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Targeted Single Gene Mutation in Esophageal Adenocarcinoma

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Esophageal Adenocarcinoma

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1756))

Abstract

Esophageal adenocarcinoma is heterogeneous and studies have reviewed many important mutations that contribute to the pathogenesis of the cancer. These discoveries have helped paved the way into identifying new gene markers or gene targets to develop novel molecular directed therapy for better patient outcomes in esophageal adenocarcinoma. Despite the recent bloom in next-generation sequencing, Sanger sequencing still represents the gold standard method for the study of the driver genes in esophageal adenocarcinoma. This chapter focuses on the sequencing techniques in identification of single gene mutations.

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Authors and Affiliations

  1. Cancer Molecular Pathology of School of Medicine, Griffith University, Gold Coast, Australia

    Katherine T. W. Lee, Vinod Gopalan & Alfred K. Lam

  2. Genomics Research Centre, School of Biomedical Science, Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, QLD, Australia

    Robert A. Smith

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  1. Katherine T. W. Lee
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  2. Robert A. Smith
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  3. Vinod Gopalan
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  4. Alfred K. Lam
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Correspondence to Alfred K. Lam .

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  1. Cancer Molecular Pathology of School of Medicine, Griffith University, Gold Coast, Australia

    Alfred K. Lam

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Lee, K.T.W., Smith, R.A., Gopalan, V., Lam, A.K. (2018). Targeted Single Gene Mutation in Esophageal Adenocarcinoma. In: Lam, A. (eds) Esophageal Adenocarcinoma. Methods in Molecular Biology, vol 1756. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-7734-5_19

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  • DOI: https://doi.org/10.1007/978-1-4939-7734-5_19

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-7733-8

  • Online ISBN: 978-1-4939-7734-5

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