Skip to main content
SpringerLink
Log in

Nanoplasmonic Biosensor Using Localized Surface Plasmon Resonance Spectroscopy for Biochemical Detection

  • Protocol
  • First Online:
Biosensors and Biodetection

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1571))

Abstract

Localized surface plasmon resonance (LSPR) associated with metal nanostructures has developed into a highly useful sensor technique. Optical LSPR spectroscopy of nanostructures often shows sharp absorption and scattering peaks, which can be used to probe several bio-molecular interactions. Here, we report nanoplasmonic biosensors using LSPR on nanocup arrays (nanoCA) to recognize bio-molecular binding for biochemical detection. These sensors can be modified to quantify binding of small molecules to proteins for odorant and explosive detections. Electrochemical LSPR biosensors can also be designed by coupling electrochemistry and LSPR spectroscopy measurements. Multiple sensing information can be obtained and electrochemical LSPR property can be investigated for biosensors. In some applications, the electrochemical LSPR biosensor can be used to quantify immunoreactions and enzymatic activity. The biosensors exhibit better performance than those of conventional optical LSPR measurements. With multi-transducers, the nanoplasmonic biosensor can provide a promising approach for bio-detection in environmental monitoring, healthcare diagnostics, and food quality control.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Protocol
USD 49.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 159.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Homola J (2008) Surface plasmon resonance sensors for detection of chemical and biological species. Chem Rev 108:462–493

    Article  CAS  Google Scholar 

  2. Vollmer F, Arnold S (2008) Whispering-gallery-mode biosensing: label-free detection down to single molecules. Nat Methods 5:591–596

    Article  CAS  Google Scholar 

  3. Nair RV, Vijaya R (2010) Photonic crystal sensors: an overview. Prog Quant Electron 34:89–134

    Article  CAS  Google Scholar 

  4. Saha K, Agasti SS, Kim C et al (2012) Gold nanoparticles in chemical and biological sensing. Chem Rev 112:2739–2779

    Article  CAS  Google Scholar 

  5. Willets KA, Van Duyne RP (2007) Localized surface plasmon resonance spectroscopy and sensing. Annu Rev Phys Chem 58:267–297

    Article  CAS  Google Scholar 

  6. Mayer KM, Hafner JH (2011) Localized surface plasmon resonance sensors. Chem Rev 111:3828–3857

    Article  CAS  Google Scholar 

  7. Gao HW, Henzie J, Odom TW (2006) Direct evidence for surface plasmon-mediated enhanced light transmission through metallic nanohole arrays. Nano Lett 6:2104–2108

    Article  CAS  Google Scholar 

  8. Anker JN, Hall WP, Lyandres O et al (2008) Biosensing with plasmonic nanosensors. Nat Mater 7:442–453

    Article  CAS  Google Scholar 

  9. Stewart ME, Anderton CR, Thompson LB et al (2008) Nanostructured plasmonic sensors. Chem Rev 108:494–521

    Article  CAS  Google Scholar 

  10. Cao J, Sun T, Grattan KT (2014) Gold nanorod-based localized surface plasmon resonance biosensors: a review. Sens Actuators B 195:332–351

    Article  CAS  Google Scholar 

  11. Cheng XR, Wallace GQ, Lagugné-Labarthet F et al (2015) Au nanostructured surfaces for electrochemical and localized surface plasmon resonance-based monitoring of α-synuclein–small molecule interactions. ACS Appl Mater Interfaces 7:4081–4088

    Article  CAS  Google Scholar 

  12. Boltasseva A (2009) Plasmonic components fabrication via nanoimprint. J Opt A Pure Appl Opt 11:114001

    Article  Google Scholar 

  13. Pimpin A, Srituravanich W (2011) Review on micro-and nanolithography techniques and their applications. Eng J 16:37–56

    Article  Google Scholar 

  14. Zhang D, Lu Y, Jiang J et al (2015) Nanoplasmonic biosensor: coupling electrochemistry to localized surface plasmon resonance spectroscopy on nanocup arrays. Biosens Bioelectron 67:237–242

    Article  CAS  Google Scholar 

  15. Zhang D, Lu Y, Zhang Q et al (2015) Nanoplasmonic monitoring of odorants binding to olfactory proteins from honeybee as biosensor for chemical detection. Sensor Actuat B Chem 221:341–349

    Article  CAS  Google Scholar 

  16. Zhang D, Zhang Q, Lu Y, et al. (2016) Peptide functionalized nanoplasmonic sensor for explosive detection. Nano-Micro Lett 8:36–43

    Google Scholar 

  17. Gartia MR, Hsiao A, Pokhriyal A et al (2013) Colorimetric plasmon resonance imaging using nano lycurgus cup arrays. Adv Opt Mater 1:68–76

    Article  Google Scholar 

  18. Stewart ME, Mack NH, Malyarchuk V et al (2006) Quantitative multispectral biosensing and 1D imaging using quasi-3D plasmonic crystals. Proc Natl Acad Sci U S A 103:17143–17148

    Article  CAS  Google Scholar 

  19. Kuznetsov AI, Evlyukhin AB, Goncalves MR et al (2011) Laser fabrication of large-scale nanoparticle arrays for sensing applications. ACS Nano 5:4843–4849

    Article  CAS  Google Scholar 

  20. Kee JS, Lim SY, Perera AP et al (2013) Plasmonic nanohole arrays for monitoring growth of bacteria and antibiotic susceptibility test. Sensor Actuat B Chem 182:576–583

    Article  CAS  Google Scholar 

  21. Lu Y, Li H, Zhuang S et al (2014) Olfactory biosensor using odorant-binding proteins from honeybee: Ligands of floral odors and pheromones detection by electrochemical impedance. Sensor Actuat B Chem 193:420–427

    Article  CAS  Google Scholar 

  22. Lu Y, Yao Y, Zhang Q et al (2015) Olfactory biosensor for insect semiochemicals analysis by impedance sensing of odorant-binding proteins on interdigitated electrodes. Biosens Bioelectron 67:662–669

    Article  CAS  Google Scholar 

  23. Li H-L, Zhang Y-L, Gao Q-K et al (2008) Molecular identification of cDNA, immunolocalization, and expression of a putative odorant-binding protein from an Asian honey bee, Apis cerana cerana. J Chem Ecol 34:1593–1601

    Article  CAS  Google Scholar 

  24. Jaworski JW, Raorane D, Huh JH et al (2008) Evolutionary screening of biomimetic coatings for selective detection of explosives. Langmuir 24:4938–4943

    Article  CAS  Google Scholar 

  25. Smith RG, D'Souza N, Nicklin S (2008) A review of biosensors and biologically-inspired systems for explosives detection. Analyst 133:571–584

    Article  CAS  Google Scholar 

  26. Ramoni R, Bellucci S, Grycznyski I et al (2007) The protein scaffold of the lipocalin odorant-binding protein is suitable for the design of new biosensors for the detection of explosive components. J Phys Condens Matter 19:395012

    Article  Google Scholar 

  27. Kuang Z, Kim SN, Crookes-Goodson WJ et al (2009) Biomimetic chemosensor: designing peptide recognition elements for surface functionalization of carbon nanotube field effect transistors. ACS Nano 4:452–458

    Article  Google Scholar 

  28. Zhang D, Zhang Q, Lu Y et al (2015) Electrophoresis-enhanced nanoplasmonic biosensor with nanocup arrays for protease detection in point-of-care diagnostics. China Nanomed 2015:202

    Google Scholar 

Download references

Acknowledgments

This work was supported by the National Natural Science Foundation of China (Grant No. 81371643), the Zhejiang Provincial Natural Science Foundation of China (Grant No. LR13H180002).

Author information

Authors and Affiliations

  1. Biosensor National Special Laboratory, Key Laboratory for Biomedical Engineering of Education Ministry, Department of Biomedical Engineering, Zhejiang University, Hangzhou, 310027, China

    Diming Zhang, Qian Zhang, Yanli Lu, Yao Yao, Shuang Li & Qingjun Liu

Authors
  1. Diming Zhang
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Qian Zhang
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Yanli Lu
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Yao Yao
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Shuang Li
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Qingjun Liu
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Qingjun Liu .

Editor information

Editors and Affiliations

  1. National Cancer Institute, National Institutes of Health, Rockville, Maryland, USA

    Avraham Rasooly

  2. National Cancer Institute, National Institutes of Health, Rockville, Maryland, USA

    Ben Prickril

Rights and permissions

Reprints and permissions

Copyright information

© 2017 Springer Science+Business Media LLC

About this protocol

Cite this protocol

Zhang, D., Zhang, Q., Lu, Y., Yao, Y., Li, S., Liu, Q. (2017). Nanoplasmonic Biosensor Using Localized Surface Plasmon Resonance Spectroscopy for Biochemical Detection. In: Rasooly, A., Prickril, B. (eds) Biosensors and Biodetection. Methods in Molecular Biology, vol 1571. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-6848-0_6

Download citation

  • DOI: https://doi.org/10.1007/978-1-4939-6848-0_6

  • Published:

  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-6846-6

  • Online ISBN: 978-1-4939-6848-0

  • eBook Packages: Springer Protocols

Publish with us

Policies and ethics

Search

Navigation