 2002;30:32–37.

    PubMed  CAS  Google Scholar 

  • Schroder O, Schulte KM, Osterman P, Roher HD, Ekkernkamp A, Schulte KM. Heat shock protein 70 genotypes HSPA1B and HSPA1L influence cytokine concentrations and interfere with outcome after major injury. Crit Care Med 2003;31(1):73–79 (Erratum in: Crit Care Med 2003;31[4]1296).

    PubMed  Google Scholar 

  • Schroeder S, Borger N, Wrigge H, et al. A tumor necrosis factor gene polymorphism influences the inflammatory response after cardiac operation. Ann Thorac Surg 2003;75:534–537.

    PubMed  Google Scholar 

  • Schroeder S, Reck M, Hoeft A, Stuber E. Analysis of two human leukocyte antigen-linked polymorphic heat shock protein 70 genes in patients with severe sepsis. Crit Care Med 1999;27(7): 1265–1270.

    PubMed  CAS  Google Scholar 

  • Shenkar R, Coulson WF, Abraham E. Anti-transforming growth factor-β monoclonal antibodies prevent lung injury in hemorrhaged mice. Am J Respir Cell Mol Biol 1994;11(3):351–357.

    PubMed  CAS  Google Scholar 

  • Sorensen TI, Nielsen GG, Andersen PK, Teasdale TW. Genetic and environmental influences on premature death in adult adoptees. N Engl J Med 1988;318(12):727–732.

    PubMed  CAS  Google Scholar 

  • Spragg RG, Lewis JF, Wurst W, et al. Treatment of acute respiratory distress syndrome with recombinant surfactant protein C surfactant. Am J Respir Crit Care Med 2003;167(11):1562–1566.

    PubMed  Google Scholar 

  • Steinberg KP, McHugh LG, Hudson LD. Causes of mortality in patients with adult respiratory distress syndrome. Am Rev Respir Dis 1993;147:A347.

    Google Scholar 

  • Strange RC, Spiteri MA, Ramachandran S, Fryer AA. Glutathione-S-transferase family of enyzmes. Mutat Res 2001;482:21–26.

    PubMed  CAS  Google Scholar 

  • Stuber F, Petersen M, Bokelmann F, Schade U. A genomic polymorphism within the tumor necrosis factor locus influences plasma tumor necrosis factor-α concentrations and outcome of patients with severe sepsis. Crit Care Med 1996;24(3):381–384.

    PubMed  CAS  Google Scholar 

  • Stuber F, Udalova IA, Book M, et al.-308 Tumor necrosis factor (TNF) polymorphism is not associated with survival in severe sepsis and is unrelated to lipopolysaccharide inducibility of the human TNF promoter. J Inflamm 1996;46:42–50.

    CAS  Google Scholar 

  • Suarez M, Krieger BP. Bronchoalveolar lavage in recurrent aspirin-induced adult respiratory distress syndrome. Chest 1986;90:452,453.

    Google Scholar 

  • Summerfield JA, Sumiya M, Levin M, Turner MW. Association of mutations in mannose binding protein gene with childhood infection in consecutive infection in consecutive hospital series. BMJ 1997;314: 1229–1232.

    PubMed  CAS  Google Scholar 

  • Suzuki H, Matsui Y, Kashiwagi H. Interleukin-1 receptor antagonist gene polymorphism in Japanese patients with systemic lupus erythemato-sus. Arthritis Rheum 1997;40:389,390.

    Google Scholar 

  • Tang GJ, Huang SL, Yien HW, et al. Tumor necrosis factor gene polymorphism and septic shock in surgical infection. Crit Care Med 2003;28:1733–1736.

    Google Scholar 

  • Turner DM, Williams DM, Sankaran D, Lazarus M, Sinnott PJ, Hutchinson IV. An investigation of polymorphism in interleukin-10 gene promoter. Eur J Immunogenet 1997;24(1):1–8.

    PubMed  CAS  Google Scholar 

  • Van der Poll Y, de Waal Malefyt R, Coyle SM, Lowry SF. Anti-inflammatory cytokine response during clinical sepsis and experimental endo-toxemia: sequential measurements of plasma soluble interleukin-1 receptor type II, IL-10, and IL-13. J Infect Dis 1997;175:118–122.

    PubMed  Google Scholar 

  • Vervloet MG, Thijs LG, Hack CE. Derangements of coagulation and fib-rinolysis in critically ill patients with sepsis and septic shock. Semin Thromb Hemost 1998;24(1):33–43.

    PubMed  CAS  Google Scholar 

  • Villar J, Edelson JD, Post M, Mullen JB, Slutsky AS. Induction of heat stress proteins is associated with decreased mortality in an animal model of acute lung injury. Am Rev Respir Dis 1993;147:177–181.

    PubMed  CAS  Google Scholar 

  • Villar J, Ribeiro SP, Mullen JB, Kuliszewski M, Post M, Slutsky AS. Induction of the heat shock response reduces mortality rate and organ damage in a sepsis-induced acute lung injury model. Crit Care Med 1994;22:914–921.

    PubMed  CAS  Google Scholar 

  • Ware LB, Matthay MA. The acute respiratory distress syndrome. N Engl J Med 2000;342(18):1334–1349.

    PubMed  CAS  Google Scholar 

  • Waterer GW, Quasney MW, Cantor RM, Wunderink RG. Septic shock and respiratory failure in community-acquired pneumonia have different TNF polymorphism associations. Am J Respir Crit Care Med 2001;163(7):1599–1604.

    PubMed  CAS  Google Scholar 

  • Westendorp RGJ, Hottenga JJ, Slagboom PE. Variation in plasminogen-activator-inhibitor-1 gene and risk of meningococcal septic shock. Lancet 1999;354:561–563.

    PubMed  CAS  Google Scholar 

  • Westendorp RG, Langermans JA, Huizinga TW, Verweij CL, Sturk A. Genetic influence on cytokine production and fatal meningococcal disease. Lancet 1997;329:170–173.

    Google Scholar 

  • Westendorp R, Langermans J, Huizinga T, et al. Genetic influence on cytokine production and fatal meningococcal disease. Lancet 1997;349:170–173.

    PubMed  CAS  Google Scholar 

  • Wheeler AP, Bernard GR. Treating patients with severe sepsis. N Engl J Med 1999;340(3):207–214.

    PubMed  CAS  Google Scholar 

  • Yang IA, Seeney SL, Wolter JM, et al. Mannose-binding lectin gene polymorphism predicts hospital admissions for COPD infections. Genes Immun 2003;4(4):269–274.

    PubMed  CAS  Google Scholar 

  • Ye SQ, Simon BA, Maloney JP, et al. Pre-B-cell colony-enhancing factor as a potential novel biomarker in acute lung injury. Am J Respir Crit Care Med 2005;171:361–370.

    PubMed  Google Scholar 

  • Yost DA, Michalowski E. Adult respiratory distress syndrome complicating recurrent antepartum pyelonephritis. J Fam Pract 1990;31:81,82.

    Google Scholar 

  • Yoshida K, Ishigami T, Nakazawa I, et al. Association of essential hypertension in elderly Japanese with I/D polymorphism of the angiotensin-converting enzyme (ACE) gene. J Hum Genet 2000;45(5):294–298.

    PubMed  CAS  Google Scholar 

  • Zhang H, Slutsky AS, Vincent JL. Oxygen free radicals in ARDS, septic shock and organ dysfunction. Intensive Care Med 2000;26:474–476.

    PubMed  CAS  Google Scholar 

  • Zilberberg MD, Epstein SK. Acute lung injury in the medical ICU: Comorbid conditions, age, etiology and hospital outcome. Am J Respir Crit Care Med 1998;157(4 Pt 1):1159–1164.

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Pulmonary and Critical Care Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Environmental Health Department, Harvard School of Public Health, Boston, MA

    David C. Christiani

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  1. Michelle Ng Gong
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  2. David C. Christiani
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Editors and Affiliations

  1. Department of Medicine, Division of Cardiology Carolina Cardiovascular Biology Center, University of North Carolina School of Medicine, Chapel Hill, NC

    Marschall S. Runge MD, PhD  & Cam Patterson MD  & 

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© 2006 Humana Press Inc.

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Gong, M.N., Christiani, D.C. (2006). Acute Lung Injury. In: Runge, M.S., Patterson, C. (eds) Principles of Molecular Medicine. Humana Press. https://doi.org/10.1007/978-1-59259-963-9_25

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  • DOI: https://doi.org/10.1007/978-1-59259-963-9_25

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-202-5

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