Abstract
Vector control has significantly reduced malaria morbidity in many regions of the world where the disease was endemic and is now moving toward malaria elimination. Among the tools available for vector control, the use of long-lasting insecticidal bed nets (LLINs) and indoor residual spraying (IRS) has proved most effective. However, Anopheles mosquitoes are becoming increasingly resistant to insecticides. In this chapter, we describe the main aspects of vector control—with a particular focus on insecticidal products commonly used in vector control as well as on mechanisms of insecticide resistance. We also discuss the impact of insecticide resistance on malaria transmission.
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References
World Health Organization (1992) Ministerial conference on malaria, Amsterdam, The Netherlands 26–27 October. World Health Organization, Geneva
Roberts L (2002) Mosquitoes and disease. Science 298:82–83
Esvelt K (2016) Gene editing can drive science to openness. Nature 534:153
Baldini F, Segata N, Pompon J et al (2014) Evidence of natural Wolbachia infections in field populations of Anopheles gambiae. Nat Commun 5:3985
World Health Organization (1997) Vector control: methods for use by individuals and communities. World Health Organization, Geneva
Mnzava AP, Knox TB, Temu EA (2015) Implementation of the global plan for insecticide resistance management in malaria vectors: progress, challenges and the way forward. Malar J 14:173
Chanda E, Mzilahowa T, Chipwanya J et al (2016) Scale-up of integrated malaria vector control: lessons from Malawi. Bull World Health Organ 94:475–480
World Health Organization (2013) Larval source management – a supplementary measure for malaria vector control. An operational manual. World Health Organization, Geneva
Brownbridge M, Margalit J (1986) New Bacillus thuringiensis strains isolated in Israel are highly toxic to mosquito larvae. J Invertebr Pathol 48:216–222
World Health Organization (2015) Indoor residual spraying: An operational manual for IRS for malaria transmission, control and elimination, 2nd edn. World Health Organization, Geneva
Russell TL, Govella NJ, Azizi S et al (2011) Increased proportions of outdoor feeding among residual malaria vector populations following increased use of insecticide-treated nets in rural Tanzania. Malar J 10:80
Sougoufara S, Diedhiou SM, Doucoure S et al (2014) Biting by Anopheles funestus in broad daylight after use of long-lasting insecticidal nets: a new challenge to malaria elimination. Malar J 13:125
WHO Pesticide Evaluation Scheme (2013) WHO recommended insecticides for indoor residual spraying against malaria vectors. World Health Organization, Geneva
Hamon J, Garrett-Jones C (1963) Resistance to insecticides in the major malaria vectors and its operational importance. Bull World Health Organ 28:1–24
Darriet F, Robert V, Vien NT et al (1984) Evaluation de l’efficacité sur les vecteurs du paludisme de la Permethrine en imprégnation sur des moustiquaires intactes et trouées. Organisation mondiale de la Santé, Genève
World Health Organization (2001) Spécifications concernant les tulles pour moustiquaires. Rapport de consultation informelle. World Health Organization, Geneva
Wilson AL, Dhiman RC, Kitron U et al (2014) Benefit of insecticide-treated nets, curtains and screening on vector borne diseases, excluding malaria: a systematic review and meta-analysis. PLoS Negl Trop Dis 8:e3228
World Health Organization (2017) Achieving and maintaining universal coverage with long-lasting insecticidal nets for malaria control. World Health Organization, Geneva
Ranson H, Lissenden N (2016) Insecticide resistance in African Anopheles mosquitoes: a worsening situation that needs urgent action to maintain malaria control. Trends Parasitol 32:187–196
Martinez-Torres D, Chandre F, Williamson MS et al (1998) Molecular characterization of pyrethroid knockdown resistance (kdr) in the major malaria vector Anopheles gambiae s.s. Insect Mol Biol 7:179–184
WHO Pesticide Evaluation Scheme (2016) Geneva: World Health Organization
Beerntsen BT, James AA, Christensen BM (2000) Genetics of mosquito vector competence. Microbiol Mol Biol Rev 64:115–137
Curtis CF, Pates HV, Takken W et al (1999) Biological problems with the replacement of a vector population by Plasmodium-refractory mosquitoes. Parassitologia 41:479–481
Boete C (2005) Malaria parasites in mosquitoes: laboratory models, evolutionary temptation and the real world. Trends Parasitol 21:445–447
White BJ, Hahn MW, Pombi M et al (2007) Localization of candidate regions maintaining a common polymorphic inversion (2La) in Anopheles gambiae. PLoS Genet 3:e217
Walker T, Moreira LA (2011) Can Wolbachia be used to control malaria? Mem Inst Oswaldo Cruz 106:212–217
Raymond-Delpech V, Matsuda K, Sattelle BM, Rauh JJ, Sattelle DB (2005) Ion channels: molecular targets of neuroactive insecticides. Invert Neurosci 5(3-4):119–133.
Asidi AN, N’Guessan R, Hutchinson RA et al (2004) Experimental hut comparisons of nets treated with carbamate or pyrethroid insecticides, washed or unwashed, against pyrethroid-resistant mosquitoes. Med Vet Entomol 18:134–140
Hemingway J, Ranson H, Magill A et al (2016) Averting a malaria disaster: will insecticide resistance derail malaria control? Lancet 387:1785–1788
Who expert citation (WHO Expert Committee on Insecticides & World Health Organization. (1957). Expert Committee on Insecticides: seventh report [of a meeting held in Geneva from 10 to 17 July 1956]. World Health Organization. http://www.who.int/iris/handle/10665/40380)
Harrison CM (1952) The resistance of insects to insecticides. Trans R Soc Trop Med Hyg 46:255–263
Berticat C, Duron O, Heyse D et al (2004) Insecticide resistance genes confer a predation cost on mosquitoes, Culex pipiens. Genet Res 83:189–196
Ffrench-Constant RH, Bass C (2017) Does resistance really carry a fitness cost? Curr Opin Insect Sci 21:39–46
Lockwood JA, Sparks TC, Story RN (1984) Evolution of insect resistance to insecticides: a reevaluation of the roles of physiology and behaviour. Bull Entomol Soc Am 30:41–51
Davidson G (1953) Experiments on the effect of residual insecticides in houses against Anopheles gambiae and A. funestus. Bull Entomol Res 44:231–245
Green CA, Gass RF, Munstermann LE et al (1990) Population-genetic evidence for two species in Anopheles minimus in Thailand. Med Vet Entomol 4:25–34
Chareonviriyaphap T, Bangs MJ, Suwonkerd W et al (2013) Review of insecticide resistance and behavioral avoidance of vectors of human diseases in Thailand. Parasit Vectors 6:280
Rostant WG, Bowyer J, Coupland J et al (2017) Pleiotropic effects of DDT resistance on male size and behaviour. Behav Genet 47:449–458
Yahouedo GA, Chandre F, Rossignol M et al (2017) Contributions of cuticle permeability and enzyme detoxification to pyrethroid resistance in the major malaria vector Anopheles gambiae. Sci Rep 7:1109
Koganemaru R, Miller DM, Adelman ZN (2013) Robust cuticular penetration resistance in the common bed bug (Cimex lectularius L.) correlates with increased steady-state transcript levels of CPR-type cuticle protein genes. Pestic Biochem Physiol 106:190–197
Wood O, Hanrahan S, Coetzee M et al (2010) Cuticle thickening associated with pyrethroid resistance in the major malaria vector Anopheles funestus. Parasit Vectors 3:67
Balabanidou V, Kampouraki A, MacLean M et al (2016) Cytochrome P450 associated with insecticide resistance catalyzes cuticular hydrocarbon production in Anopheles gambiae. Proc Natl Acad Sci U S A 113:9268–9273
Brogdon WG, McAllister JC, Vulule J (1997) Heme peroxidase activity measured in single mosquitoes identifies individuals expressing an elevated oxidase for insecticide resistance. J Am Mosq Control Assoc 13:233–237
Hemingway J, Brogdon WG (1998) Techniques to detect insecticide resistance mechanisms (Field and laboratory manual). In: Document WHO/CDS/CPC/MAL/986. World Health Organization, Geneva
Ole Sangba ML, Sidick A, Govoetchan R et al (2017) Evidence of multiple insecticide resistance mechanisms in Anopheles gambiae populations in Bangui, Central African Republic. Parasit Vectors 10:23
Ranson H, N’Guessan R, Lines J et al (2011) Pyrethroid resistance in African anopheline mosquitoes: what are the implications for malaria control? Trends Parasitol 27:91–98
Franciosa H, Bergé JB (1995) Glutathione S-transferases in housefly (Musca domestica): Location of GST-1 and GST-2 families. Insect Biochem Molec Biol 25:311–317
Brogdon WG, McAllister JC (1998) Insecticide resistance and vector control. Emerg Infect Dis 4:605–613
Dahan-Moss YL, Koekemoer LL (2016) Analysis of esterase enzyme activity in adults of the major malaria vector Anopheles funestus. Parasite Vectors 9:110
Kim YH, Lee SH (2013) Which acetylcholinesterase functions as the main catalytic enzyme in the Class Insecta? Insect Biochem Mol Biol 43:47–53
Pitman RM (1971) Transmitter substances in insects: A review. Comp Gen Pharmacol 2:347–371
Mutero A, Pralavorio M, Bride JM et al (1994) Resistance-associated point mutations in insecticide-insensitive acetylcholinesterase. Proc Natl Acad Sci U S A 91:5922–5926
Weill M, Lutfalla G, Mogensen K et al (2003) Comparative genomics: Insecticide resistance in mosquito vectors. Nature 423:136–137
Aizoun N, Aikpon R, Gnanguenon V et al (2013) Status of organophosphate and carbamate resistance in Anopheles gambiae sensu lato from the south and north Benin, West Africa. Parasit Vectors 6:274
Marban E, Yamagishi T, Tomaselli GF (1998) Structure and function of voltage-gated sodium channels. J Physiol 508:647–657
Dong K (1997) A single amino acid change in the para sodium channel protein is associated with knockdown-resistance (kdr) to pyrethroid insecticides in German cockroach. Insect Biochem Mol Biol 27:93–100
Dong K (2007) Insect sodium channels and insecticide resistance. Invertebr Neurosci 7:17–30
Hemingway J, Boddington R, Harris J et al (1989) Mechanisms of insecticide resistance in Aedes aegypti (L.) (Diptera: Culicidae) from Puerto Rico. Bulletin of Entomology Research 79:123–130
Vatandoost H, Mccaffery AR, Townson H (1996) Anopheles electrophysiological investigation of target site insensitivity mechanisms in permethrin-resistant and susceptible strain of Anopheles stephensi. Trans R Soc Trop Med Hyg 90:216
Chandre F, Darriet F, Darder M et al (1998) Pyrethroid resistance in Culex quinquefasciatus from west Africa. Med Vet Entomol 12:359–366
Ranson H, Jensen B, Vulule JM et al (2000) Identification of a point mutation in the voltage-gated sodium channel gene of Kenyan Anopheles gambiae associated with resistance to DDT and pyrethroids. Insect Mol Biol 9:491–497
Djegbe I, Boussari O, Sidick A (2011) Dynamics of insecticide resistance in malaria vectors in Benin: first evidence of the presence of L1014S kdr mutation in Anopheles gambiae from West Africa. Malar J 10:261
Ndiath MO, Cailleau A, Orlandi-Pradines E et al (2015) Emerging knock-down resistance in Anopheles arabiensis populations of Dakar, Senegal: first evidence of a high prevalence of kdr-e mutation in West African urban area. Malar J 14:364
Ikeda T, Nagata K, Shono T et al (1998) Dieldrin and picrotoxinin modulation of GABA(A) receptor single channels. Neurorepor 9:3189–3195
Zhao X, Salgado VL, Yeh JZ et al (2003) Differential actions of fipronil and dieldrin insecticides on GABA-gated chloride channels in cockroach neurons. J Pharmacol Exp Ther 306:914–924
World Health Organization (2016) World Malaria Report 2016. Document WHO/HTM/GMP/2016. World Health Organization, Geneva, p 2
Feachem R, Sabot O (2008) A new global malaria eradication strategy. Lancet 371:1633–1635
Greenwood BM (2008) Control to elimination: implications for malaria research. Trends Parasitol 24:449–454
Roberts R, Enserink M (2007) Malaria. Did they really say ... eradication? Science 318:1544–1545
Russell TL, Beebe NW, Cooper RD et al (2013) Successful malaria elimination strategies require interventions that target changing vector behaviours. Malar J 12:56
Sokhna C, Ndiath MO, Rogier C (2013) The changes in mosquito vector behaviour and the emerging resistance to insecticides will challenge the decline of malaria. Clin Microbiol Infect 19:902–907
Corbel V, Akogbeto M, Damien GB et al (2012) Combination of malaria vector control interventions in pyrethroid resistance area in Benin: a cluster randomised controlled trial. Lancet Infect Dis 12:617–626
Trape JF, Tall A, Diagne N et al (2011) Malaria morbidity and pyrethroid resistance after the introduction of insecticide-treated bednets and artemisinin-based combination therapies: a longitudinal study. Lancet Infect Dis 11:925–932
Killeen GF (2014) Characterizing, controlling and eliminating residual malaria transmission. Malar J 13:330
Russell TL, Lwetoijera DW, Maliti D et al (2010) Impact of promoting longer-lasting insecticide treatment of bed nets upon malaria transmission in a rural Tanzanian setting with pre-existing high coverage of untreated nets. Malar J 9:187
Reddy MR, Overgaard HJ, Abaga S et al (2011) Outdoor host seeking behaviour of Anopheles gambiae mosquitoes following initiation of malaria vector control on Bioko Island, Equatorial Guinea. Malar J 10:184
Trung HD, Bortel WV, Sochantha T et al (2005) Behavioural heterogeneity of Anopheles species in ecologically different localities in Southeast Asia: a challenge for vector control. Tropical Med Int Health 10:251–262
Moiroux N, Gomez MB, Pennetier C et al (2012) Changes in Anopheles funestus biting behavior following universal coverage of long-lasting insecticidal nets in Benin. J Infect Dis 206:1622–1629
Durnez L, Coosemans M (2014) Residual transmission of malaria: an old issue for new approaches. In: Manguin SE (ed) Anopheles mosquitoes – new insights into malaria vectors. ISBN: 978-953-51-1188-7 InTech
Kelly-Hope L, Ranson H, Hemingway J (2008) Lessons from the past: managing insecticide resistance in malaria control and eradication programmes. Lancet Infect Dis 8:387–389
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Ndiath, M.O. (2019). Insecticides and Insecticide Resistance. In: Ariey, F., Gay, F., Ménard, R. (eds) Malaria Control and Elimination. Methods in Molecular Biology, vol 2013. Humana, New York, NY. https://doi.org/10.1007/978-1-4939-9550-9_18
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DOI: https://doi.org/10.1007/978-1-4939-9550-9_18
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