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The Use of Saporin Conjugates to Dissect Neurons Responsible for Sleep and Wakefulness

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Book cover Molecular Neurosurgery With Targeted Toxins

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Abstract

Virtually all organisms manifest regular periods of behavioral quiescence and activity. In mammals and birds, these periods have evolved into regular episodes of wakefulness and sleep. The sleep period itself has further differentiated into two distinct states, slow wave sleep (SWS) and rapid eye movement (REM) sleep. In humans, SWS has further differentiated into four distinct stages, each identified by a specific pattern on the electroencephalogram (EEG). REM sleep is very similar to wakefulness in many ways; the main difference is that there is behavioral quiescence during REM sleep. For this reason, REM sleep is often referred to as paradoxical sleep.

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Authors and Affiliations

  1. Department of Neurology, Harvard Medical School and Veterans Administration Medical Center, West Roxbury, MA

    Carlos Blanco-Centurion, Dmitry Gerashchenko, Eric Murillo-Rodriguez, Frank Desarnaud & Priyattam J. Shiromani PhD

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  1. Carlos Blanco-Centurion
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  2. Dmitry Gerashchenko
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  3. Eric Murillo-Rodriguez
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  4. Frank Desarnaud
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  5. Priyattam J. Shiromani PhD
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Editors and Affiliations

  1. Department of Neurology, Vanderbilt University School of Medicine, Nashville, TN

    Ronald G. Wiley MD, PhD

  2. Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN

    Ronald G. Wiley MD, PhD

  3. Neurology Service, Veterans Affairs Tennessee Valley Healthcare System, Nashville, TN

    Ronald G. Wiley MD, PhD

  4. Advanced Targeting Systems, San Diego, CA

    Douglas A. Lappi PhD (President and Chief Scientific Officer) (President and Chief Scientific Officer)

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Blanco-Centurion, C., Gerashchenko, D., Murillo-Rodriguez, E., Desarnaud, F., Shiromani, P.J. (2005). The Use of Saporin Conjugates to Dissect Neurons Responsible for Sleep and Wakefulness. In: Wiley, R.G., Lappi, D.A. (eds) Molecular Neurosurgery With Targeted Toxins. Humana Press. https://doi.org/10.1007/978-1-59259-896-0_11

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  • DOI: https://doi.org/10.1007/978-1-59259-896-0_11

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