Abstract
Brief stereotaxic insertion and removal of a microneedle into the hippocampus of mice result in stimulation of hippocampal neurogenesis. This approach has been previously applied to a mouse model of Alzheimer’s disease (Song et al., Cell Transplant 25:1853–1861, 2016). Further studies of fundamental cellular mechanisms of the brain’s response to micro-injury will be useful for investigation of potential neuroprotective and deleterious effects of targeted microlesions and deep brain stimulation in neurodegenerative diseases.
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Supported in part by VA Merit Grant and Ellis Research Fund.
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Song, S., Kong, X., Sanchez-Ramos, J. (2019). Method for Stimulation of Hippocampal Neurogenesis by Transient Microneedle Insertion. In: Daadi, M. (eds) Neural Stem Cells. Methods in Molecular Biology, vol 1919. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-9007-8_18
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DOI: https://doi.org/10.1007/978-1-4939-9007-8_18
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